Abstract
Experimental allergic neuritis (EAN), an experimental model of GBS, developed as a by-product of research into experimental allergic encephalomyelitis (EAE). In 1895 Louis Pasteur had prepared the first rabies vaccines from dried formalin-treated rabbit brain. The vaccine provided some protection from rabies but also occasionally caused encephalomyelitis. Rivers and Schwentker (1935) showed that repeated injections of rabbit brain into monkeys would produce encephalomyelitis and Freund in 1949 showed that the same result could be achieved with a single injection provided that the nervous tissue was emulsified with an adjuvant. Early experiments were directed towards identifying the antigen. The encephalitogenic component of nervous tissue was found to reside largely in the major myelin basic protein (see Leibowitz and Hughes 1983 for review). More recently it has been demonstrated that highly purified proteolipid protein will also induce EAE (Yoshimura et al. 1985; Endoh et al. 1986). There is no theoretical reason why other CNS myelin antigens should not be capable of inducing EAE. Myelin basic protein (MBP), molecular weight 18 500, is rich in basic aminoacids, and its amino acid sequence is highly conserved from one species to another (Hashim 1980). However, there is great species variation in the part of the protein which is responsible for inducing EAE.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abramsky O, London Y (1975) Purification and partial characterization of two basic proteins from human peripheral nerve. Biochim Biophys Acta 393:556–562
Abramsky O, Teitelbaum D, Arnon R (1977) Experimental allergic neuritis induced by a basic neuritogenic protein (P1L) of human peripheral nerve origin. Eur J Immunol 7:213–217
Acha-Orbea H, Mitchell DJ, Timmermann L, et al. (1988) Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54:263–273
Adam AM, Atkinson PF, Hall SM, Hughes RAC, Taylor WA (1989) Chronic experimental allergic neuritis in Lewis rat. Neuropathol Appl Neurobiol 15:249–264
Alit G (1975) The node of Ranvier in experimental allergic neuritis. An electron microscopic study. J Neurocytol 4:63–76
Antony JH, Pollard JD, McLeod JG (1981) Effects of plasmapheresis on the course of experimental allergic neuritis in rabbits. J Neurol Neurosurg Psychiatry 44:1124–1128
Appenzeller O, Arnason BGW, Adams RD (1965) Experimental autonomic neuropathy: an immunologically induced disorder of reflex vasomotor function. J Neurol Neurosurg Psychiatry 28:510–515
Arnason BGW, Chelmicka-Szorc E (1972) Passive transfer of experimental allergic neuritis in Lewis rats by direct injection of sensitised lymphocytes into the sciatic nerve. Acta Neuropathol 22:1–6
Arnason BGW, Winkler GF, Hadler NM (1969) Cell-mediated demyelination of peripheral nerve in tissue culture. Lab Invest 21:1–10
Asbury AK, Arnason BG, Adams RD (1969) The inflammatory lesion in idiopathic polyneuritis. Its role in pathogenesis. Medicine 48:173–215
Askenase PW, Bursztajn S, Gershon NID, Gershon RK (1980) T cell dependent mast cell de-granulation and release of serotonin in immune delayed-type hypersensitivity. J Exp Med 152: 1358–1374
Astrom KE, Waksman BH (1962) The passive transfer of experimental allergic encephalomyelitis and neuritis with living lymphoid cells. J Pathol Bacteriol 83:89–100
Ballin RHM, Thomas PK (1968) Electron microscopic observations on demyelination and remyelination in experimental allergic neuritis. Part 1 (Demyelination). J Neurol Sci 8:1–18
