Embryology of the Penis

  • R. Guy HudsonEmail author
  • Michele Ebbers


Since the penis and its accouterments develop over time as a fusing of the urogenital membrane, it is particularly predisposed to congenital anomalies. Thus, understanding the development of the male genitalia is key to identifying congenital anomalies – many of which are grounds for deferring newborn circumcision.


Male Genitalia Male Phenotype Glans Penis Urethral Plate Penile Shaft 
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  1. 1.
    Greenfield A, Koopman P. SRY and mammalian sex determination. Curr Top Dev Biol. 1996;34:1–23.PubMedCrossRefGoogle Scholar
  2. 2.
    Baskin LS. Hypospadias and urethral development. J Urol. 2000;163:951–6.PubMedCrossRefGoogle Scholar
  3. 3.
    Kurzrock EA, Baskin LS, Cunha GR. Ontogeny of the male urethra: theory of endodermal differentiation. Differentiation. 1999;64:115–22.PubMedCrossRefGoogle Scholar
  4. 4.
    Felix W. The development of the urogenital organs. In: Keibel F, Mall FP, editors. Manual of human embryology, vol. 2. Philadelphia/London: Lippincott; 1912.Google Scholar
  5. 5.
    Siddiqi MAH. The development of the penile urethra and the homology of Cowper’s gland of male spermophile (Citellus tridecemlineatus) with a note on the prostatic urtricle. J Anat (Lond). 1937;72:109–15.Google Scholar
  6. 6.
    Wood Jones F. The development and malformation of the glans and prepuce. Br Med J. 1910;1(2559):137–8.CrossRefGoogle Scholar
  7. 7.
    Barnstein NJ, Mossman HW. The origin of the penile urethra and bulbo-urethral glands with particular reference to the red squirrel (Tamiasciurus hudsonicus). Anat Rec. 1938;72:67–85.CrossRefGoogle Scholar
  8. 8.
    Williams DI. The development and abnormalities of the penile urethra. Acta Anat. 1952;15:176–87.PubMedCrossRefGoogle Scholar
  9. 9.
    Martin RD. Primate origins and evolution: a phylogenic reconstruction. Princeton: Princeton University Press; 1990.Google Scholar
  10. 10.
    Gairdner D. The fate of the foreskin. Br Med J. 1949;2:1433–7.PubMedCrossRefGoogle Scholar
  11. 11.
    Parkash S, Raguram R, Venkatesan K, et al. Sub-preputial wetness – it’s nature. Ann Nat Med Sci (India). 1982;18(3):109–12.Google Scholar
  12. 12.
    Lee-Huang S, Huang PL, Sun Y, et al. Lysozyme and RHases as anti-HIV components in beta-core ­preparations of human chorionic gonadotropin. Proc Natl Acad Sci. 1999;96(6):2678–81.PubMedCrossRefGoogle Scholar
  13. 13.
    DeWitte L, Nabotov A, Pion M, et al. Langerin is a natural barrier to HIV-1 transmission by langerhans cells. Nat Med. 2007;13:367–71.CrossRefGoogle Scholar
  14. 14.
    Hsieh TF, Chang CH, Chang SS. Foreskin development before adolescence in 2149 schoolboys. Int J Urol. 2006;13:968–70.PubMedCrossRefGoogle Scholar
  15. 15.
    Kayaba H, Tamura H, Kitajima S, et al. Analysis of shape and retractability of the prepuce in 603 Japanese boys. J Urol. 1996;156:1813–5.PubMedCrossRefGoogle Scholar
  16. 16.
    Oster J. Further fate of the foreskin. Arch Dis Child. 1968;43:200.PubMedCrossRefGoogle Scholar
  17. 17.
    Cold CJ, Taylor JR. The prepuce. Br J Urol. 1999;83 Suppl 1:34–44.Google Scholar

Copyright information

© Springer-Verlag London 2012

Authors and Affiliations

  1. 1.Department of Pediatric Urologic SurgerySwedish Medical CenterSeattleUSA

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