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Haematocrit, Blood Viscosity, Cerebral Blood Flow, and Vascular Occlusion

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Abstract

Initially the evidence for a positive relationship between venous haematocrit (VH) and vascular occlusive events will be examined. In the next section the effect of haematocrit change on the rheological characteristics of blood will be presented. This will be followed by presenting evidence for the influence of blood viscosity on cerebral blood flow. Finally, the association between VH, blood viscosity, cerebral blood flow and vascular occlusive events will be discussed.

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References

  • Abu-Zeid H A H, Chapman, J M (1976) The relation between haemoglobin level and the risk for ischaemic heart disease: A prospective study. J Chron Dis 29: 395–403

    Article  PubMed  CAS  Google Scholar 

  • Bailey M J, Yates C J P, Johnston C L W, Somerville P G, Dormandy J A (1979) Preoperative haemoglobin as predictor of outcome of diabetic amputations. Lancet ii: 168–170

    Article  Google Scholar 

  • Barabas A P, Offen D N, Meinhard E A (1973) The arterial complications of polycythaemia vera. Br J Surg 60: 183–187

    Article  PubMed  CAS  Google Scholar 

  • Bouhoutsos J, Morris T, Chavatzas D, Martin P (1974) The influence of haemoglobin and platelet levels on the results of arterial surgery. Br J Surg 61: 984–986

    Article  PubMed  CAS  Google Scholar 

  • Brown S M, Gilbert H S, Krauss S, Wasserman L R (1971) Spurious (relative) polycythaemia. A nonexistent disease. Am J Med 50: 200–207

    Article  PubMed  CAS  Google Scholar 

  • Bugliarello G, Kapur C, Hsiao G (1965) The profile viscosity and other characteristics of blood flow in a non-uniform shear field. Proc. 4th int. Cong. Rheology. Interscience, New York, p 351

    Google Scholar 

  • Burch G E, De Pasquale N P (1963) Phlebotomy. Arch Intern Med 111: 687–695

    Article  CAS  Google Scholar 

  • Burge P S, Johnson W S, Prankerd T A J (1975) Morbidity and mortality in pseudopolycythaemia. Lancet is 1266–1269

    Google Scholar 

  • Chievitz E, Thiede T (1962) Complications and causes of death in polycythaemia. Acta Med Scand 172: 513–523

    Article  PubMed  CAS  Google Scholar 

  • Clark C, Cotton L T (1968) Blood flow in deep veins of leg. Recording technique and evaluation of methods to increase flow during operation. Br J Surg 55: 211–214

    Article  PubMed  CAS  Google Scholar 

  • Conley C L, Russell R P, Thomas C B, Tumulty P A (1964) Haematocrit values in coronary artery disease. Arch Intern Med 113: 170–176

    Article  PubMed  CAS  Google Scholar 

  • Davies S W, Glynne-Jones E, Lewis E P (1973) False polycythaemia. J Clin Pathol 26: 987

    Article  PubMed  CAS  Google Scholar 

  • Dawber T R, Wolf P A, Colton T, Nickerson R J (1977) Risk factors: Comparison of the biological data in myocardial and brain infarctions. In: Zülch K J, Kaufmann W, Hossmann K A, Hossmann V (eds) Brain and heart infarct. Springer-Verlag, Berlin-Heidelberg-New York, pp 226–252

    Google Scholar 

  • Dawson A A, Ogston D (1970) The influence of the platelet count on the incidence of thrombotic and haemorrhagic complications in polycythaemia vera. Postgrad Med J 46: 76–78

    CAS  Google Scholar 

  • DePasquale N P, Burch G E (1963) Hematocrit in women with myocardial infarction. JAMA 183: 142–143

    PubMed  CAS  Google Scholar 

  • Dintenfass L (1971) Blood microrheology — viscosity factors in blood flow, ischaemia and thrombosis. London, Butterworth, p 267

    Google Scholar 

  • Elwood P C, Sweetnam P, Mahler R, Moore F, Welsby E (1970) Association between circulating haemoglobin level, serum cholesterol, and blood pressure. Lancet is 589–590

    Google Scholar 

  • Elwood P C, Benjamin I T, Waters W E, Sweetnam P M (1974) Mortality and anaemia in women. Lancet is 891–894

