Abstract
Many known and potential human carcinogens are related to workplace exposures. Primary prevention is the optimal prevention strategy for occupational cancer control through activities intended to eliminate harmful exposure(s) in the workplace. Secondary prevention provided by medical screening remains an important component of sound occupational health practice in many instances. One of the aims of secondary prevention is to reduce morbidity and mortality through detection of illness at an early stage when treatment may succeed in altering progression of disease. Medical screening data, ideally collected in a standardized manner, aggregated, and evaluated over time, can also be evaluated as a part of a surveillance program and play an important role in primary prevention.
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References
Boffetta P. Epidemiology of environmental and occupational cancer. Oncogene. 2004;23:6392–403.
Landrigan PJ. The prevention of occupational cancer. CA Cancer J Clin. 1996;46:67–9.
Siemiatycki J, Richardson L, Straif K, et al. Listing occupational carcinogens. Environ Health Perspect. 2004;112(15):1447–59.
Cone JE, Rosenberg J. Medical surveillance and biomonitoring for occupational cancer endpoints. Occup Med. 1990;5(3):563–81.
Ward E. Cancer. In: Levy BS, Wegman DH, Baron SL, Sokas RK, editors. Occupational and environmental health: recognizing and preventing disease and injury. 6th ed. Oxford: University Press; 2011. p. 366–97.
Bode AM, Dong Z. Cancer prevention research – then and now. Nat Rev Cancer. 2009;9(7):508–16.
Gochfeld M. Medical surveillance and screening in the workplace: complementary preventive strategies. Environ Res. 1992;59:67–80.
Silverstein MA. Medical screening, surveillance, and the prevention of occupational disease. J Occup Med. 1990;32(10):1032–6.
Baker E, Matte T. Occupational health surveillance. In: Rosenstock L, Cullen MR, Brodkin CA, Redlich CA, editors. Textbook of clinical occupational and environmental medicine. 2nd ed. Philadelphia: Elsevier Saunders Company; 2005. p. 76–82.
Halperin WE, Ratcliffe J, Frazier TM, Wilson L, Becker SP, Schulte PA. Medical screening in the workplace: proposed principles. J Occup Med. 1986;28(8):547–52.
Millar JD. Screening and monitoring: tools for prevention. J Occup Med. 1986;28(8):544–6.
Matte TD, Fine L, Meinhardt TJ, Baker EL. Guidelines for medical screening in the workplace. Occup Med. 1990;5(3):439–56.
Atkinson Jr AJ, Colburn WA, DeGruttola VG, et al. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001;69:89–95.
Schulte PA. Opportunities for the development and use of biomarkers. Toxicol Lett. 1995;77:25–9.
National Research Council Committee on Biological Markers. Biological markers in environmental health research. Environ Health Perspect. 1987;74:3–9.
Schulte PA. Problems in notification and screening of workers at high-risk of disease. J Occup Environ Med. 1986;28(10):951–7.
Schulte PA. The use of biomarkers in surveillance, medical screening, and intervention. Mutat Res Fundam Mol Mech Mutagen. 2005;592(1–2):155–63.
Gallo V, Khan A, Gonzales C, et al. Validation of biomarkers for the study of environmental carcinogens: a review. Biomarkers. 2008;13(5):505–34.
Vineis P, Perera F. Molecular epidemiology and biomarkers in etiologic cancer research: the new in light of the old. Cancer Epidemiol Biomarkers Prev. 2007;16(10):1954–65.
Swenberg JA, Fryar-Tita E, Jeong YC. Biomarkers in toxicology and risk assessment: informing critical dose-response relationships. Chem Res Toxicol. 2008;21(1):253–65.
Gyorffy E, Anna L, Kovács K, Rudnai P, Schoket B. Correlation between biomarkers of human exposure to genotoxins with focus on carcinogen-DNA adducts. Mutagenesis. 2008;23(1):1–18.
Valverde M, Rojas E. Environmental and occupational biomonitoring using the comet assay. Mutat Res Rev Mutat Res. 2009;681:93–109.
Christiani D, Mehta A, Yu CL. Genetic susceptibility to occupational exposures. Occup Environ Med. 2008;65:430–6.
