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Preimplantation Genetic Diagnosis and HLA-Typing: The Potential for Selection of Unaffected HLA Matched Siblings

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Preimplantation Genetic Diagnosis in Clinical Practice

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Abstract

Haematopoietic stem cell transplantation (HSCT or bone marrow transplantation) is an effective treatment for many disorders of the haematopoietic system and has the potential to offer a cure for life. It is therefore an important treatment option, and for some genetic conditions may be the only option available. Numerous reports show that the best survival outcomes are achieved when a sibling who has the same genetic HLA type as the patient is available. Preimplantation HLA typing provides the opportunity in specific cases to select an HLA-matched unaffected embryo that may be a suitable HSCT donor for an affected sibling using umbilical cord blood collected from the placenta at the time of birth. When the procedure of cord blood collection is unsuccessful, ethical issues are raised about bone marrow harvest from the ‘saviour sibling’.

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Author information

Authors and Affiliations

  1. Department of Immunology and Bone Marrow Transplant, Paediatric Nurse Practitioner-Immunology and Bone Marrow Transplant, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street Hospital, Great Ormond Street, London, WC1N 3JH, UK

    Lucie Brown BSC, Children’s Nursing

  2. Molecular Immunology Unit, Great Ormond Street Hospital and UCL Institute of Child Health, 30, Guilford Street, London, WC1N, UK

    H. Bobby Gaspar MBBS, MRCP(UK), MRCPCH, PhD

Authors
  1. Lucie Brown BSC, Children’s Nursing
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  2. H. Bobby Gaspar MBBS, MRCP(UK), MRCPCH, PhD
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Corresponding author

Correspondence to Lucie Brown BSC, Children’s Nursing .

Editor information

Editors and Affiliations

  1. Assisted Conception Unit, Guy's and St. Thomas Hospital, London, United Kingdom

    Tarek El-Toukhy

  2. Department of Women’s Health, King’s College, London, United Kingdom

    Peter Braude

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© 2014 Springer-Verlag London

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Brown, L., Gaspar, H.B. (2014). Preimplantation Genetic Diagnosis and HLA-Typing: The Potential for Selection of Unaffected HLA Matched Siblings. In: El-Toukhy, T., Braude, P. (eds) Preimplantation Genetic Diagnosis in Clinical Practice. Springer, London. https://doi.org/10.1007/978-1-4471-2948-6_13

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  • DOI: https://doi.org/10.1007/978-1-4471-2948-6_13

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-2947-9

  • Online ISBN: 978-1-4471-2948-6

  • eBook Packages: MedicineMedicine (R0)

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