    Google Scholar 

  • Gottstein U (1965) Physiologie and Pathophysiologie des Hirnkreislaufs. Med Welt 15: 715–726

    PubMed  CAS  Google Scholar 

  • Gottstein U (1978) Cerebral blood flow, CMRO2 and CMR glucose in patients with hypo and hyper chronic anaemia and polycythaemia. 9th Int. Salzburg Conf. on Cerebrovascular Disease (to be published)

    Google Scholar 

  • Hall C A (1965) Gaisbock’s disease: Redefinition of an old syndrome. Arch Intern Med 116: 4–9

    Article  PubMed  CAS  Google Scholar 

  • Heyman A, Patterson J L, Duke T W (1952) Cerebral circulation and metabolism in sickle cell and other chronic anaemias, with observations of the effects of oxygen inhalation. J Clin Invest 31: 824–828

    Article  PubMed  CAS  Google Scholar 

  • Humphrey P R D, du Boulay G H, Marshall J, Pearson T C, Ross Russell R W, Symon L, WetherleyMein G, Zilkha E (1979a) Cerebral blood flow and viscosity in relative polycythaemia. Lancet ii: 873–877

    Google Scholar 

  • Humphrey P R D, du Boulay G H, Marshall J, Pearson T C, Ross Russell R W, Slater N G P, Wetherley-Mein G, Zilkha E (1979b) Cerebral blood flow, haematocrit and viscosity in patients with paraproteinaemia: the importance of viscosity. (In preparation)

    Google Scholar 

  • Kannel W B, Gordan T, Wolf P A, McNamara P (1972) Hemoglobin and the risk of cerebral infarction: the Framingham study. Stroke 3: 409–420

    Article  PubMed  CAS  Google Scholar 

  • Kaung D T, Peterson R E (1962) Relative polycythemia or pseudopolycythemia. Arch Intern Med 110: 456–460

    Article  PubMed  CAS  Google Scholar 

  • Kety S S (1949) The physiology of the human cerebral circulation. Anesthesiology 10: 610–614

    Article  PubMed  CAS  Google Scholar 

  • Lawrence J H, Berlin N I (1952) Relative polycythemia — the polycythemia of stress. Yale J Biol Med 24: 498–505

    PubMed  CAS  Google Scholar 

  • Lawrence J H, Berlin N I, Huff R L (1953) The nature and treatment of polycythemia. Medicine (Baltimore) 32: 323–388

    CAS  Google Scholar 

  • Lundsgaard-Hansen P (1979) Haemodilution — New clothes for an anemic emperor. Vox Sang 36: 321–336

    Article  PubMed  CAS  Google Scholar 

  • McLachlin A D, McLachlin J A, Jory T A, Rawling E G (1960) Venous stasis in the lower extremities. Ann Surg 152: 678–685

    Article  PubMed  CAS  Google Scholar 

  • Mayer G A (1965) Hematocrit and coronary heart disease. Can med Ass J 93: 1151–1153

    PubMed  CAS  Google Scholar 

  • Merrill E W, Gilliland E R, Cokelet G, Shin H, Britten A, Wells R E (1963) Rheology of human blood, near and at zero flow. Effects of temperature and haematocrit level. Biophys J 3: 199–213

    Article  PubMed  CAS  Google Scholar 

  • Merrill E W, Margetts W G, Cokelet G R, Gilliland E R (1965) The Casson equation and rheology of blood near zero shear. Proc int Congr Rheology New York, Wiley and Sons, 135–143

    Google Scholar 

  • Nelson D, Fazekas J F (1956) Cerebral blood flow in polycythemia vera. Arch Intern Med 98: 328–331

    Article  Google Scholar 

  • Nicolaides A N, Horbourne T, Bowers R, Kidner P H, Besterman E M (1977) Blood viscosity, red-cell flexibility, haematocrit, and plasma fibrinogen in patients with angina. Lancet ii: 943–945

    Google Scholar 

  • Norman I L, Allen E V (1937) The vascular complications of polycythemia. Am Heart J 13: 257–273

    Article  Google Scholar 

  • O’Brien M D (1971) Some neurological aspects of dementia. Geriontologica Clinica 13: 339–349

    Article  Google Scholar 

  • Palmer A A (1966) Platelet and leucocyte skimming. 4th Europe Conf Microcirculation, Cambridge. Bibl Anat 9: 300–303