Rueff J, Teixeirab JP, Santosa LS, Gaspara JF. Genetic effects and biotoxicity monitoring of occupational styrene exposure. Clin Chim Acta. 2009;399(1–2):8–23.
Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.
National Toxicology Program. Report on carcinogens. 12th ed. Research Triangle Park: U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program; 2011.
American Cancer Society Cancer Facts & Figures. 2010. http://www.cancer.org/acs/groups/content/@nho/documents/document/acspc-024113.pdf. Accessed 6 Jun 2011.
Straif K. The burden of occupational cancer. Occup Environ Med. 2008;65(12):787–8.
Rushton L, Hutchings S, Brown T. The burden of cancer at work: estimation as the first step to prevention. Occup Environ Med. 2008;65:789–800.
Viera AJ. Predisease: when does it make sense? Epidemiol Rev. 2011;33:122–34.
Smith RA, Cokkinides V, Brooks D, et al. Cancer screening in the United States, 2011: a review of current American Cancer Society guidelines and issues in cancer screening. CA Cancer J Clin. 2011;61(1):8–30.
Cancer prevention and control. http://www.cdc.gov/cancer/dcpc/prevention/screening.htm. Accessed 6 Jun 2011.
Recommendations for adults – cancer. http://www.uspreventiveservicestaskforce.org/adultrec.htm#cancer. Accessed 6 Jun 2011.
Smith RA, Mettlin CJ. Cancer detection. In: Lenhard Jr RE, Osteen RT, Gansler T, editors. Clinical oncology. Atlanta: American Cancer Society; 2001. p. 75–122.
Levin B, Prorok PC. Principles of screening. In: Schottenfeld D, Fraumeni JF, editors. Cancer epidemiology and prevention. Oxford: University Press; 2006. p. 1310–7.
Smith RA, Mettlin CJ, Davis KJ, Eyre H. American Cancer Society guidelines for the early detection of cancer. CA Cancer J Clin. 2000;50:34–49.
Schulte PA. Some implications of genetic biomarkers in occupational epidemiology and practice. Scand J Work Environ Health. 2004;30(1):71–9.
Samuels SW. Medical surveillance-biological, social, and ethical parameters. J Occup Environ Med. 1986;28(8):572–7.
Samuels SW. The Selikoff agenda and the human genome project: ethics and social issues. In: Samuels SW, Upton AC, editors. Genes, cancer, and ethics in the work environment. Beverly Farms: OEM Press; 1998. p. 3–9.
Screening and surveillance: a guide to OSHA standards. http://www.osha.gov/Publications/osha3162.pdf. Accessed 23 Jun 2011.
Herbert R, Szeinuk J. Integrating clinical care with prevention of occupational illness and injury. In: Rosenstock L, Cullen MR, Brodkin CA, Redlich CA, editors. Textbook of clinical occupational and environmental medicine. 2nd ed. Philadelphia: Elsevier Saunders Company; 2005. p. 1263–74.
Rutstein D, Mullan RJ, Frazier TM, et al. Sentinel health events (occupational): a basis for physician recognition and public health surveillance. Am J Public Health. 1983;73:1054–62.
Schulte PA, Ehrenberg RL, Singal M. Investigation of occupational cancer clusters: theory and practice. Am J Public Health. 1987;77(1):52–6.
Humphrey LL, Teutsch S, Johnson M. Lung cancer screening with sputum cytologic examination, chest radiography, and computed tomography: an update for the US Preventive Services Task Force. Ann Intern Med. 2004;140(9):740–53.
McCunney RJ. Should we screen for occupational lung cancer with low-dose computed tomography? J Occup Environ Med. 2006;48:1328–33.
Clin B, Morlais F, Guittet L, et al. Performance of chest radiograph and CT scan for lung cancer screening in asbestos-exposed workers. Occup Environ Med. 2009;66(8):529–34.
Statement concerning the national lung screening trial. http://www.cancer.gov/images/DSMB-NLST.pdf. Accessed July 2011.