Behan PO, Lamarche JB, Behan WB, Feldman RG (1969) Immunopathological mechanisms of allergic neuritis in animals, primates and man. Trans Am Neurol Assoc 94:219–222
Brosnan CF, Lyman WD, Tansey FA, Carter TH (1985) Quantitation of mast cells in experimental allergic neuritis. J Neuropathol Exp Neurol 44:196–203
Brosnan JV, Craggs RI, King RHM, Thomas PK (1984) Attempts to transfer experimental allergic neuritis with lymphocytes. J. Neuroimmunol 6:373–385
Brosnan JV, Fellowes R, Craggs RI, King RHM, Bowley TJ, Thomas PK (1985) Changes in lymphocyte subsets during the course of experimental allergic neuritis. Brain 108:315–334
Brosnan JV, Craggs RI, King RHM, Thomas PK (1987) Reduced susceptibility of T cell deficient rats to induction of experimental allergic neuritis. J Neuroimmunol 14:267–282
Brosnan JV, King RHM, Thomas PK, Craggs RI (1988) Disease patterns in EAN in the Lewis rat. J Neurol Sci 88:261–276
Brosnan SF, Tansey FA (1984) Delayed onset of experimental allergic neuritis in rats treated with reserpine. J. Neuropathol Exp Neurol 43:84–93
Brostoff S, Burnett S, Lampert P, Eylar E (1972) Isolation and characterisation of a protein from sciatic nerve myelin responsible for experimental allergic neuritis. Nature New Biol 235:210–212
Brostoff SW, Levit S, Powers JM (1977) Induction of experimental allergic neuritis with a peptide from myelin P2 basic protein. Nature 268:752–753
Brostoff SW, Powers JM, Weise MJ (1980) Allergic encephalomyelitis induced in guinea pigs by a peptide from the NH2 terminus of bovine P2 protein. Nature 285:103–104
Caspary EA, Field FJ (1965) Antibody response to central and peripheral nerve antigens in rat and guinea pig. J Neurol Neurosurg Psychiatry 28:179–182
Cohen IR, Weiner HL (1988) T cell vaccination. Immunol Today 9:332–334
Cragg BG, Thomas PK (1964) Changes in nerve conduction in experimental allergic neuritis. J Neurol Neurosurg Psychiatry 27:106–115
Craggs R, Brosnan JV, King RHM, Thomas PK (1986) Chronic relapsing experimental allergic neuritis in Lewis rats: effects of thymectomy and splenectomy. Acta Neuropathol 70:22–29
Cunningham JM, Powers JM, Brostoff SW (1983) Prevention of experimental allergic neuritis in the Lewis rat with bovine P2 protein. Brain Res 258:285–289
Curtis BM, Forno LS, Smith PE (1979) Reactivation of neuritogenic activity of P2 protein from peripheral nervous system myelin. Brain Res 175:387–391
De Lisi G, Berzofsky JA (1985) T cell antigenic sites tend to be amphipathic structures. Proc Natl Acad Sci USA 82:7048–7052
Ellerman KE, Powers JM, Brostoff SW (1988) A suppressor T-lymphocyte cell line for autoimmune encephalomyelitis. Nature 331:256–267
Endoh M, Tabira T, Kunishita T, Sakai K, Yamamura T, Taketomi T (1986) DM-20, a proteolipid apoprotein, is an encephalitogen of acute and relapsing autoimmune encephalomyelitis in mice. J Immunol 137:3832–3835
Feasby TE, Gilbert JJ, Hahn AF, Neilson M (1987) Complement depletion suppresses Lewis rat experimental allergic neuritis. Brain Res 419:97–103
Gilbert JJ, Feasby TE, Hahn AF (1983) Intraneural injection of lymphocytes in experimental allergic neuritis. Acta Neuropathol 61:61–64
Gross MLP, Craggs RI, King RHM, Thomas PK (1983) The treatment of experimental allergic neuritis by plasma exchange. J Neurol Sci 61:149–160
Hahn AF, Feasby TE, Gilbert JJ (1985) Blood—nerve barrier studies in experimental allergic neuritis. Acta Neuropathol 68:101–109
