Abstract
There are several limitations in the understanding of the pathophysiology of heart failure and in defining therapeutic strategies for the same. This is a result of existing lacunae in the understanding of the normal structure and function of the heart in vivo, as well as the molecular and genetic factors influencing crucial steps toward altered geometry and function. Despite the presence of regional inhomogeneity in the normal left ventricle during systole and diastole, a highly effective global function is maintained. This is due to its structural and functional anisotropy.
With permission from Adhyapak SM and Parachuri VR. Architecture of the left ventricle: insights for optimal surgical ventricular restoration. Heart Failure Reviews 2010;15(1):73–83. Copyright Springer Science+ Business Media.
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Parachuri, V.R., Adhyapak, S.M. (2012). Anatomy of the Myocardium in the Normal Left Ventricle. In: Ventricular Geometry in Post-Myocardial Infarction Aneurysms. Springer, London. https://doi.org/10.1007/978-1-4471-2861-8_1
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