The National Lung Screening Trial Research Team. Reduced lung-cancer mortality with low-dose computed tomographic screening. New Engl J Med. 2011;365(5):395–409.
Wood DE, Eapen GA, Ettinger DS, et al. Lung cancer screening. J Natl Compr Canc Netw. 2012;10:240–65.
American Lung Association. Providing guidance on lung cancer screening to patients and physicians. 2012. Available at http://www.lung.org/finding-cures/research-news/new-screening-guidelines/lung-cancer-screening.pdf. Accessed 7 Jun 2013.
Bach PB, Mirkin JN, Oliver TK, et al. Benefits and harms of CT screening for lung cancer: a systematic review. JAMA. 2012;307(22):2418–2429.
Jacobson FL, Austin JH, Field JK, et al. Development of The American Association for Thoracic Surgery guidelines for low-dose computed tomography scans to screen for lung cancer in North America: recommendations of The American Association for Thoracic Surgery Task Force for lung cancer screening and surveillance. J Thorac Cardiovasc Surg. 2012;144(1):25–32.
U.S. Preventive Services Task Force (USPSTF). Screening for lung cancer recommendation statement 2013. Available at http://www.uspreventiveservicestaskforce.org/uspstf13/lungcan/lungcanfinalrs.htm. Accessed 9 April 2014.
Mettler F, Huda W, Yoshizumi TT, Mahesh M. Effective doses in radiology and diagnostic nuclear medicine: a catalog. Radiology. 2008;248(1):254–63.
Brenner D. Radiation risks potentially associated with low-dose CT screening of adult smokers for lung cancer. Radiology. 2004;231(2):440–5.
Markowitz SB, Miller A, Miller J, et al. Ability of low-dose helical CT to distinguish between benign and malignant noncalcified lung nodules. Chest. 2007;131:1028–34.
Baldwin DR, Duffy SW, Wald NJ, et al. UK lung screen (UKLS) nodule management protocol: modelling of a single screen randomised controlled trial of low-dose CT screening for lung cancer. Thorax. 2011;66:308–13.
Tammemagi MC, Lam SC, McWilliams AM, et al. Incremental value of pulmonary function and sputum DNA image cytometry in lung cancer risk prediction. Cancer Prev Res. 2011;4(4):552–61.
Tammemagi MC, Pinsky PF, Caporaso NE, et al. Lung cancer risk prediction: prostate, lung, colorectal and ovarian cancer screening trial models and validation. J Natl Cancer Inst. 2011;103:1–11.
Vehmas T. Factors influencing the prevalence of pulmonary nodules in lung cancer screening trials: re-evaluation of a CT study. Ups J Med Sci. 2008;113(3):279–86.
Mazzone PJ. Lung cancer screening: an update, discussion, and look ahead. Curr Oncol Rep. 2010;12(4):226–34.
Pegna AL, Picozzi G. Lung cancer screening update. Curr Opin Pulm Med. 2009;15(4):327–33.
Twombly R. Lung cancer screening debate continues despite international CT study results. J Natl Cancer Inst. 2007;99(3):190–5.
Ruder AM, Carreon T, Ward EM, Schulte PA, Halperin W. Bladder cancer. In: Rosenstock L, Cullen MR, Brodkin CA, Redlich CA, editors. Textbook of clinical occupational and environmental medicine. 2nd ed. Philadelphia: Elsevier Saunders Company; 2005. p. 757–66.
Schulte PA. Screening for bladder cancer in high-risk groups – delineation of the problem. J Occup Environ Med. 1990;32(9):789–92.
Marsh GM, Leviton LC, Talbott EO, et al. Drake chemical workers health registry study – notification and medical surveillance of a group of workers at high-risk of developing bladder cancer. Am J Ind Med. 1991;19(3):291–301.
Chen HI, Liou SH, Loh CH, et al. Bladder cancer screening and monitoring of 4,4′-methylenebis(2-chloroaniline) exposure among workers in Taiwan. Urology. 2005;66(2):305–10.
Lotan Y, Roehrborn CG. Sensitivity and specificity of commonly available bladder tumor markers versus cytology: results of a comprehensive literature review and meta-analyses. Urology. 2003;61(1):109–18.
