Corticosteroids have been used and abused in many conditions since their dramatic debut in 1948. This brief chapter will emphasise their toxicity, which may be considerable with prolonged use, while attempting to highlight indications for their prescription. Much of the relevant literature on the subject is more than 10 years old, and despite 30 years of use corticosteroids still exemplify the confusion and controversy which surround drug therapy in rheumatology.
KeywordsToxicity Aspirin Pancreatitis Osteoarthritis Dexamethasone
Unable to display preview. Download preview PDF.
- Bacon PA, Myles AB, Berntwell CG, Daly JR, Savage O (1966) Corticosteroid withdrawal in rheumatoid arthritis. Lancet II: 935–937Google Scholar
- Castles J J (1979) Clinical pharmacology of glucocorticoids. In: Hollander JL, McCarty DJ Jr (eds) Arthritis and allied conditions, 9th edn. Lea and Febiger, PhiladelphiaGoogle Scholar
- Haynes RC, Murad F (1980) Adrenocorticotrophic hormone, adrenocortical steroids and their synthetic analogues. In: Goodman WS, Gillman AC (eds) The pharmacological basis of therapeutics, 6th edn. Macmillan, New York, pp 1466–1496Google Scholar