Soft-Tissue Sarcoma

  • Peter Frey

Abstract

Soft-tissue sarcomas are malignant mesenchymal or soft-tissue tumours that not only behave aggressively with infiltrative growth at the site of the tumour — as most soft-tissue tumours do — but also metastasize and show a definite malignant histological pattern, which is often difficult to determine with certainty. Soft-tissue sarcomas are thought to originate from undifferentiated mesenchymal cells, being the initial cells for the development of connective tissue, muscle, fat, tendon and nerve tissue, as well as vascular and lymphatic structures. The undifferentiated initial mesenchymal cells can either develop into differentiated cells of the above-mentioned soft tissues, becoming malignant secondarily, or become malignant in the undifferentiated state or in a state that does not allow recognition of the cell line they belong to. These tumours are classified as undifferentiated sarcoma. A simplified adaptation to the neonatal age group of the classification of benign and malignant soft-tissue tumours by Stout and Lattes1 and Krementz and Munchmore2 is shown in Table 7.1.

Keywords

Oncol Sarcoma Cyclophosphamide Etoposide Vincristine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Stout AP, Lattes RL (1966) Atlas of tumour pathology, second series, fascicle 1, Tumours of the soft tissues. Armed Force Institute of Pathology, Washington, DC p 14.Google Scholar
  2. Krementz ET, Munchmore MD (1983) Soft tissue sarcomas. Behaviour and management. Adv Surg 16: 147–196.Google Scholar
  3. 3.
    Gorman PA, Malone M, Pritchard J, Sheer D (1990) Deletion of part of the short arm of chromosome 17 in a congenital fibrosarcoma. Cancer Genet Cytogenet 48: 193–198.PubMedCrossRefGoogle Scholar
  4. 4.
    Speleman F, Dalcin P, De Potter K et al. (1989) Cytogenetic investigation of a case of congenital fibrosarcoma. Cancer Genet Cytogenet 39: 21–24.PubMedCrossRefGoogle Scholar
  5. 5.
    Perk K, Maloney JB, Jenkins EG (1967) Further studies on the relationship of a rhabdomyosarcoma virus to muscle tissue. Int J Cancer 22: 43.CrossRefGoogle Scholar
  6. 6.
    Pettit VE, Chamness JT, Ackermann LV (1954) Fibromatosis and fibrosarcoma following irradiation therapy. Cancer 7: 149.PubMedCrossRefGoogle Scholar
  7. 7.
    Gatti RA, Good RA (1971) Occurrence of malignancy in immunodeficiency disease: a literature review. Cancer 28: 89–98.PubMedCrossRefGoogle Scholar
  8. 8.
    Bader JL, Miller RW (1979) US cancer incidence and mortality in the first year of life. Am J Dis Child 133: 157–159.PubMedGoogle Scholar
  9. 9.
    Barson AJ (1978) Congenital neoplasia: the society’s experience. Arch Dis Child 53: 436.Google Scholar
  10. 10.
    Gale GB, D’Angio GJ, Uri A, Chatten J, Koop CE (1982) Cancer in neonates: the experience at the Children’s Hospital of Philadelphia. Pediatrics 7: 409–413.Google Scholar
  11. 11.
    Isaacs HJ (1985) Perinatal (congenital and neonatal) neoplasms: a report of 110 cases. Pediatr Pathol 3: 165–216.PubMedCrossRefGoogle Scholar
  12. 12.
    Campbell AN, Chan HS, O’Brien A, Smith CR, Becker LE (1987) Malignant tumours in the neonate. Arch Dis Child 62: 19–23.PubMedCrossRefGoogle Scholar
