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Maternal Obesity and Implications for the Long-Term Health of the Offspring

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Obesity During Pregnancy in Clinical Practice

Abstract

The current epidemic of obesity among women of childbearing age has serious implications for both the woman and her potential offspring. The adverse pregnancy outcomes associated with maternal obesity, as well as the long-term implications for the mothers’ health, are well established. However, there is increasing evidence indicating that offspring of obese mothers have an increased risk of obesity, cardiometabolic risk, adverse neurodevelopmental outcomes, and respiratory challenges, which follow them all the way to adulthood. This chapter provides clinicians and researchers with an overview of the long-term health implications for offspring exposed to maternal obesity.

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References

  1. Kim SY, Dietz PM, England L, Morrow B, Callaghan WM. Trends in pre-pregnancy obesity in nine states, 1993–2003. Obesity. 2007;15(4):986–93. PubMed PMID: 17426334.

    Article  PubMed  Google Scholar 

  2. Chu SY, Kim SY, Bish CL. Prepregnancy obesity prevalence in the United States, 2004–2005. Matern Child Health J. 2009;13(5):614–20. PubMed PMID: 18618231.

    Article  PubMed  Google Scholar 

  3. Barker DJ. Developmental origins of adult health and disease. J Epidemiol Community Health. 2004;58(2):114–5. PubMed PMID: 14729887. Pubmed Central PMCID: 1732687.

    Article  PubMed  CAS  Google Scholar 

  4. Forsdahl A. Are poor living conditions in childhood and adolescence an important risk factor for arteriosclerotic heart disease? Br J Prev Soc Med. 1977;31(2):91–5. PubMed PMID: 884401. Pubmed Central PMCID: 479002.

    PubMed  CAS  Google Scholar 

  5. Alfaradhi MZ, Ozanne SE. Developmental programming in response to maternal overnutrition. Front Genet. 2011;2:27. PubMed PMID: 22303323. Pubmed Central PMCID: 3268582.

    Article  PubMed  Google Scholar 

  6. Ong KK, Dunger DB. Perinatal growth failure: the road to obesity, insulin resistance and cardiovascular disease in adults. Best Pract Res Clin Endocrinol Metab. 2002;16(2):191–207. PubMed PMID: 12064888.

    Article  PubMed  CAS  Google Scholar 

  7. Hales CN, Barker DJ. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia. 1992;35(7):595–601. PubMed PMID: 1644236.

    Article  PubMed  CAS  Google Scholar 

  8. Drake AJ, Reynolds RM. Impact of maternal obesity on offspring obesity and cardiometabolic disease risk. Reproduction. 2010;140(3):387–98. PubMed PMID: 20562299.

    Article  PubMed  CAS  Google Scholar 

  9. Taylor PD, Poston L. Developmental programming of obesity in mammals. Exp Physiol. 2007;92(2):287–98. PubMed PMID: 17170060.

    Article  PubMed  CAS  Google Scholar 

  10. Whitaker RC. Predicting preschooler obesity at birth: the role of maternal obesity in early pregnancy. Pediatrics. 2004;114(1):e29–36. PubMed PMID: 15231970.

    Article  PubMed  Google Scholar 

  11. Boney CM, Verma A, Tucker R, Vohr BR. Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics. 2005;115(3):e290–6. PubMed PMID: 15741354.

    Article  PubMed  Google Scholar 

  12. Laitinen J, Jaaskelainen A, Hartikainen AL, Sovio U, Vaarasmaki M, Pouta A, et al. Maternal weight gain during the first half of pregnancy and offspring obesity at 16 years: a prospective cohort study. BJOG. 2012;119(6):716–23. PubMed PMID: 22489762.

    Article  PubMed  CAS  Google Scholar 

  13. Lake JK, Power C, Cole TJ. Child to adult body mass index in the 1958 British birth cohort: associations with parental obesity. Arch Dis Child. 1997;77(5):376–81. PubMed PMID: 9487953.

    Article  PubMed  CAS  Google Scholar 

  14. Reilly JJ, Armstrong J, Dorosty AR, Emmett PM, Ness A, Rogers I, et al. Early life risk factors for obesity in childhood: cohort study. BMJ. 2005;330(7504):1357. PubMed PMID: 15908441. Pubmed Central PMCID: 558282.