Fradet Y. Screening for bladder cancer: the best opportunity to reduce mortality. Can Urol Assoc J. 2009;3(6 Suppl 4):S180–3.
Katz MH, Steinberg GD. Editorial comment – bladder cancer screening in a high risk asymptomatic population using a point of care urine based protein tumor marker. J Urol. 2009;182(1):58.
Carreon T, Ruder AM, Schulte PA, et al. NAT2 slow acetylation and bladder cancer in workers exposed to benzidine. Int J Cancer. 2006;118(1):161–8.
Wang YH, Yeh SD, Shen KH, et al. A significantly joint effect between arsenic and occupational exposures and risk genotypes/diplotypes of CYP2E1, GSTO1 and GSTO2 on risk of urothelial carcinoma. Toxicol Appl Pharmacol. 2009;241(1):111–8.
Lotan Y, Elias K, Svatek RS, et al. Bladder cancer screening in a high risk asymptomatic population using a point of care urine based protein tumor marker. J Urol. 2009;182(1):52–7.
Chou R, Dana T. Screening adults for bladder cancer: a review of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2010;153(7):461–8.
Skin cancer facts. http://www.cancer.org/Cancer/CancerCauses/SunandUVExposure/skin-cancer-facts. Accessed 13 Jun 2011.
Silva JH, de Sa’ BC, de A’vila ALR, et al. Atypical mole syndrome and dysplastic nevi: identification of populations at risk for developing melanoma – review article. Clinics. 2011;66(3):493–9.
Kasparian NA, McLoone JK, Meiser B. Skin cancer-related prevention and screening behaviors: a review of the literature. J Behav Med. 2009;32(5):406–28.
Osborne JE. Skin cancer screening and surveillance. Br J Dermatol. 2002;146(5):745–54.
Lin JS, Eder M, Weinmann S. Behavioral counseling to prevent skin cancer: a systematic review for the U.S. Preventive Services Task Force. Ann Intern Med. 2011;154(3):190–201.
Cohen DE, Bassiri S, Forrester BG, Nethercott J. Skin cancers. In: Rosenstock L, Cullen MR, Brodkin CA, Redlich CA, editors. Textbook of clinical occupational and environmental medicine. 2nd ed. Philadelphia: Elsevier Saunders Company; 2005. p. 811–24.
Goldberg MS, Doucette JT, Lim HW, et al. Risk factors for presumptive melanoma in skin cancer screening: American Academy of Dermatology National Melanoma/Skin Cancer Screening Program experience 2001–2005. J Am Acad Dermatol. 2007;57(1):60–6.
Markovic SN, Erickson LA, Rao RD, et al. Malignant melanoma in the 21st century, part 1: epidemiology, risk factors, screening, prevention, and diagnosis. Mayo Clin Proc. 2007;82(3):364–80.
Wolff T, Tai E, Miller T. Screening for skin cancer: an update of the evidence for the U. S. Preventive Services Task Force. Ann Intern Med. 2009;150(3):194–8.
Swetter SM, Waddell BL, Vazquez MD, Khosravi VS. Increased effectiveness of targeted skin cancer screening in the Veterans Affairs population of Northern California. Prev Med. 2003;36(2):164–71.
Schmitt J, Seidler A, Diegpen TL, Bauer A. Occupational ultraviolet light exposure increases the risk for the development of cutaneous squamous cell carcinoma: a systematic review and meta-analysis. Br J Dermatol. 2011;164(2):291–307.
Kipen HM, Wartenberg D. Lymphohematopoietic malignancies. In: Rosenstock L, Cullen MR, Brodkin CA, Redlich CA, editors. Textbook of clinical occupational and environmental medicine. 2nd ed. Philadelphia: Elsevier Saunders Company; 2005. p. 744–56.
McDevitt MA, Condon M, Stamberg J, Karpa JE, McDiarmid M. Fluorescent in situ hybridization (FISH) in bone marrow and peripheral blood of leukemia patients: implications for occupational surveillance. Mutat Res Genet Toxicol Environ Mutagen. 2007;629(1):24–31.
