Sinonasal cancer, the cancer of the nose and paranasal cavities is a rare type of cancer. Its incidence varies between men (0.5–1.5 new cases annually per 100,000) and women (0.1–0.6/100,000) and also from country to country. These variations in incidence are mostly explained by differences in occupational exposure, in particular exposure to wood dust, which is by far the major risk factor. This chapter gives an overview of studies on sinonasal cancer dealing with epidemiological findings and various occupational risk factors, exposure levels and other exposure characteristics, tumor pathology, the molecular cancer mechanisms likely to be involved in the development of the disease, and, finally, molecular alterations observed in tumors and available as potential molecular markers. The main studies and their findings as well as the principal pathological features of sinonasal tumors are summarized in tables and exemplified in illustrations.
- Sinonasal cancer
- Occupational factors
- Wood dust exposure
- Molecular markers
- Mechanisms of carcinogenesis
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We thank all our colleagues who participated in the research collaboration in connection with the EU 5 FW project WOODRISK (QLK-2000-00573) and afterwards. Dr. Ewen MacDonald, University of Eastern Finland, Kuopio, is thanked for language revision and Ms. Ritva Järnström, Finnish Institute of Occupational Health, Helsinki, for technical assistance.
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Husgafvel-Pursiainen, K. et al. (2014). Sinonasal Cancer. In: Anttila, S., Boffetta, P. (eds) Occupational Cancers. Springer, London. https://doi.org/10.1007/978-1-4471-2825-0_7
Publisher Name: Springer, London
Print ISBN: 978-1-4471-2824-3
Online ISBN: 978-1-4471-2825-0