Beneficial Effects of Intermittent Normobaric Hypoxic Training on Respiratory Function in Patients with Chronic Pulmonary Diseases

  • Mikhail I. LevashovEmail author


In this chapter, we present the results of our studies regarding the INHT effects on respiratory functions in 103 high-risk chronic obstructive pulmonary disease (COPD) patients, 157 bronchial asthma (BA) patients, and 36 healthy individuals. Patients ranged in age from 21 to 59 years (women – 52.1%, men – 47.9%). INHT was carried out in “Orotron” chamber under such environmental parameters: PO2 – 147–160 hPa, relative humidity – 60–70%, ambient temperature – 16–18°C, and content of light negative ions – up to 6,000/cm3. All patients received daily 90 min of INHT alone or INHT in combination with conventional therapy for 2–4 weeks. Total time of hypoxic gas mixture breathing for the whole INHT course ranged from 21 to 42 h. We performed pulmonary function tests in all patients before, during, and after INHT. Results of our studies indicated that INHT increased reserves of lung ventilation and restored the physiological level of alveolar ventilation in 78% of patients with COPD, optimized regional air distribution in lung, and decreased by 25–30% the lung ventilation unevenness. INHT reduced the bronchial resistivity by 31–37% in BA patients and changed the respiratory regulation in COPD patients and healthy individuals. It contributed to more complete restoration of the optimal structure of respiratory pattern. Further investigations will allow INHT to emerge as an important nonpharmacological therapy for care and rehabilitation of patients with pulmonary diseases.


Chronic Obstructive Pulmonary Disease Chronic Obstructive Pulmonary Disease Patient Bronchial Asthma Patient Functional Residual Capacity Inspiratory Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Bronchial asthma


Central inspiratory activity


Chronic obstructive pulmonary diseases


Respiratory rate


Expiratory reserve volume


Volume at the end of the first second of forced expiration


Maximum instantaneous flow achieved during FVC maneuver


Average flow from the point were 25% of the FVC has been exhaled


Average flow from the point were 50% of the FVC has been exhaled


Average flow from the point were 75% of the FVC has been exhaled


Functional residual capacity


Forced vital capacity


Airway conductance


Intermittent normobaric hypoxic training


Inspiratory reserve volume


Maximal voluntary ventilation


Ratio of respiratory reserve


Partial pressure of oxygen


Maximal inspiratory pressure


Airway resistance


Inspiratory time of one respiratory cycle


Expiratory time of one respiratory cycle


Total duration of respiratory cycle


Proportion of inspiration phase in total duration of respiratory cycle or “useful cycle” of breathing


Time respiratory quotient


Alveolar ventilation/min


Vital capacity


Expired volume/min


Tidal volume


Mean rate of inspiratory flow of one breath


Mean rate of expiratory flow of one breath

VI max/tI

Maximum rate of inspiratory flow of one breath

VE max/tE

Maximum rate of expiratory flow of one breath


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Copyright information

© Springer-Verlag London 2012

Authors and Affiliations

  1. 1.National Academy of Sciences of UkraineA.A. Bogomoletz Institute of PhysiologyKievUkraine

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