    Google Scholar 

  • Paulson O B, Henriksen L, Smith R J (1979) The effect of haemodilution on cerebral blood flow and blood gases in patients with polycythaemia. 9th Intern. CBF Symposium, Tokyo, pp 588–589

    Google Scholar 

  • Pearson T C (1977) Clinical and laboratory studies in the polycythaemias. M.D. Thesis (London University)

    Google Scholar 

  • Pearson T C, Ring C P (1976) Unpublished observations

    Google Scholar 

  • Pearson T C, Wetherley-Mein G (1978) Vascular occlusive episodes and venous haematocrit in primary proliferative polycythaemia. Lancet ii: 1219–1222

    Google Scholar 

  • Pearson T C, Weatherley-Mein G (1979) The course and complications of idiopathic erythrocytosis. J Clin Lab Haematol I: 189–196

    Google Scholar 

  • Preston F E, Emmanuel I G, Winfield D A, Malia R G (1974) Essential thrombocythaemia and peripheral gangrene. Br Med J 3: 548–552

    Article  PubMed  CAS  Google Scholar 

  • Russell R P, Conley C L (1964) Benign polycythemia: Gaisbock’s syndrome. Arch Intern Med 114: 734–740

    Article  PubMed  CAS  Google Scholar 

  • Scheinberg P (1949) The effects of postural changes, stellate ganglion block and anaemia on the cerebral circulation. J Clin Invest 28: 808–809

    Google Scholar 

  • Schmid-Schönbein H (1979) Rheological studies of the blood under normal and pathological conditions. In: Zülch K J, Kaufmann W, Hossmann K A, Hossmann V (eds) Brain and heart infarct. Berlin-Heidelberg-New York, Springer-Verlag, pp 96–106

    Google Scholar 

  • Sevitt S (1973) Recent advances in thrombosis. Edinburgh and London, Churchill Livingstone, p 33

    Google Scholar 

  • Shapiro B A (1973) The clinical application of blood gases. Year Book Publishers, Chicago, p 37

    Google Scholar 

  • Singh A K, Wetherley-Mein G (1977) Microvascular occlusive lesions in primary thrombocythaemia. Br J Haematol 36: 553–564

    Article  PubMed  CAS  Google Scholar 

  • Szur L, Lewis S M, Goolden A W G (1959) Polycythaemia vera and its treatment with radioactive phosphorus. Q J Med 29: 397–424

    Google Scholar 

  • Taylor G W, Calo A R (1962) Atherosclerosis of arteries of the lower limb. Br Med J 1: 507–510

    Article  PubMed  CAS  Google Scholar 

  • Thomas D J, du Boulay G H, Marshall J, Pearson T C, Ross Russell R W, Symon L, Wetherley-Mein G, Zilkha E (1977) Cerebral blood flow in polycythaemia. Lancet ii: 161–163

    Google Scholar 

  • Tohgi H, Yamanouchi H, Murakami M, Kameyama M (1978) Importance of the haematocrit as a risk factor in cerebral infarction. Stroke 9: 369–374

    Article  PubMed  CAS  Google Scholar 

  • Videbaek A (1950) Polycythaemia vera; course and prognosis. Acta Med Scand 138: 179–187

    Article  PubMed  CAS  Google Scholar 

  • Weinreb N J, Shih C-F (1975) Spurious polycythemia. Semin Hematol 12: 397–407

    PubMed  CAS  Google Scholar 

  • Yates C J P, Andrews V, Berent A, Dormandy J A (1979) Increase in leg blood-flow by normovolaemic haemodilution in intermittent claudication. Lancet ii: 166–168

    Google Scholar 

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© 1981 Spring-Verlag Berling Heidelberg

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Pearson, T.C., Humphrey, P.R.D., Thomas, D.J., Wetherley-Mein, G. (1981). Haematocrit, Blood Viscosity, Cerebral Blood Flow, and Vascular Occlusion. In: Lowe, G.D.O., Barbenel, J.C., Forbes, C.D. (eds) Clinical Aspects of Blood Viscosity and Cell Deformability. Springer, London. https://doi.org/10.1007/978-1-4471-3105-2_10

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  • DOI: https://doi.org/10.1007/978-1-4471-3105-2_10

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3107-6

  • Online ISBN: 978-1-4471-3105-2

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