Effects of human seminal plasma on the lymphocyte response to viral infection

  • W. P. Soutter
  • M. J. Turner
  • J. O. White


Human seminal plasma suppresses various components of the immune system in vitro and in vivo. The proliferative response of both T and B lymphocytes to mitogen or antigen;(1.2) recognition of target antigens by macrophages and polymorphonuclear leucocytes;(1.3) recognition and destruction of tumour or viral infected cells by natural killer cells (NK) and cytotoxic T cells;(2.4) and phagocytosis by macrophages(3) can all be inhibited by seminal plasma in vitro. Mouse prostatic fluid inhibits complement-mediated haemolysis.(5) Most of these effects can be achieved with very low concentrations of seminal plasma (0.05-0.1% by volume) and can be demonstrated with seminal plasma from several mammalian species.(6)


Human Immunodeficiency Virus Seminal Plasma Lymphocyte Response Human Seminal Plasma Heterosexual Anal Intercourse 
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© The Royal College of Obstetricians and Gynaecologists 1988

Authors and Affiliations

  • W. P. Soutter
  • M. J. Turner
  • J. O. White

There are no affiliations available

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