Happ MP, Kiraly AS, Offner H, Vandenbark A, Heber-Katz E (1988) The autoreactive T cell population in experimental allergic encephalomyelitis: T cell receptor B-chain rearrangements. J Neuroimmunol 19:191–204
Hartung HP, Schafer B, Heininger K, Stoll G, Toyka KV (1988) The role of macrophages and line-mediated experimental autoimmune neuritis in the rat. Neurosci Lett 83:195–200
Hartung H-P, Schafer B, Heininger K, Stoll G, Toyka KV (1988) The role of macrophages and eicosanoids in the pathogenesis of experimental allergic neuritis. Brain 111:1039–1059
Harvey GK, Pollard JD, Schindhelm K, Antony J (1987) Chronic experimental allergic neuritis. An electrophysiological and histological study in the rabbit. J Neurol Sci 81:215–226
Hashim GA (1980) T cell activation and suppression. In: Davison AN, Cuzner ML (eds) Experimental allergic encephalomyelitis and multiple sclerosis. Academic Press, New York, pp 79–104
Heber-Katz E, Acha-Orbea H (1989) The V-region hypothesis: evidence from autoimmune encephalomyelitis. Immunol Today 10:164–169
Heininger K, Stoll G, Linington C, Toyka KV, Wekerle H (1986) Conduction failure and nerve conduction slowing in experimental allergic neuritis induced by P2-specific T cell lines. Ann Neurol 19:44–49
Heininger K, Schafer B, Hartung HP, Fierz W, Linington C, Toyka KV (1988) The role of macrophages in experimental allergic neuritis induced by a P2 specific T cell line. Ann Neurol 23: 326–331
Heitman NR, Mannweiler KL (1956) Experimental animal studies on allergic polyneuroses. Dtsch Z Nervenheilk 177:28–47
Hoffman PM, Powers JM, Weise MJ, Brostoff SW (1980) Experimental allergic neuritis I. Rat strain differences in the response to bovine myelin antigens. Brain Res 195:355–362
Hsieh DL, Weise MJ, Levit S, Powers JM, Brostoff SW (1981) Structure of bovine P2 basic protein: sequence of a carboxyterminal segment that is a neuritogen in rabbits. J Neurochem 36:913–916
Hughes RAC (1974) Protection of rats from experimental allergic encephalomyelitis with antiserum to guinea pig spinal cord. Immunology 26:703–711
Hughes RAC, Kadlubowski M (1980) Experimental allergic neuritis in the rat. In: Rose FC, Behan, PO (eds) Animal models of neurological disease. Pitman Medical, Tunbridge Wells, pp 95–103
Hughes RAC, Powell HC (1984) Experimental allergic neuritis: demyelination induced by P2 alone and non-specific enhancement by cerebroside. J Neuropathol Exp Neurol 43:154–161
Hughes RAC, Kadlubowski M, Gray IA, Leibowitz S (1981a) Immune responses in experimental allergic neuritis. J Neurol Neurosurg Psychiatry 44:565–569
Hughes RAC, Kadlubowski M, Hufschmidt A (1981b) Treatment of acute inflammatory polyneuropathy. Ann Neurol 9 Supp1:125–133
Hughes RAC, Powell HC, Braheny SL, Brostoff SW (1985) Endoneurial injection of antisera to myelin antigens. Muscle Nerve 8:516–522
Hughes RAC, Atkinson PF, Gray IA, Taylor WA (1987) Major histocompatibility antigens and lymphocyte subsets during experimental allergic neuritis in the Lewis rat. J Neurol 234:390–395
Ichijo K, Fujimoto Y, Okada K (1981) Ultrastructural study of experimental allergic neuritis in the chicken. I. Cell migration, granuloma formation and demyelination. Zentralbl Veterinarmed [B] 28:210–225
Ishaque A, Szymanska I, Ramwani J, Eylar EH (1981) Allergic neuritis: phospholipid requirement for the disease inducing conformation of the P2 protein. Biochim Biophys Acta 669:28–32
Ishaque A, Hofmann T, Eylar EH (1982) The complete amino acid sequence of the rabbit P2 protein. JAMA 257:592–595
Izumo S, Linington C, Wekerle H, Meyermann R (1985) Morphological study on EAN mediated by T cell line specific for bovine P2 protein in Lewis rats. Lab Invest 53:209–218
