Acute Myocardial Infarction

Part of the Treatment in Clinical Medicine book series (TC MEDICINE)


Acute myocardial infarction develops when myocardial ischaemia occurs for a sufficient time to cause necrosis of a localised area of myocardium. The initial reduction in myocardial blood flow may be secondary to:
  1. 1.

    Coronary artery spasm or increased vasoconstrictor tone in normal or severely stenosed coronary arteries (Maseri et al. 1978)

  2. 2.

    Platelet aggregation in the presence of severe atheroma, leading to reduced flow

  3. 3.

    Subintimal haemorrhage with bleeding into an atheromatous plaque

  4. 4.

    Intracoronary thrombosis (Davies et al. 1976)

Infarction may occur without totoal coronary artery occlusion when coronary flow falls due to severe hypotension. This can be associaed with haemorrhage, trauma, severe dehydration or shock accompanying any other condition.


Acute Myocardial Infarction Infarct Size Myocardial Blood Flow Cardiogenic Shock Coronary Artery Occlusion 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  1. 1.Royal InfirmaryGlasgowScotland, UK
  2. 2.Stobhill General HospitalGlasgowScotland, UK

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