Pharmacokinetic Properties of Cardiovascular Drugs
- 292 Downloads
In the last three decades there has been a great increase in the number of drugs available to treat cardiovascular diseases. Patients have a wide spectrum of clinical presentation and can provide complex management problems. They may require emergency treatment using drugs by a parenteral route or long-term oral therapy during which time many clinical parameters are changing. The therapeutic and toxic effects of drugs depend on the available concentration at the site of action, and in general the drug concentration in plasma or whole blood correlates well with the pharmacological response. The development of sensitive and specific analytical methods to measure drugs in blood and/or urine has greatly enhanced our knowledge of their pharmacokinetic behaviour (Mayer et al. 1980).
KeywordsTherapeutic Drug Monitoring Cardiac Glycoside Cardiovascular Drug Intermittent Infusion Intrinsic Clearance
Unable to display preview. Download preview PDF.
- Beeley LN (1984) Drug interactions. British National FormularyGoogle Scholar
- Fenster PE, Perrier D (1982) Applications of pharmacokinetic principles to cardiovascular drugs. Med Cones Cardiovasc Dis 57: 91–96Google Scholar
- Mayer SE, Melman KL, Gilman KG (1980) General principles. In: Gilman AG, Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics. Macmillan, New York, pp 1–27Google Scholar
- Wilkinson GR, Shand DG (1975) A physiologic approach to hepatic drug clearance. Clin Pharmacol Ther 18: 337–390Google Scholar