    Article  PubMed  Google Scholar 

  15. Stuebe AM, Forman MR, Michels KB. Maternal-recalled gestational weight gain, pre-pregnancy body mass index, and obesity in the daughter. Int J Obes. 2009;33(7):743–52. PubMed PMID: 19528964. Pubmed Central PMCID: 2710391.

    Article  CAS  Google Scholar 

  16. Blair NJ, Thompson JM, Black PN, Becroft DM, Clark PM, Han DY, et al. Risk factors for obesity in 7-year-old European children: the Auckland Birthweight Collaborative Study. Arch Dis Child. 2007;92(10):866–71. PubMed PMID: 17855436. Pubmed Central PMCID: 2083229.

    Article  PubMed  Google Scholar 

  17. Burdette HL, Whitaker RC, Hall WC, Daniels SR. Maternal infant-feeding style and children’s adiposity at 5 years of age. Arch Pediatr Adolesc Med. 2006;160(5):513–20. PubMed PMID: 16651495.

    Article  PubMed  Google Scholar 

  18. Gale CR, Javaid MK, Robinson SM, Law CM, Godfrey KM, Cooper C. Maternal size in pregnancy and body composition in children. J Clin Endocrinol Metab. 2007;92(10):3904–11. PubMed PMID: 17684051. Pubmed Central PMCID: 2066182.

    Article  PubMed  CAS  Google Scholar 

  19. Crozier SR, Inskip HM, Godfrey KM, Cooper C, Harvey NC, Cole ZA, et al. Weight gain in pregnancy and childhood body composition: findings from the Southampton Women’s Survey. Am J Clin Nutr. 2010;91(6):1745–51. PubMed PMID: 20375187. Pubmed Central PMCID: 3091013.

    Article  PubMed  CAS  Google Scholar 

  20. Oken E, Taveras EM, Kleinman KP, Rich-Edwards JW, Gillman MW. Gestational weight gain and child adiposity at age 3 years. Am J Obstet Gynecol. 2007;196(4):322.e1–8. PubMed PMID: 17403405. Pubmed Central PMCID: 1899090.

    Article  Google Scholar 

  21. Olson CM, Strawderman MS, Dennison BA. Maternal weight gain during pregnancy and child weight at age 3 years. Matern Child Health J. 2009;13(6):839–46. PubMed PMID: 18818995.

    Article  PubMed  Google Scholar 

  22. Oken E, Rifas-Shiman SL, Field AE, Frazier AL, Gillman MW. Maternal gestational weight gain and offspring weight in adolescence. Obstet Gynecol. 2008;112(5):999–1006. PubMed PMID: 18978098. Pubmed Central PMCID: 3001295.

    Article  PubMed  Google Scholar 

  23. Reynolds RM. Excess maternal weight gain during pregnancy is associated with overweight/obesity in offspring at age 16 years, but maternal pre-pregnancy obesity has a greater effect. Evid Based Nurs. 2013;16(2):43–4. PubMed PMID: 23100266.

    Article  PubMed  Google Scholar 

  24. Mamun AA, O’Callaghan MJ, Williams GM, Najman JM. Change in maternal body mass index is associated with offspring body mass index: a 21-year prospective study. Eur J Nutr. 2013;52(6):1597–606. PubMed PMID: 23197072.

    Google Scholar 

  25. Reynolds RM, Osmond C, Phillips DI, Godfrey KM. Maternal BMI, parity, and pregnancy weight gain: influences on offspring adiposity in young adulthood. J Clin Endocrinol Metab. 2010;95(12):5365–9. PubMed PMID: 20702520.

    Article  PubMed  CAS  Google Scholar 

  26. Catalano PM, Drago NM, Amini SB. Maternal carbohydrate metabolism and its relationship to fetal growth and body composition. Am J Obstet Gynecol. 1995;172(5):1464–70. PubMed PMID: 7755055.

    Article  PubMed  CAS  Google Scholar 

  27. Koupil I, Toivanen P. Social and early-life determinants of overweight and obesity in 18-year-old Swedish men. Int J Obes. 2008;32(1):73–81. PubMed PMID: 17667914.

    Article  CAS  Google Scholar 

  28. Villamor E, Cnattingius S. Interpregnancy weight change and risk of adverse pregnancy outcomes: a population-based study. Lancet. 2006;368(9542):1164–70. PubMed PMID: 17011943.