Kadlubowski M, Hughes RAC (1979) Identification of the neuritogen responsible for experimental allergic neuritis. Nature 277:140–141
Kadlubowski M, Hughes RAC (1980) The neuritogenicity and encephalitogenicity of P2 in the rat, guinea pig and rabbit. J Neurol Sci 48:171–178
Kadlubowski M, Hughes RAC, Gregson NA (1980) Experimental allergic neuritis in the Lewis rat: characterisation of the activity of peripheral myelin and its major basic protein P2. Brain Res 184: 439–454
King RHM, Thomas PK, Pollard JD (1977) Axonal and dorsal root ganglion cell changes in experimental allergic neuritis. Neuropathol Appl Neurobiol 3:471–486
King RHM, Craggs RI, Gross MLP, Tompkins C, Thomas PK (1983) Suppression of experimental allergic neuritis by cyclosporin A. Acta Neuropathol 59:262–268
King RHM, Craggs RI, Gross MLP, Thomas PK (1985) Effects of glucocorticoids on experimental allergic neuritis. Exp Neurol 87:9–19
Kitamura K, Suzuki M, Suzuki A, Uyemura K (1980) The complete amino acid sequence of the P2 protein in bovine peripheral nerve myelin. FEBS Lett 115:27–30
Konovalov G, Korneva E, Khai L (1971) Effect of destruction of the posterior hypothalamic area on experimental allergic neuritis. Brain Res 29:383–386
Lampert PW (1967) Electron microscopic studies on ordinary and hyperacute experimental allergic encephalomyelitis. Acta Neuropathol 9:99–126
Lampert PW (1969) Mechanism of demyelination in experimental allergic neuritis. Electron microscopic studies. Lab Invest 20:127–138
Lassmann H (1983) Comparative neuropathology of chronic experimental allergic encephalomyelitis and multiple sclerosis. Springer-Verlag, Berlin
Lassmann H, Brunner C, Bradl M, Linington (1988) Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determines the size and structure of demyelinated lesions. Acta Neuropathol 75:566–576
Lehrich JR, Arnason BG (1971) Suppression of experimental allergic neuritis in rats by prior immunization with nerve in saline. Acta Neuropathol 18:144–155
Leibowitz S, Hughes RAC (1983) Immunology of the nervous system. Edward Arnold, London, pp 1–304
Levine S, Wenk EJ (1963) Allergic neuritis induced in rats without the use of mycobacteria. Proc Soc Exp Biol Med 113:898–900
Linington C, Izumo S, Suzuki M, Uyemura M, Meyermann R, Wekerle H (1984) A permanent rat T cell line that mediates experimental allergic neuritis in the rat in vitro. J Immunol 133: 1946–1950
Linington C, Mann A, Izumo S et al. (1986) Induction of experimental allergic neuritis in the BN rat: P2 protein-specific T cells overcome resistance to actively induced disease. J Immunol 137: 3826–3831
Linington C, Bradl M, Lassmann H, Brunner C, Vass K (1988) Augmentation of demyelination in rats: acute allergic encephalomyelitis directed against a myelin/oligodendrocyte glycoprotein. Am J Pathol 130:443–454
London Y (1971) Ox peripheral nerve myelin membrane. Purification and partial characterization of two basic proteins. Biochim Biophys Acta 249:188–196
Madrid RE (1983) Chronic progressive and relapsing EAN in guinea pigs. In: Battistin L, Hashim GA, Lajtha A (eds) Clinical and biological aspects of peripheral nerve diseases. Alan R. Liss, New York, pp 265–276
Madrid RE, Wisniewski HM (1977) Axonal degeneration in demyelinating disorders. J Neurocytol 6:103–117
McDermott JR, Keith AB (1979) Suppression of experimental allergic neuritis with P2 protein of peripheral nervous system myelin. Z Naturforsch [C] 34:641–643
