Neutrophil CD11b Expression in Patients with Venous Disease

  • D. A. Shields
  • M. Saharay
  • C. A. Timothy-Antoine
  • J. B. Porter
  • J. H. Scurr

Abstract

The white cell trapping hypothesis suggests that raised venous pressure causes white cell margination and activation, with the release of proteolytic enzymes and Superoxide radicals, believed responsible for the tissue destruction seen in chronic venous insufficiency [1]. We have demonstrated raised levels of plasma lactoferrin [2] and elastase [3] as markers of neutrophil degranulation in patients with venous disease previously.

Keywords

Migration Superoxide Integrin 

References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • D. A. Shields
    • 1
  • M. Saharay
    • 1
  • C. A. Timothy-Antoine
    • 1
    • 2
  • J. B. Porter
    • 1
    • 2
  • J. H. Scurr
    • 1
  1. 1.Department of SurgeryUCLMS, The Middlesex HospitalLondonUK
  2. 2.Department of HaematologyUCLMS, The Middlesex HospitalLondonUK

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