Zhang LP, Lan Q, Guo W, et al. Chromosome-Wide Aneuploidy Study (CWAS) in workers exposed to an established leukemogen, benzene. Carcinogenesis. 2011;32(4):605–12.
Zhang LP, Tang X, Rothman N, et al. Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells. Cancer Epidemiol Biomarkers Prev. 2010;19(1):80–8.
Park EK, Sandrini A, Yates DH, et al. Soluble mesothelin-related protein in an asbestos-exposed population – the dust diseases board cohort study. Am J Respir Crit Care Med. 2008;178(8):832–7.
van Meerbeeck JP, Hillerdal G. Screening for mesothelioma – more harm than good? Am J Respir Crit Care Med. 2008;178(8):781–2.
Pass HI, Carobone M. Current status of screening for malignant pleural mesothelioma. Thorac Cardiovasc Surg. 2009;21:97–104.
U.S. Preventive Services Task Force. Screening for cervical cancer topic page. www.uspreventiveservicestaskforce.org/uspstf/uspscerv.htm. Accessed 6 May 2013.
U.S. Preventive Services Task Force. Screening for colorectal cancer topic page. www.uspreventiveservicestaskforce.org/uspstf/uspscolo.htm. Accessed 6 May 2013.
U.S. Preventive Services Task Force. Screening for breast cancer topic page. www.uspreventiveservicestaskforce.org/uspstf/uspsbrca.htm. Accessed 6 May 2013.
Driscoll T, Nelson DI, Steenland K, et al. The global burden of disease due to occupational carcinogens. Am J Ind Med. 2005;48:419–31.
Stevens RG, Hansen J, Costa G, et al. Considerations of circadian impact for defining ‘shift work’ in cancer studies: IARC Working Group Report. Occup Environ Med. 2011;68:154–62.
Clin B, Morlais F, Launoy G, et al. Cancer incidence within a cohort occupationally exposed to asbestos: a study of dose response relationships. Occup Environ Med. 2011;68:832–6.
Smith RA, Brooks D, Cokkinides V, et al. Cancer screening in the United States, 2013: a review of current American Cancer Society guidelines, current issues in cancer screening, and new guidance on cervical cancer screening and lung cancer screening. CA Cancer J Clin. 2013;63(2):87–105.
Breysse PN, Weaver V, Cadorette M, et al. Development of a medical examination program for former workers at a Department of Energy National Laboratory. Am J Ind Med. 2002;42(5):443–54.
Moline JM, Herbert R, Levin S, et al. WTC medical monitoring and treatment program: comprehensive health care response in aftermath of disaster. Mt Sinai J Med. 2008;75(2):67–75.
Moline JM, Herbert R, Crowley L, et al. Multiple myeloma in World Trade Center responders: a case series. J Occup Environ Med. 2009;51(8):896–902.
Trout DB, Schulte PA. Medical surveillance, exposure registries, and epidemiologic research for workers exposed to nanomaterials. Toxicology. 2010;269(2–3):128–35.
Nasterlack M, Zober A, Oberlinner C. Considerations on occupational medical surveillance in employees handling nanoparticles. Int Arch Occup Environ Health. 2008;81(6):721–6.
Fischman M, Storey E, McCunney RJ, Kosnett M. National Institute for Occupational Safety and Health nanomaterials and worker health conference – medical surveillance session summary report. J Occup Environ Med. 2011;53(6 Suppl):S35–7.
Schulte PA, Trout DB. Nanomaterials and worker health: medical surveillance, exposure registries, and epidemiologic research. J Occup Environ Med. 2011;53(6 Suppl):S3–7.
Nasterlack M. Role of medical surveillance in risk management. J Occup Environ Med. 2011;53(6 Suppl):S18–21.
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The authors thank Eileen Storey, Lynne Pinkerton, and Ellen Galloway for assistance in creating this chapter.
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Trout, D.B., Schulte, P.A., Tramma, S.L. (2014). Screening for Occupational Cancer. In: Anttila, S., Boffetta, P. (eds) Occupational Cancers. Springer, London. https://doi.org/10.1007/978-1-4471-2825-0_32
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