Assessment of Response to Treatment

  • R. E. Coleman


There are many treatments available for bone metastases and radiotherapy, endocrine manipulation and chemotherapy may all produce significant clinical improvement. Control of the tumour by systemic therapy reduces osteoclast activity allowing bone healing, mediated by osteoblasts, to occur. However, as assessment of response for most tumours is based on changes seen on serial plain radiographs, the precise effect of therapy is difficult to measure objectively. In 1977, on behalf of the Union Internationale Contre le Cancer (UICC), Hayward et al. defined criteria for objective assessment of response in advanced breast cancer (Table 6.1). These criteria have since been applied to assessment of response in other tumour types and although they are internationally accepted and have standardised the reporting of clinical trials, response in bone remains an imprecise entity.


Bone Metastasis Advanced Breast Cancer Calcium Excretion Urinary Calcium Excretion Prostatic Acid Phosphatase 
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© Springer-Verlag London Limited 1991

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  • R. E. Coleman

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