    Article  PubMed  Google Scholar 

  29. Kral JG, Biron S, Simard S, Hould FS, Lebel S, Marceau S, et al. Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years. Pediatrics. 2006;118(6):e1644–9. PubMed PMID: 17142494.

    Article  PubMed  Google Scholar 

  30. Smith J, Cianflone K, Biron S, Hould FS, Lebel S, Marceau S, et al. Effects of maternal surgical weight loss in mothers on intergenerational transmission of obesity. J Clin Endocrinol Metab. 2009;94(11):4275–83. PubMed PMID: 19820018.

    Article  PubMed  CAS  Google Scholar 

  31. Filler G, Rayar MS, da Silva O, Buffo I, Pepelassis D, Sharma AP. Should prevention of chronic kidney disease start before pregnancy? Int Urol Nephrol. 2008;40(2):483–8. PubMed PMID: 18246441.

    Article  PubMed  Google Scholar 

  32. Lawlor DA, Najman JM, Sterne J, Williams GM, Ebrahim S, Davey Smith G. Associations of parental, birth, and early life characteristics with systolic blood pressure at 5 years of age: findings from the Mater-University study of pregnancy and its outcomes. Circulation. 2004;110(16):2417–23. PubMed PMID: 15477400.

    Article  PubMed  Google Scholar 

  33. Wen X, Triche EW, Hogan JW, Shenassa ED, Buka SL. Prenatal factors for childhood blood pressure mediated by intrauterine and/or childhood growth? Pediatrics. 2011;127(3):e713–21. PubMed PMID: 21300676. Pubmed Central PMCID: 3065147.

    Article  PubMed  Google Scholar 

  34. Laor A, Stevenson DK, Shemer J, Gale R, Seidman DS. Size at birth, maternal nutritional status in pregnancy, and blood pressure at age 17: population based analysis. BMJ. 1997;315(7106):449–53. PubMed PMID: 9284660. Pubmed Central PMCID: 2127333.

    Article  PubMed  CAS  Google Scholar 

  35. Hochner H, Friedlander Y, Calderon-Margalit R, Meiner V, Sagy Y, Avgil-Tsadok M, et al. Associations of maternal prepregnancy body mass index and gestational weight gain with adult offspring cardiometabolic risk factors: the Jerusalem Perinatal Family Follow-up Study. Circulation. 2012;125(11):1381–9. PubMed PMID: 22344037. Pubmed Central PMCID: 3332052.

    Article  PubMed  CAS  Google Scholar 

  36. Fraser A, Tilling K, Macdonald-Wallis C, Sattar N, Brion MJ, Benfield L, Ness A, Deanfield J, Hingorani A, Nelson SM, Smith GD, Lawlor DA. Association of maternal weight gain in pregnancy with offspring obesity and metabolic and vascular traits in childhood. Circulation. 2010;121(23):2557–64.

    Article  PubMed  Google Scholar 

  37. Mingrone G, Manco M, Mora ME, Guidone C, Iaconelli A, Gniuli D, et al. Influence of maternal obesity on insulin sensitivity and secretion in offspring. Diabetes Care. 2008;31(9):1872–6. PubMed PMID: 18535193. Pubmed Central PMCID: 2518362.

    Article  PubMed  Google Scholar 

  38. Catalano PM, Presley L, Minium J, Hauguel-de Mouzon S. Fetuses of obese mothers develop insulin resistance in utero. Diabetes Care. 2009;32(6):1076–80. PubMed PMID: 19460915. Pubmed Central PMCID: 2681036.

    Article  PubMed  CAS  Google Scholar 

  39. Ali Z, Ulrik CS. Obesity and asthma: a coincidence or a causal relationship? A systematic review. Respir Med. 2013;107(9):1287–300. PubMed PMID: 23642708.

    Google Scholar 

  40. Haberg SE, Stigum H, London SJ, Nystad W, Nafstad P. Maternal obesity in pregnancy and respiratory health in early childhood. Paediatr Perinat Epidemiol. 2009;23(4):352–62. PubMed PMID: 19523082. Pubmed Central PMCID: 2827878.

    Article  PubMed  Google Scholar 

  41. Harpsoe MC, Basit S, Bager P, Wohlfahrt J, Benn CS, Nohr EA, et al. Maternal obesity, gestational weight gain, and risk of asthma and atopic disease in offspring: a study within the Danish National Birth Cohort. J Allergy Clin Immunol. 2013;131(4):1033–40. PubMed PMID: 23122630.