McDermott JR, Wisniewski HM (1977) Studies on the myelin protein changes and antigenic properties of rabbit sciatic nerves undergoing Wallerian degeneration. J Neurol Sci 33:81–94
Milek DJ, Cunningham JM, Powers JM, Brostoff SW (1983) Experimental allergic neuritis: Humoral and cellular responses to the cyanogen bromide peptides of the P2 protein. J Neuroimmunol 4:105–116
Milner P, Lovelidge GA, Taylor WA, Hughes RAC (1987) Po myelin protein produces experimental allergic neuritis in Lewis rats. J Neurol Sci 79:275–285
Morey MK, Hughes RAC, Powell HC (1985) Are Schwann cells involved in experimental allergic neuritis? Acta Neuropathol 67:75–80
Nagai Y, Uchida T, Takeda S, Ikuta F (1978) Restoration of activity for induction of experimental allergic peripheral neuritis by a combination of myelin basic protein P2 and gangliosides from peripheral nerve. Neurosci Lett 8:247–254
Nomura K, Hamaguchi K, Ohno R et al. (1987) Cell-mediated immunity to bovine P2 protein and neuritogenic synthetic peptide in experimental allergic neuritis. J Neuroimmunol 15:25–35
Ohno R, Hamaguchi K, Nomura K et al. (1988) Immune responses in experimental allergic neuritis treated with corticosteroids. Acta Neurol Scand 77:468–473
Olee T, Powers JM, Brostoff SW (1988) A T cell epitope for experimental allergic neuritis. J Neuroimmunol 19:167–173
Olee T, Weise M, Powers J, Brostoff SW (1989) A T cell epitope for experimental allergic neuritis is an amphipathic a-helical structure. J Neuroimmunol 21:235–240
Olsson T, Holdmahl R, Klareskog L, Forsum U, Kristinsson K (1984) Dynamics of Ia expressing cells and T lymphocytes of different subsets during experimental allergic neuritis in Lewis rats. J Neurol Sci 66:141–149
Ota K, Irie H, Takahashi K (1987) T cell subsets and Ia-positive cells in the sciatic nerve during the course of experimental allergic neuritis. J Neuroimmunol 13:283–292
Paraf A (1963) Polyradiculonévrite experimentale chez le mouton, ses rapports avec la syndrome de Guillain—Barré chez l’homme. Ann Inst Pasteur 104:208–218
Paterson PY, Harwin SM (1963) Suppression of allergic encephalomyelitis in rats by means of anti-brain serum. J Exp Med 117:755–762
Paty DW (1971) An encephalitogenic basic protein from human peripheral nerve. Eur Neurol 5: 281–287
Pender MP, Sears TA (1984) The pathophysiology of acute experimental allergic encephalomyelitis in the rabbit. Brain 107:699–726
Peter M, Quaglio GL (1967) Experimental allergic neuritis in the chicken. Pathol Vet 4:464–476 Pollard JD, King RHM, Thomas PK (1975) Recurrent experimental allergic neuritis: an electron microscope study. J Neurol Sci 24:365–383
Powell HC, Braheny SL, Myers RR, Rodriguez M, Lampert PW (1983) Early changes in experimental allergic neuritis. Lab Invest 83:332–338
Raine CS, Bornstein MB (1979) Experimental allergic neuritis — ultrastructure of serum induced myelin aberrations in peripheral nervous system cultures. Lab Invest 40:423–432
Raine CS, Johnson AB, Marcus DM, Suzuki A, Bornstein MB (1981) Demyelination in vitro — absorption studies demonstrate that galactocerebroside is a major target. J Neurol Sci 52:117–131
Rivers TM, Schwentker FF (1935) Encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys. J Exp Med 61:689–703
Robinson HC, Alit G, Evans DHL (1972) A study of the capacity of myelinated and unmyelinated nerves to induce experimental allergic neuritis. Acta Neuropathol 21:99–108
Rostami A, Brown MJ, Lisak RP, Sumner AJ, Zweiman B, Pleasure DE (1984) The role of myelin P2 protein in the production of experimental allergic neuritis. Ann Neurol 16:680–685