  13. 13.
    Fraumeni JF, Miller RW (1969) Cancer death in the newborn. Am J Dis Child 117: 186–189.PubMedGoogle Scholar
  14. 14.
    Davis CF, Carachi R, Young DG (1988) Neonatal tumours: Glasgow 1955–86. Arch Dis Child 63: 1075–1078.PubMedCrossRefGoogle Scholar
  15. 15.
    Coffin CM, Dehner LP (1990) Soft tissue tumours in first year of life. A report of 190 cases. Pediatr Pathol 10: 509–526.PubMedCrossRefGoogle Scholar
  16. 16.
    Salloum E, Flamant F, Caillaud JM et al. (1990) Diagnostic and therapeutic problems of soft tissue tumors other than rhabdomyosarcoma in infants under one year of age: a clinicopathological study of 34 cases treated at the Institute Gustave Roussy. Med Pediatr Oncol 18: 37–43.PubMedCrossRefGoogle Scholar
  17. 17.
    Pautard B, Canarelli JP, Gontier MF, Risbourg B, Piussan C, Flamant F (1990) Rhabdomyosarcoma embryonnaire de découverte anténatale. Arch Fr Pediatr 47: 433–435.PubMedGoogle Scholar
  18. 18.
    Huth JF, Gupta RK, Morton DL (1981) Development of an enzyme immunoassay to detect and quantitate tumor-associated antigens in the urine of sarcoma patients. Cancer 47: 2856–2861.PubMedCrossRefGoogle Scholar
  19. 19.
    Barbet JP, Kurzenne JY, Butler-Browne GS, Mouly V, Laurent M, Gubler JP (1989) Rhabdomyosarcoma de decouverte neonatale. Etude des marqueurs de differenciation musculaire. Ann Pathol 9: 363–368.Google Scholar
  20. 20.
    Clinical conference (1994) Small-round-cell tumours of child-hood. Lancet 344: 725–729.CrossRefGoogle Scholar
  21. 21.
    Enneking WF, Spanier SS, Malawar MM (1981) The effect of the anatomic setting on the results of surgical procedures for soft parts sarcoma of the thigh. Cancer 47: 1005–1022.PubMedCrossRefGoogle Scholar
  22. 22.
    Russel WD, Cohen J, Edmonson JH (1981) Staging system for soft tissue sarcoma. Semin Oncol 8: 156.Google Scholar
  23. 23.
    Soule EH, Pritchard DJ (1977) Fibrosarcoma in infants and children. A review of 110 cases. Cancer 40: 1711–1721.PubMedCrossRefGoogle Scholar
  24. 24.
    Balsaver AM, Butler J, Martin RG (1967) Congenital fibrosarcoma. Cancer 20: 1607–1616.PubMedCrossRefGoogle Scholar
  25. 25.
    Chung EB, Enzinger FM (1976) Infantile fibrosarcoma. Cancer 38: 729–739.PubMedCrossRefGoogle Scholar
  26. 26.
    Gonzalez-Crussi F, Wiederhold MD, Sotelo-Avida C (1980) Congenital fibrosarcoma: presence of a histiocytic component. Cancer 46: 77–86.PubMedCrossRefGoogle Scholar
  27. 27.
    Enzinger FM, Weiss SW (1983) Soft tissue tumors, 2nd edn. CV Mosby, St. Louis, pp 115–124.Google Scholar
  28. 28.
    Blocker S, Koenig J, Ternberg J (1987) Congenital fibrosar-coma. J Pediatr Surg 22: 665–760.PubMedCrossRefGoogle Scholar
  29. 29.
    Iwasaki H, Enjoji M (1979) Infantile and adult fibrosarcomas of the soft tissues. Acta Pathol Jpn 29: 377–388.PubMedGoogle Scholar
  30. 30.
    Martell JR, Brusnardo MS, Barja RH, Gordon F (1986) Congenital fibrosarcoma of the forearm. A case report. J Bone Joint Surg 68: 620–623.Google Scholar
  31. 31.
    Tarsitano BF (1990) Oral infantile fibrosarcoma: report of a case. J Oral Maxillofac Surg 48: 1228–1230.PubMedCrossRefGoogle Scholar
