Pathophysiology of Venous Disease
As the Twentieth Century faded away and the new century began most of the dogma surrounding venous disorders faded away with the memories of the century past. The basis for this shift in attitude and approach had been laid years earlier by the development first of the continuous wave Doppler and then the Duplex Doppler. As applied to venous disease, this led first to the development of accurate diagnosis and then to uncovering the faults of existing therapy. Diagnosis of venous reflux and identification the faulty segments of venous dysfunction developed in the vascular laboratories of Strandness  and then Nicolaides . Very quickly, the mysteries of venous physiology and Pathophysiology were revealed (Table 4.1).
KeywordsObesity Migration Integrin Macromolecule Catecholamine
- 2.Vasdekis SN, Clarke GH, Nicolaides AN. Quantification of venous reflux by means of duplex scanning. J Vasc Surg. 1989;10:670–7; Lurie F, Kistner RL, Eklof B, Kessler D. Mechanism of venous valve closure and role of the valve in circulation: a new concept. J Vasc Surg. 2003;38:955–61.Google Scholar
- 7.Arnoldi CC. The function of the venous pump in chronic venous insufficiency: a phlebographic study. J Cardiovasc Surg. 1961;2:116–27.Google Scholar
- 14.Hoshino S, Satokawa H, Ono T, Igari T. Surgical treatment for varicose veins of the legs using intraoperative angioscopy. In: Raymond-Martimbeau P, Prescott R, Zummo M, editors. Phlebologie 92. Paris: John Libbey Eurotext; 1992. p. 1083–5.Google Scholar
- 15.Coleridge Smith PD. Treatment of microcirculation disorders in venous leg ulcer. In Messmer K (ed): Microcirculation in Chronic Venous Insufficiency. Prog Appl Microcirc. Basel, Karger, 1999;23:121–141.Google Scholar
- 16.Bergan JJ. Leucocytes and venous valve damage in chronic venous desease. Medicographia. 2006;28(2):101–8.Google Scholar