Surgery and Post-operative Thrombosis

  • P. N. Matthews


Venous thrombosis remains one of the commonest causes of mortality and morbidity following surgery. Since Virchow described his now classic triad over 100 years ago, many advances have been made in both diagnosis and prevention of venous thrombosis, and yet in some ways we are no nearer to a better understanding of the fundamental mechanism. While we recognise the fact that certain patients fall into “high risk” categories, we still do not really understand why one patient gets a thrombosis and another seemingly very similar patient does not.


Venous Thrombosis Inguinal Hernia Repair Blood Viscosity Plasma Fibrinogen Plasma Fibrinogen Level 
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  1. Aronson H B, Magora F, Schenker J G (1971). The effect of oral contraceptives on blood viscosity. Am J Obstet Gynecol 110: 997–1001PubMedGoogle Scholar
  2. Bailey M J, Johnston C L W, Yates C J P, Somerville P G, Dormandy J A (1979). Preoperative haemoglobin as predictor of outcome of diabetic amputations. Lancet ii: 168–170Google Scholar
  3. Baumgartner H R (1973). The role of blood flow in platelet adhesion, fibrin deposition and formation of mural thrombi. Microvasc Res 5: 167–179PubMedCrossRefGoogle Scholar
  4. Born G V R (1977). Fluid, mechanical and biochemical interactions in haemostasis. Br Med Bull 33: (3): 193–197PubMedGoogle Scholar
  5. Bouhoutsos J, Morris T, Chevatzas D, Martin P (1974). The influence of haemoglobin and platelet levels on the results of arterial surgery. Br J Surg 61: 984–986PubMedCrossRefGoogle Scholar
  6. Clark C, Cotton L T (1968). Blood flow in the deep veins of the leg. Br J Surg 55 (3): 211–214PubMedCrossRefGoogle Scholar
  7. Dormandy J A (1971). Influence of blood viscosity on blood flow and the effect of low molecular weight Dextran. Br Med J 4: 716–719PubMedCrossRefGoogle Scholar
  8. Dormandy J A, Edelman J B (1973). High blood viscosity: an aetiological factor in venous thrombosis. Br J Surg 60 (3): 187–190PubMedCrossRefGoogle Scholar
  9. Dormandy J A, Hoare E, Colley J, Arrowsmith D E, Dormandy T L (1973). Clinical, haemodynamic, rheological and biochemical findings in 126 patients with intermittent claudication. Br Med J 4: 576–581PubMedCrossRefGoogle Scholar
  10. Erdi A, Thomas D P, Kakkar V V, Lane D A, Dormandy J A (1976). Effect of low dose subcutaneous heparin on whole blood viscosity. Lancet ii: 342–344Google Scholar
  11. Gelin L, Jansen H (1975). Moderate preoperative haemodilution. Mortality and thrombus formation in general surgery. In: Messmer K, Schmid-Schönbein H (eds) Intentional haemodilution, Biblthca. Haemat. No. 41. Karger, Basel, pp 239–247Google Scholar
  12. Hales S (1733) Statistical Essays Vol. 2, Innys and Manby, LondonGoogle Scholar
  13. Hamer J D, Ashton F, Meynell M J (1973) Factors influencing prognosis in the surgery of peripheral vascular disease: platelet adhesiveness, plasma fibrinogen and fibrinolysis. Br J Surg 60 (5): 386–389Google Scholar
  14. Harvey-Kemble J V, Hickman J A (1972) Post-operative changes in blood viscosity and the influence of haematocrit and plasma fibrinogen. Br J Surg 59 (8): 629–632CrossRefGoogle Scholar
  15. Humphreys W V, Walker A, Charlesworth D (1976) Altered viscosity and yield stress in patients with abdominal malignancy: relationship to DVT. Br J Surg 63: 559–561PubMedCrossRefGoogle Scholar