  32. 32.
    Desrousseaux B, Gourdin C, Atat I et al. (1989) Fibrosarcome pulmonaire neonatal. Chir Pediatr 30: 295–296.PubMedGoogle Scholar
  33. 33.
    Stout AP (1962) Fibrosarcoma in infants and children. Cancer 15: 1028–1040.PubMedCrossRefGoogle Scholar
  34. 34.
    Ninane J, Gosseye S, Panteon E, Claus D, Rombouts JJ, Cornu G (1986) Congenital fibrosarcoma. Preoperative chemotherapy and conservative surgery. Cancer 58: 1400–1406.Google Scholar
  35. 35.
    Dehner LP (1981) Neoplasms of the fetus and neonate. In: Naeye RL, Kissane JM, Kauffman N, eds. Perinatal disease. Monographs in pathology 22. Williams and Wilkins, Baltimore, 286–346.Google Scholar
  36. 36.
    Coffin CM, Jaszcz W, O’Shea PA, Dehner LP (1994) So called congenital infantile fibrosarcoma: does it exist and what is it? Pediatr Pathol 14: 133–150.PubMedCrossRefGoogle Scholar
  37. 37.
    Flamant F, Hill C (1984) The improvement in survival associated with combined chemotherapy in childhood rhabdomyosarcoma: a historical comparison of 345 patients in the same center. Cancer 53: 2417–2421.PubMedCrossRefGoogle Scholar
  38. 38.
    Hays DM, Mirabal VQ, Karlan MS, Patel HR, Landing BH (1970) Fibrosarcomas in infants and children. J Pediatr Surg 5: 176–183.PubMedCrossRefGoogle Scholar
  39. 39.
    Stout AP (1946) Rhabdomyosarcoma of the skeletal muscles. Ann Surg 123: 447–472.CrossRefGoogle Scholar
  40. 40.
    Dias P, Kumar P, Marsden HB et al. (1987) Evaluation of desmin as a diagnostic and a prognostic marker of childhood rhabdomyosarcomas and embryonal sarcomas. Br J Cancer 56: 361–365.PubMedCrossRefGoogle Scholar
  41. 41.
    Ragab AH, Heyn R, Tefft M, Hays DN, Newton WAJ, Beltangady M (1986) Infants younger than 1 year of age with rhabdomyosarcoma. Cancer 58: 2606–2610.PubMedCrossRefGoogle Scholar
  42. 42.
    Li PF, Fraumeni JF (1969) Rhabdomyosarcoma in children: epidemiologic study and identification of familial cancer syndrome. J Natl Cancer Inst 43: 1365–1373.PubMedGoogle Scholar
  43. 43.
    Kauffman SL, Stout AP (1956) Congenital mesenchymal tumors. Cancer 18: 460–476.CrossRefGoogle Scholar
  44. 44.
    Palmer NF, Foulkes MA, Sachs N, Newton WA (1983) Rhabdomyosarcoma: a cytological classification of prognostic significance. Proc Am Soc Clin Oncol 2: 229.Google Scholar
  45. 45.
    Kudet R, Newton WA Jr, Hamoudi AB, Asmar L, Jacobs DL, Maurer HM (1993) Childhood rhabdomyosarcoma with anaplastic (pleomorphic) features: a report of the Intergroup Rhabdomyosarcoma Study. Am J Surg Oncol 17: 443–453.Google Scholar
  46. 46.
    Maurer HM, Beltangady M, Gehan EA, Crist W, Hammond D (1988) The Intergroup Rhabdomyosarcoma Study-1. A final report. Cancer 61: 209–220.Google Scholar
  47. 47.
    Freeman AI, Woods G (1990) Genitourinary tumors. In: Ashcraft KW, ed. Pediatric urology. WB Saunders, Philadelphia, pp 449–456.Google Scholar
  48. 48.
    Littman P, D’Angio GJ (1981) Radiation therapy in the neonate. AM J Pediatr Hematol Oncol 3: 279–285.PubMedGoogle Scholar
  49. 49.
    Li FP, Cassady JR, Jaffe N (1975) Risk of second tumour in survivors of childhood cancer. Cancer 35: 1230–1235.PubMedCrossRefGoogle Scholar
  50. 50.