    Article  PubMed  Google Scholar 

  42. Kumar R, Story RE, Pongracic JA, Hong X, Arguelles L, Wang G, et al. Maternal pre-pregnancy obesity and recurrent wheezing in early childhood. Pediatr Allergy Immunol Pulmonol. 2010;23(3):183–90. PubMed PMID: 22375278. Pubmed Central PMCID: 3281288.

    Article  PubMed  Google Scholar 

  43. Lowe A, Braback L, Ekeus C, Hjern A, Forsberg B. Maternal obesity during pregnancy as a risk for early-life asthma. J Allergy Clin Immunol. 2011;128(5):1107–9.e1-2. PubMed PMID: 21958587.

    Article  PubMed  Google Scholar 

  44. Patel SP, Rodriguez A, Little MP, Elliott P, Pekkanen J, Hartikainen AL, et al. Associations between pre-pregnancy obesity and asthma symptoms in adolescents. J Epidemiol Community Health. 2012;66(9):809–14. PubMed PMID: 21844604. Pubmed Central PMCID: 3412048.

    Article  PubMed  Google Scholar 

  45. Reichman NE, Nepomnyaschy L. Maternal pre-pregnancy obesity and diagnosis of asthma in offspring at age 3 years. Matern Child Health J. 2008;12(6):725–33. PubMed PMID: 17987372.

    Article  PubMed  Google Scholar 

  46. Scholtens S, Wijga AH, Brunekreef B, Kerkhof M, Postma DS, Oldenwening M, et al. Maternal overweight before pregnancy and asthma in offspring followed for 8 years. Int J Obes. 2010;34(4):606–13. PubMed PMID: 19786965.

    Article  CAS  Google Scholar 

  47. Stothard KJ, Tennant PW, Bell R, Rankin J. Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis. JAMA. 2009;301(6):636–50. PubMed PMID: 19211471.

    Article  PubMed  CAS  Google Scholar 

  48. Jones PB, Rantakallio P, Hartikainen AL, Isohanni M, Sipila P. Schizophrenia as a long-term outcome of pregnancy, delivery, and perinatal complications: a 28-year follow-up of the 1966 north Finland general population birth cohort. Am J Psychiatry. 1998;155(3):355–64. PubMed PMID: 9501745.

    PubMed  CAS  Google Scholar 

  49. Schaefer CA, Brown AS, Wyatt RJ, Kline J, Begg MD, Bresnahan MA, et al. Maternal prepregnant body mass and risk of schizophrenia in adult offspring. Schizophr Bull. 2000;26(2):275–86. PubMed PMID: 10885630.

    Article  PubMed  CAS  Google Scholar 

  50. Wahlbeck K, Forsen T, Osmond C, Barker DJ, Eriksson JG. Association of schizophrenia with low maternal body mass index, small size at birth, and thinness during childhood. Arch Gen Psychiatry. 2001;58(1):48–52. PubMed PMID: 11146757.

    Article  PubMed  CAS  Google Scholar 

  51. Kawai M, Minabe Y, Takagai S, Ogai M, Matsumoto H, Mori N, et al. Poor maternal care and high maternal body mass index in pregnancy as a risk factor for schizophrenia in offspring. Acta Psychiatr Scand. 2004;110(4):257–63. PubMed PMID: 15352926.

    Article  PubMed  CAS  Google Scholar 

  52. Krakowiak P, Walker CK, Bremer AA, Baker AS, Ozonoff S, Hansen RL, et al. Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders. Pediatrics. 2012;129(5):e1121–8. PubMed PMID: 22492772. Pubmed Central PMCID: 3340592.

    Article  PubMed  Google Scholar 

  53. Neggers YH, Goldenberg RL, Ramey SL, Cliver SP. Maternal prepregnancy body mass index and psychomotor development in children. Acta Obstet Gynecol Scand. 2003;82(3):235–40. PubMed PMID: 12694119.

    Article  PubMed  Google Scholar 

  54. Heikura U, Taanila A, Hartikainen AL, Olsen P, Linna SL, von Wendt L, Järvelin MR. Variations in prenatal sociodemographic factors associated with intellectual disability: a study of the 20-year interval between two birth cohorts in northern Finland. Am J Epidemiol. 2008;167(2):169–77. Epub 2007 Nov 17.

