Prediction of dependence-producing potential of a new drug

  • Peter I. Folb


The clinical state of drug dependence in man is a condition of periodic or chronic intoxication produced by the repeated consumption of a drug.


Drug Dependence Physical Dependence Abstinence Syndrome Chronic Intoxication Morphine Dependence 
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Selective Bibliography

  1. Bewley TM (1972) Drug dependence caused by medical treatment. In: Meyler L, Peck HM (eds) Drug-induced diseases, vol 4. Excerpta Medica, Amsterdam, p 571Google Scholar
  2. Eddy NB, Halbach H, Isbell M, Seevers MH (1965) Drug dependence: Its significance and characteristics. Bull WHO 32: 721PubMedGoogle Scholar
  3. Halbach H, Eddy NB (1963) Tests for addiction (chronic intoxication) of morphine type. Bull WHO 28: 139PubMedGoogle Scholar
  4. Marks J (1978) The benzodiazepines. Use, overuse, misuse, abuse. MTP Press, Lancaster, EnglandGoogle Scholar
  5. World Health Organisation (1964) Evaluation of dependence-producing drugs. WHO Tech Rep Ser 287Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • Peter I. Folb
    • 1
    • 2
  1. 1.University of Cape TownSouth Africa
  2. 2.Groote Schuur HospitalCape TownSouth Africa

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