    Siegel SE, Moran RG (1981) Problems in the chemotherapy of cancer in the neonate. Am J Pediatr Hematol Oncol 3: 287–296.PubMedGoogle Scholar
  51. 51.
    Koscielniak E, Harms D, Schmidt D et al. (1989) Soft tissue sarcomas in infants younger than 1 year of age: a report of the German soft tissue sarcoma study group (CWS-81). Med Pediatr Oncol 17: 105–113.PubMedCrossRefGoogle Scholar
  52. 52.
    Shimada H, Newton WA, Soule EH, Beltangady MS, Maurer HM (1987) Pathology of fatal rhabdomyosarcoma. Report from the Intergroup Rhabdomyosarcoma Study. Cancer 59: 459–465.Google Scholar
  53. 53.
    Ruymann BF, Maddux RH, Ragab A (1988) Congenital anomalies associated with rhabdomyosarcoma: an autopsy study in 115 cases. Med Pediatr Oncol 16: 33–39.PubMedCrossRefGoogle Scholar
  54. 54.
    Molenaar WM, Oosterhuis JW, Ramakaers FCS (1985) Mesenchymal and muscle-specific intermediate filaments (vimentin and desmin) in relation to differentiation in childhood rhabdomyosarcomas. Hum Pathol 16: 838–843.PubMedCrossRefGoogle Scholar
  55. 55.
    Stout AP, Murray MR (1942) Hemangiopericytoma. A vascular tumor featuring Zimmerman’s pericyte. Ann Surg 116: 26–33.Google Scholar
  56. 56.
    Seibert JJ, Seibert RW, Weisenburger DS, Allsbrook W (1978) Multiple congenital hemangiopericytomas of the head and neck. Laryngoscope 88: 1006–1012.PubMedCrossRefGoogle Scholar
  57. 57.
    Maillet P, Lamesch A, Dawagne MP (1985) L’hénangiopericytome congenital: a propos de deux cas personnels. Revue de la litterature. Chir Pediatr 26: 22–25.Google Scholar
  58. 58.
    Enterline HT (1981) Histopathology of sarcomas. Semin Oncol 8: 133.PubMedGoogle Scholar
  59. 59.
    Chen KTK, Kassel SH, Medrano VA (1986) Congenital hemangiopericytoma. J Surg Oncol 31: 127–129.PubMedCrossRefGoogle Scholar
  60. 60.
    Atkinson JB, Mahour GH, Issacs H, Ortega JA (1984) Hemangiopericytoma in infants and children. A report of six patients. Am J Surg 48: 372–374.Google Scholar
  61. 61.
    Wong PP, Yagoda A (1978) Chemotherapy of malignant hemangiopericytoma. Cancer 41: 1256–1260.PubMedCrossRefGoogle Scholar
  62. 62.
    Hollmann G, Heopner F, Daum R, Stuhlinger M (1972) Beitrag zur Klinik des Hamangioperizytoms. Langenbecks Arch Klin Chir 330: 128.Google Scholar
  63. 63.
    Angerpointer TA, Weitz H, Haas RJ, Hecker WC (1981) Intestinal leiomyosarcoma in childhood - case report and review of the literature. J Pediatr Surg 16: 491–495.CrossRefGoogle Scholar
  64. 64.
    Akwarei OE, Dozois RR, Weiland LH, Beahrs OH (1978) Leiomyosarcoma of the small and large bowel. Cancer 42: 1375–1384.CrossRefGoogle Scholar
  65. 65.
    Pinedo HM (1977) Chemotherapy of advanced soft tissue sarcomas in adults. Cancer Treat Rev 4: 67–86.PubMedCrossRefGoogle Scholar
  66. 66.
    Sztankay C (1959) Geheiltes Rektumsarkom im Kindesalter. Zentralbl Chir 84: 826–830.PubMedGoogle Scholar
  67. 67.
    Kriss N (1960) Leiomyosarcoma of the colon in an infant. Am J Roentgenol Radiat Ther Nucl Med 84: 540–545.Google Scholar

Copyright information

© Springer-Verlag London Limited 1996

Authors and Affiliations

  • Peter Frey

There are no affiliations available

Personalised recommendations