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Total Lymphoid Irradiation in Multiple Sclerosis

  • Stuart D. Cook
  • Corinne Devereux
  • Raymond Troiano
  • Christine Rohowsky-Kochan
  • Amiram Sheffet
  • Annette Jotkowitz
  • George Zito
  • Peter C. Dowling
Part of the Clinical Medicine and the Nervous System book series (CLIN.MED.NERV.)

Abstract

Immunosuppressive drugs have been increasingly used in both uncontrolled and controlled studies in an attempt to modify the relentless deterioration in neurologic function which commonly occurs in patients with chronic/progressive multiple sclerosis (CPMS) (The Multiple Sclerosis Study Group 1990; Rudge et al. 1989; Hauser et al. 1983; British and Dutch Multiple Sclerosis Azathioprine Trial Group 1988; Ellison et al. 1988). Unfortunately, no unequivocal long-term clinical benefits have been documented with immunosuppressive drugs in carefully controlled trials of CPMS. Further, many immunosuppressive drugs must be given at frequent intervals or even daily to sustain remissions in autoimmune disorders, which obviously increases their potential for toxic side effects including infection and neoplasia.

Keywords

Multiple Sclerosis Lupus Nephritis Mixed Leukocyte Reaction Total Lymphoid Irradiation Refractory Rheumatoid Arthritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag London Limited 1992

Authors and Affiliations

  • Stuart D. Cook
  • Corinne Devereux
  • Raymond Troiano
  • Christine Rohowsky-Kochan
  • Amiram Sheffet
  • Annette Jotkowitz
  • George Zito
  • Peter C. Dowling

There are no affiliations available

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