  16. Hunter J (1794) A treatise on the blood, inflammation and gunshot wounds. John Richardson, Chapter I.Google Scholar
  17. Kakkar V V, Howe C T, Nicolaides A N, Renney J T G, Clarke M B (1970) Deep vein thrombosis of the leg. Is there a “high risk” group? Am J Surg 120: 527–530PubMedCrossRefGoogle Scholar
  18. Kline A, Hughes L E, Campbell H, Williams A, Zlosnick J, Leach K G (1975) Dextran 70 in the prophylaxis of thrombo-embolic disease after surgery: a clinically orientated, randomised, double blind trial. Br Med J 2: 109–112PubMedCrossRefGoogle Scholar
  19. Lowe G D O, Campbell A F, Meek D R, Forbes C D, Prentice C R M, Cummings S (1978) Subcutaneous ancrod in prevention of deep-vein thrombosis after fractured neck of femur. Lancet ii: 698–700Google Scholar
  20. McLachlin J, Paterson J C (1951) Some basic observations on venous thrombosis and pulmonary embolism. Surg Gynecol Obstet 93 (1): 1–8PubMedGoogle Scholar
  21. McLachlin A D, McLachlin J A, Jory T A, Rawling E G (1960) Venous stasis in the lower extremities. Ann Surg 152: 678–685PubMedCrossRefGoogle Scholar
  22. Messmer K, Sunder-Plassmann L, Klovekorn W P, Holper K (1972a) Circulatory significance of haemodilution. In: Harders H (ed) Advances in microcirculation. Karger, Basel, Vol. 4, 1–77Google Scholar
  23. Messmer K, Lewis D H, Sunder-Plassmann L, Klovekorn W P, Mendier N, Holper K (1972b) Acute normovolaemic haemodilution. Europ Surg Res 4.: 55–70Google Scholar
  24. Poiseuille J L (1846) C R Acad Sci Paris 9: 961–967, 1041–1048Google Scholar
  25. Postlethwaite J C (1976) The importance of plasma fibrinogen in vascular surgery. Ann Roy Coll Surg Eng 58: 457–464PubMedGoogle Scholar
  26. Postlethwaite J C, Goyle K B, Dormandy J A, Hynd J W (1977) Improvement in experimental vascular graft patency by controlled defibrination. Br J Surg 64: 28–30PubMedCrossRefGoogle Scholar
  27. Renwick S, Gabe I T, Shillingford J P, Martin P (1968) Blood flow after reconstructive arterial surgery measured by implanted electromagnetic flow probes. Surgery 64 (3): 544–553PubMedGoogle Scholar
  28. Scholz P M, Kinney J M, Chien S (1975) The effects of major abdominal operations on human blood rheology. Surgery 77 (3): 351–359PubMedGoogle Scholar
  29. Sevitt S (1974) The structure and growth of valve pocket emboli in femoral veins. J Clin Pathol 27: 517–528PubMedCrossRefGoogle Scholar
  30. Tietjen G W, Chien S, Scholz P, Gump F E, Kinney J M (1977) Changes in blood viscosity and plasma proteins in carcinoma. J Surg Oncol 9: 53–59PubMedCrossRefGoogle Scholar
  31. Vessey M P, Doll R (1969) Investigation of relation between the use of oral contraceptives and thrombo-embolic disease — a further report. Br Med J 2: 651–657PubMedCrossRefGoogle Scholar
  32. Virchow R (1846) Beitr Exp Pathol 2: 227–380Google Scholar
  33. Wasserman L R, Gilbert H S (1963) Surgery in polycythaemia vera. New Eng J Med 269 (23): 1226–1230PubMedCrossRefGoogle Scholar
  34. Weed R I (1970) The importance of erythrocyte deformability. Am J Med (Editorial) 49 (2): 146–150Google Scholar
  35. Yates C J P, Berent A, Andrews V, Dormandy J A (1979) Increase in leg blood flow by normovolaemic haemodilution in intermittent claudication. Lancet ii: 166–168Google Scholar

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© Spring-Verlag Berling Heidelberg 1981

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  • P. N. Matthews

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