Normal Bone Remodelling and Its Disruption in Metastatic Bone Disease

  • B. F. Boyce


Bone is a metabolically active tissue which is continually being remodelled by a process involving the removal of microscopic packets of calcified matrix and their subsequent replacement at the same site by new bone. This normal physiological process can be disturbed by the direct local and/or the distant systemic effects of tumour cell products released by neoplastic cells. Recent research has indicated that many of the factors that may be involved in the regulation of bone remodelling and are produced by normal cells in the bone micro-environment can also be produced in excessive amounts by neoplastic cells. Thus metastatic malignant cells could directly interfere with the function of normal bone cells and so disrupt the bone micro-architecture.


Bone Resorption Bone Remodelling Metastatic Bone Disease Stimulate Bone Resorption Normal Bone Remodelling 
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© Springer-Verlag London Limited 1991

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  • B. F. Boyce

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