Rostami A, Burns JB, Brown MJ et al. (1985) Transfer of experimental allergic neuritis with P2-reactive T cell lines. Cell Immunol 91:354–361
Rostami A, Rosen JL, Hickey WF, Brown MJ (1986a) Experimental allergic neuritis can occur in experimental allergic encephalomyelitis-resistant Lewis rats. Neurology 36:312
Rostami A, Rosen JL, Cancro MP, Brown MJ, Pleasure DE (1986b) The variable susceptibility of inbred mice to experimental allergic neuritis. Neurology 36:304–305
Rostami AM, Ventura E, Kimura H, Brown MJ, Pleasure DE (1988) Induction of severe experimental allergic neuritis with a synthetic peptide corresponding to the 53–78 amino acid sequence of the myelin P2 protein. Neurology 38:375
Saida K, Saida T, Brown MJ (1979) In vitro demyelination induced by intraneural injection of antigalactocerebroside serum: a morphological study. Am J Pathol 95:99–116
Saida T, Saida K, Silberberg DH, Brown MJ (1978) Transfer of demyelination by injection of experimental allergic neuritis serum. Nature 272:639–641
Saida T, Saida K, Dorfman SH (1979a) Experimental allergic neuritis induced by sensitisation with galactocerebroside. Science 204:1103–1106
Saida T, Saida K, Silberberg DH (1979b) Demyelination produced by experimental allergic neuritis serum and anti-galactocerebroside antiserum in CNS cultures. An ultrastructural study. Acta Neuropathol 48:18–25
Saida T, Saida K, Silberberg DH, Brown MK (1981) Experimental allergic neuritis induced by galactocerebroside. Ann Neurol 9 supp1:87–101
Seil FJ, Kies MW, Bacon ML (1981) A comparison of demyelinating and myelination inhibiting factor induction by whole peripheral nerve tissue and P2 protein. Brain Res 210:441–448
Sheremata WA, Behan PO (1973) Experimental allergic neuritis: a new experimental approach. J Neurol Neurosurg Psychiatry 36:139–145
Smith ME, Forno LS, Hoffman WW (1979) Experimental allergic neuritis in the Lewis rat. J Neuropathol Exp Neurol 38:377–391
Steinman L, Smith ME, Forno LS (1981) Genetic control of susceptibility to experimental allergic neuritis and the immune response to P2 protein. Neurology 31:950–954
Stoll G, Schwendemann G, Heininger K et al. (1986) Relation of clinical, serological, morphological and electrophysiological findings in galactocerebroside induced experimental allergic neuritis. J Neurol Neurosurg Psychiatry 49:258–264
Strigard K, Olsson T, Larsson P, Holmdahl R, Klareskog L (1988) Modulation of experimental allergic neuritis in rats by in vivo treatment with monoclonal anti T cell antibodies. J Neurol Sci 83:283–291
Strigard K, Larsson P, Holmdahl R, Klareskog L, Olsson T (1989) In vivo monoclonal antibody treatment with Ox19 (anti-rat CD5) causes disease relapse and terminates P2-induced immunospecific tolerance on experimental allergic neuritis. J Neuroimmunol 23:11–18
Sumner AJ, Saida K, Saida T, Silberberg DH, Asbury AK (1982) Acute conduction block associated with experimental antiserum mediated demyelination of peripheral nerve. Ann Neurol 11:469–477
Suzuki M, Kitamura K, Uyemura K, Ogawa Y, Ishihara Y, Matsuyama H (1980) Neuritogenic activity of peripheral nerve proteins in Lewis rats. Neurosci Lett 19:353–358
Suzuki M, Kitamura K, Sakamoto T, Uyemura K (1982) The complete amino acid sequence of human P2 protein. J Neurochem 39:1759–1762
Suzuki M, Kitamura K, Uyemura K, Ogawa Y, Nozaki S, Marumatsu I (1984) Synthesis and neuritogenic activity of the peptides related to P2 protein. In: Alvord EC, Kies MW, Suckling AJ (ed) Experimental allergic encephalomyelitis — a useful model for multiple sclerosis. Alan R Liss, New York, pp 478–492
