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PGD Facts and Figures

Chapter

Abstract

The first live birth after PGD Centre at Guy’s and St. Thomas’ NHS Hospital was in 1998 to avoid spinal muscular atrophy (SMA) and used a polymerase chain reaction (PCR)-based test. The programme has progressively grown over time and in 2012 undertook over 220 cycles per annum making it one of the most active PGD centres in Europe. Single-gene disorders represent 60 % of the current indications for PGD, with three quarters of cycles started reaching embryo transfer. About 40 % of PGD embryo transfers will result in a clinical pregnancy. Female age and ovarian reserve are strong predictors of PGD success. Single blastocyst transfer and cryopreservation of surplus blastocyst(s) is an effective strategy to reduce the multiple pregnancy rate in a PGD programme.

Keywords

Embryo Transfer Spinal Muscular Atrophy Clinical Pregnancy Preimplantation Genetic Diagnosis Ovarian Reserve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Further Reading

  1. El-Toukhy T, Kamal A, Wharf E, et al. Reduction of the multiple pregnancy rate in a preimplantation genetic diagnosis programme after introduction of single blastocyst transfer and cryopreservation of blastocysts biopsied on day 3. Hum Reprod. 2009;24:2642–8.PubMedCrossRefGoogle Scholar
  2. Grace J, El-Toukhy T, Scriven P, et al. Three hundred and thirty cycles of preimplantation genetic diagnosis for serious genetic disease: clinical considerations affecting outcome. Br J Obstet Gynaecol. 2006;113:1393–401.CrossRefGoogle Scholar
  3. Harper J, Wilton L, Traeqer-Synodinos J, et al. The ESHRE PGD consortium: 10 years of data collection. Hum Reprod Update. 2012;18:234–47.PubMedCrossRefGoogle Scholar
  4. Pickering S, Polidoropoulos N, Caller J, et al. Preimplantation Genetic Diagnosis Study Group. Strategies and outcomes of the first 100 cycles of preimplantation genetic diagnosis at the Guy’s and St. Thomas’ Center. Fertil Steril. 2003;79:81–90.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  1. 1.Assisted Conception Unit and PGD CentreGuy’s and St. Thomas’ Hospital NHS Foundation TrustLondonUK

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