    Article  PubMed  Google Scholar 

  55. Rodriguez A, Miettunen J, Henriksen TB, Olsen J, Obel C, Taanila A, et al. Maternal adiposity prior to pregnancy is associated with ADHD symptoms in offspring: evidence from three prospective pregnancy cohorts. Int J Obes. 2008;32(3):550–7. PubMed PMID: 17938639.

    Article  CAS  Google Scholar 

  56. Rodriguez A. Maternal pre-pregnancy obesity and risk for inattention and negative emotionality in children. J Child Psychol Psychiatry. 2010;51(2):134–43. PubMed PMID: 19674195.

    Article  PubMed  Google Scholar 

  57. Fernandes C, Grayton H, Poston L, Samuelsson AM, Taylor PD, Collier DA, et al. Prenatal exposure to maternal obesity leads to hyperactivity in offspring. Mol Psychiatry. 2012;17(12):1159–60. PubMed PMID: 22158015.

    Article  PubMed  CAS  Google Scholar 

  58. Van Lieshout RJ, Taylor VH, Boyle MH. Pre-pregnancy and pregnancy obesity and neurodevelopmental outcomes in offspring: a systematic review. Obes Rev. 2011;12(5):e548–59. PubMed PMID: 21414129.

    Article  PubMed  Google Scholar 

  59. Allen KL, Byrne SM, Forbes D, Oddy WH. Risk factors for full- and partial-syndrome early adolescent eating disorders: a population-based pregnancy cohort study. J Am Acad Child Adolesc Psychiatry. 2009;48(8):800–9. PubMed PMID: 19564799.

    Article  PubMed  Google Scholar 

  60. Saha S, Chant D, Welham J, McGrath J. A systematic review of the prevalence of schizophrenia. PLoS Med. 2005;2(5):e141. PubMed PMID: 15916472. Pubmed Central PMCID: 1140952.

    Article  PubMed  Google Scholar 

  61. Messias EL, Chen CY, Eaton WW. Epidemiology of schizophrenia: review of findings and myths. Psychiatr Clin North Am. 2007;30(3):323–38. PubMed PMID: 17720026. Pubmed Central PMCID: 2727721.

    Article  PubMed  Google Scholar 

  62. Mura G, Petretto DR, Bhat KM, Carta MG. Schizophrenia: from epidemiology to rehabilitation. Clin Pract Epidemiol Ment Health. 2012;8:52–66. PubMed PMID: 22962559. Pubmed Central PMCID: 3434422.

    Article  PubMed  Google Scholar 

  63. Rifkin L, Lewis S, Jones P, Toone B, Murray R. Low birth weight and schizophrenia. Br J Psychiatry Suppl. 1994;165(3):357–62. PubMed PMID: 7994506.

    Article  CAS  Google Scholar 

  64. Abel KM, Wicks S, Susser ES, Dalman C, Pedersen MG, Mortensen PB, et al. Birth weight, schizophrenia, and adult mental disorder: is risk confined to the smallest babies? Arch Gen Psychiatry. 2010;67(9):923–30. PubMed PMID: 20819986.

    Article  PubMed  Google Scholar 

  65. Cannon M, Jones PB, Murray RM. Obstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiatry. 2002;159(7):1080–92. PubMed PMID: 12091183.

    Article  PubMed  Google Scholar 

  66. Moilanen K, Jokelainen J, Jones PB, Hartikainen AL, Jarvelin MR, Isohanni M. Deviant intrauterine growth and risk of schizophrenia: a 34-year follow-up of the Northern Finland 1966 Birth Cohort. Schizophr Res. 2010;124(1–3):223–30. PubMed PMID: 20933367.

    Article  PubMed  Google Scholar 

  67. Gunnell D, Rasmussen F, Fouskakis D, Tynelius P, Harrison G. Patterns of fetal and childhood growth and the development of psychosis in young males: a cohort study. Am J Epidemiol. 2003;158(4):291–300. PubMed PMID: 12915493.

    Article  PubMed  Google Scholar 

  68. Wegelius A, Tuulio-Henriksson A, Pankakoski M, Haukka J, Lehto U, Paunio T, et al. An association between high birth weight and schizophrenia in a Finnish schizophrenia family study sample. Psychiatry Res. 2011;190(2–3):181–6. PubMed PMID: 21664700.

