The Nature of Metastatic Bone Disease

  • R. D. Rubens


Metastases in bone are common, yet malignant tumours rarely arise in the skeleton. Primary cancers in other tissues, notably the breast and colon, are common but seldom do metastases become established in these structures. The lungs, however, frequently give rise to cancer and secondary tumour growth in them is often seen. This variability in the patterns of primary tumour growth in different tissues and their susceptibility to metastatic disease is as intriguing as it is poorly understood. Before addressing bone metastases specifically, some general aspects of tumour biology will be considered briefly.


Breast Cancer Bone Metastasis Pathological Fracture Spinal Cord Compression Plain Radiography 
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© Springer-Verlag London Limited 1991

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  • R. D. Rubens

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