Szymanska I, Ishaque A, Ramwani JAI, Eylar EH (1981) Allergic neuritis: a neuritogenic peptide from the P2 protein that induces disease in rats. J Immunol 126:1203–1206
Tansey FA, Brosnan CF (1982) Protection against experimental allergic neuritis with silica quartz dust. J Neuroimmunol 3:169–179
Taylor WA, Hughes RAC (1985) Experimental allergic neuritis induced in SJL mice by bovine P2. J Neuroimmunol 8:153–157
Taylor WA, Hughes RAC (1988) Responsiveness to P2 of blood and cauda equina derived lymphocytes in experimental allergic neuritis: preliminary characterisation of a cauda equina derived P2 specific T cell line. J Neuroimmunol 19:279–289
Taylor WA, Hughes RAC, Lee T (1988) Lack of effect of fish oil enriched diet on experimental allergic neuritis in Lewis rats. J Neuroimmunol 17193–197
Tuck RR, Pollard JD, McLeod JG (1981) Autonomic neuropathy: experimental allergic neuritis: an electrophysiological and histological study. Brain 104:187–208
Tuck RR, Antony JH, McLeod JG (1982) F-wave in experimental allergic neuritis. J Neurol Sci 56:173–184
Uyemura K, Suzuki M, Kitamura K et al. (1982) Neuritogenic determinant of bovine P2 protein in peripheral nerve myelin. J Neurochem 39:895–898
Waksman BH, Adams RD (1955) Allergic neuritis: experimental disease of rabbits induced by the injection of peripheral nervous tissue and adjuvants. J Exp Med 102:213–225
Waksman BH, Adams RD (1956) A comparative study of experimental allergic neuritis in the rabbit, guinea pig and mouse. J Neuropathol Exp Neurol 15:293–310
Watts PM, Taylor WA, Hughes RAC (1989) High-dose methylprednisolone suppresses experimental allergic neuritis in the Lewis rat. Exp Neurol 103:101–104
Weise MJ, Hsieh D, Hoffman PM, Powers JM, Brostoff SW (1980) Bovine peripheral nervous system myelin P2 protein: chemical and immunological characterization of the cyanogen bromide peptides. J Neurochem 35:393–400
Whitaker JN, Seyer JM (1984) Degradation of bovine P2 protein by bovine brain cathepsin D. Neurochem Res 9:1431–1443
Wisniewski H, Prineas J, Raine CS (1969) An ultrastructural study of experimental demyelination and remyelination. 1 Acute experimental allergic encephalomyelitis in the peripheral nervous system. Lab Invest 21:105–118
Wisniewski HM, Brostoff SW, Carter H, Eylar EH (1974) Recurrent experimental allergic polyganglioradiculoneuritis. Arch Neurol 30:347–358
Yonezawa T, Ishihara Y, Matsuyama H (1968) Studies on experimental allergic neuritis. I. Demyelinating patterns studied in vitro. J Neuropathol Exp Neurol 27:453–463
Yoshimura T, Kunishita T, Sakai K, Endoh M, Namikawa T, Tabira T (1985) Chronic experimental allergic encephalomyelitis in guinea pigs induced by proteolipid protein. J Neurol Sci 69:47–58
Zamvil SS, Mitchell DJ, Moore AC, Kitamura K, Steinman L, Rothbard JB (1986) T cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature 324:258–260
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag London Limited
About this chapter
Cite this chapter
Hughes, R.A.C. (1990). Experimental Allergic Neuritis. In: Guillain-Barré Syndrome. Clinical Medicine and the Nervous System. Springer, London. https://doi.org/10.1007/978-1-4471-3175-5_3
Download citation
DOI: https://doi.org/10.1007/978-1-4471-3175-5_3
Publisher Name: Springer, London
Print ISBN: 978-1-4471-3177-9
Online ISBN: 978-1-4471-3175-5
eBook Packages: Springer Book Archive