    Article  PubMed  Google Scholar 

  69. Bersani G, Manuali G, Ramieri L, Taddei I, Bersani I, Conforti F, et al. The potential role of high or low birthweight as risk factor for adult schizophrenia. J Perinat Med. 2007;35(2):159–61. PubMed PMID: 17302511.

    Article  PubMed  Google Scholar 

  70. Hamlyn J, Duhig M, McGrath J, Scott J. Modifiable risk factors for schizophrenia and autism – shared risk factors impacting on brain development. Neurobiol Dis. 2013;53:3–9. PubMed PMID: 23123588.

    Article  PubMed  Google Scholar 

  71. Khandaker GM, Zimbron J, Lewis G, Jones PB. Prenatal maternal infection, neurodevelopment and adult schizophrenia: a systematic review of population-based studies. Psychol Med. 2013;43(2):239–57. PubMed PMID: 22717193. Pubmed Central PMCID: 3479084.

    Article  PubMed  CAS  Google Scholar 

  72. Khandaker GM, Dibben CR, Jones PB. Does maternal body mass index during pregnancy influence risk of schizophrenia in the adult offspring? Obes Rev. 2012;13(6):518–27. PubMed PMID: 22188548. Pubmed Central PMCID: 3492912.

    Article  PubMed  CAS  Google Scholar 

  73. Hauguel-de Mouzon S, Lepercq J, Catalano P. The known and unknown of leptin in pregnancy. Am J Obstet Gynecol. 2006;194(6):1537–45. PubMed PMID: 16731069.

    Article  PubMed  CAS  Google Scholar 

  74. Ashwood P, Kwong C, Hansen R, Hertz-Picciotto I, Croen L, Krakowiak P, et al. Brief report: plasma leptin levels are elevated in autism: association with early onset phenotype? J Autism Dev Disord. 2008;38(1):169–75. PubMed PMID: 17347881.

    Article  PubMed  Google Scholar 

  75. Onore C, Careaga M, Ashwood P. The role of immune dysfunction in the pathophysiology of autism. Brain Behav Immun. 2012;26(3):383–92. PubMed PMID: 21906670. Pubmed Central PMCID: 3418145.

    Article  PubMed  CAS  Google Scholar 

  76. Finer LB, Zolna MR. Unintended pregnancy in the United States: incidence and disparities, 2006. Contraception. 2011;84(5):478–85. PubMed PMID: 22018121. Pubmed Central PMCID: 3338192.

    Article  PubMed  Google Scholar 

  77. Rattanatray L, MacLaughlin SM, Kleemann DO, Walker SK, Muhlhausler BS, McMillen IC. Impact of maternal periconceptional overnutrition on fat mass and expression of adipogenic and lipogenic genes in visceral and subcutaneous fat depots in the postnatal lamb. Endocrinology. 2010;151(11):5195–205. PubMed PMID: 20861234.

    Article  PubMed  CAS  Google Scholar 

  78. Zambrano E, Martinez-Samayoa PM, Rodriguez-Gonzalez GL, Nathanielsz PW. Dietary intervention prior to pregnancy reverses metabolic programming in male offspring of obese rats. J Physiol. 2010;588(Pt 10):1791–9. PubMed PMID: 20351043. Pubmed Central PMCID: 2887995.

    Article  PubMed  CAS  Google Scholar 

  79. Gallou-Kabani C, Vige A, Gross MS, Boileau C, Rabes JP, Fruchart-Najib J, et al. Resistance to high-fat diet in the female progeny of obese mice fed a control diet during the periconceptual, gestation, and lactation periods. Am J Physiol Endocrinol Metab. 2007;292(4):E1095–100. PubMed PMID: 17164437.

    Article  PubMed  CAS  Google Scholar 

  80. Giraudo SQ, Della-Fera MA, Proctor L, Wickwire K, Ambati S, Baile CA. Maternal high fat feeding and gestational dietary restriction: effects on offspring body weight, food intake and hypothalamic gene expression over three generations in mice. Pharmacol Biochem Behav. 2010;97(1):121–9. PubMed PMID: 20430050.

    Article  PubMed  CAS  Google Scholar 

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Baptiste-Roberts, K. (2014). Maternal Obesity and Implications for the Long-Term Health of the Offspring. In: Nicholson, W., Baptiste-Roberts, K. (eds) Obesity During Pregnancy in Clinical Practice. Springer, London. https://doi.org/10.1007/978-1-4471-2831-1_11

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