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Normal Bone Remodelling and Its Disruption in Metastatic Bone Disease

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Bone Metastases

Abstract

Bone is a metabolically active tissue which is continually being remodelled by a process involving the removal of microscopic packets of calcified matrix and their subsequent replacement at the same site by new bone. This normal physiological process can be disturbed by the direct local and/or the distant systemic effects of tumour cell products released by neoplastic cells. Recent research has indicated that many of the factors that may be involved in the regulation of bone remodelling and are produced by normal cells in the bone micro-environment can also be produced in excessive amounts by neoplastic cells. Thus metastatic malignant cells could directly interfere with the function of normal bone cells and so disrupt the bone micro-architecture.

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Authors
  1. B. F. Boyce
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Editors and Affiliations

  1. Imperial Cancer Research Fund Clinical Oncology Unit, United Medical and Dental Schools of Guy’s and St Thomas’s Hospitals, Guy’s Hospital, London, SE1 9RT, UK

    R. D. Rubens BSc, MD, FRCP (Professor) (Professor)

  2. Department of Nuclear Medicine, Guy’s Hospital, London, SE1 9RT, UK

    I. Fogelman BSc, MD, FRCP (Consultant Physician) (Consultant Physician)

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© 1991 Springer-Verlag London Limited

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Boyce, B.F. (1991). Normal Bone Remodelling and Its Disruption in Metastatic Bone Disease. In: Rubens, R.D., Fogelman, I. (eds) Bone Metastases. Springer, London. https://doi.org/10.1007/978-1-4471-3254-7_2

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  • DOI: https://doi.org/10.1007/978-1-4471-3254-7_2

  • Publisher Name: Springer, London

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  • Online ISBN: 978-1-4471-3254-7

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