Malignant Tumors of the Male Reproductive System

Chapter

Abstract

The two main cancers of the male reproductive system are prostate cancer and testicular cancer, which have completely different epidemiological behaviors. Prostate cancer is one of the most common cancers in men, with an incidence strongly related with age, making it a cancer that mainly affects older men. Conversely, testicular cancer is quite rare and generally affects young men, with an incidence peak at age 35 years.

Keywords

Testicular cancer Prostate cancer Occupation Pesticides Firefighting 

References

  1. 1.
    Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127:2893–917.Google Scholar
  2. 2.
    Jones GW, Mettlin C, Murphy GP, Guinan P, Herr HW, Hussey DH, Chmiel JS, Fremgen AM, Clive RE, Zuber-Ocwieja KE, et al. Patterns of care for carcinoma of the prostate gland: results of a national survey of 1984 and 1990. J Am Coll Surg. 1995;180:545–54.PubMedGoogle Scholar
  3. 3.
    Gronberg H. Prostate cancer epidemiology. Lancet. 2003;361:859–64.PubMedGoogle Scholar
  4. 4.
    Rowlands MA, Gunnell D, Harris R, Vatten LJ, Holly JM, Martin RM. Circulating insulin-like growth factor peptides and prostate cancer risk: a systematic review and meta-analysis. Int J Cancer. 2009;124:2416–29.PubMedCentralPubMedGoogle Scholar
  5. 5.
    World Cancer Research Fund, American Institute for Cancer Research. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Washington, DC: AICR; 2007.Google Scholar
  6. 6.
    Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A, Hemminki K. Environmental and heritable factors in the causation of cancer – analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med. 2000;343:78–85.PubMedGoogle Scholar
  7. 7.
    Duggan D, Zheng SL, Knowlton M, Benitez D, Dimitrov L, Wiklund F, Robbins C, Isaacs SD, Cheng Y, Li G, Sun J, Chang BL, Marovich L, Wiley KE, Balter K, Stattin P, Adami HO, Gielzak M, Yan G, Sauvageot J, Liu W, Kim JW, Bleecker ER, Meyers DA, Trock BJ, Partin AW, Walsh PC, Isaacs WB, Gronberg H, Xu J, Carpten JD. Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP. J Natl Cancer Inst. 2007;99:1836–44.PubMedGoogle Scholar
  8. 8.
    Gudmundsson J, Sulem P, Steinthorsdottir V, Bergthorsson JT, Thorleifsson G, Manolescu A, Rafnar T, Gudbjartsson D, Agnarsson BA, Baker A, Sigurdsson A, Benediktsdottir KR, Jakobsdottir M, Blondal T, Stacey SN, Helgason A, Gunnarsdottir S, Olafsdottir A, Kristinsson KT, Birgisdottir B, Ghosh S, Thorlacius S, Magnusdottir D, Stefansdottir G, Kristjansson K, Bagger Y, Wilensky RL, Reilly MP, Morris AD, Kimber CH, Adeyemo A, Chen Y, Zhou J, So WY, Tong PC, Ng MC, Hansen T, Andersen G, Borch-Johnsen K, Jorgensen T, Tres A, Fuertes F, Ruiz-Echarri M, Asin L, Saez B, van Boven E, Klaver S, Swinkels DW, Aben KK, Graif T, Cashy J, Suarez BK, van Vierssen TO, Frigge ML, Ober C, Hofker MH, Wijmenga C, Christiansen C, Rader DJ, Palmer CN, Rotimi C, Chan JC, Pedersen O, Sigurdsson G, Benediktsson R, Jonsson E, Einarsson GV, Mayordomo JI, Catalona WJ, Kiemeney LA, Barkardottir RB, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet. 2007;39:977–83.PubMedGoogle Scholar
  9. 9.
    Murabito JM, Rosenberg CL, Finger D, Kreger BE, Levy D, Splansky GL, Antman K, Hwang SJ. A genome-wide association study of breast and prostate cancer in the NHLBI’s Framingham heart Study. BMC Med Genet. 2007;8 Suppl 1:S6.PubMedCentralPubMedGoogle Scholar
  10. 10.
    Yeager M, Orr N, Hayes RB, Jacobs KB, Kraft P, Wacholder S, Minichiello MJ, Fearnhead P, Yu K, Chatterjee N, Wang Z, Welch R, Staats BJ, Calle EE, Feigelson HS, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cancel-Tassin G, Cussenot O, Valeri A, Andriole GL, Gelmann EP, Tucker M, Gerhard DS, Fraumeni Jr JF, Hoover R, Hunter DJ, Chanock SJ, Thomas G. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet. 2007;39:645–9.PubMedGoogle Scholar
  11. 11.
    Eeles RA, Kote-Jarai Z, Giles GG, Olama AA, Guy M, Jugurnauth SK, Mulholland S, Leongamornlert DA, Edwards SM, Morrison J, Field HI, Southey MC, Severi G, Donovan JL, Hamdy FC, Dearnaley DP, Muir KR, Smith C, Bagnato M, Ardern-Jones AT, Hall AL, O’Brien LT, Gehr-Swain BN, Wilkinson RA, Cox A, Lewis S, Brown PM, Jhavar SG, Tymrakiewicz M, Lophatananon A, Bryant SL, Horwich A, Huddart RA, Khoo VS, Parker CC, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Fisher C, Jamieson C, Cooper CS, English DR, Hopper JL, Neal DE, Easton DF. Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet. 2008;40:316–21.PubMedGoogle Scholar
  12. 12.
    Gudmundsson J, Sulem P, Rafnar T, Bergthorsson JT, Manolescu A, Gudbjartsson D, Agnarsson BA, Sigurdsson A, Benediktsdottir KR, Blondal T, Jakobsdottir M, Stacey SN, Kostic J, Kristinsson KT, Birgisdottir B, Ghosh S, Magnusdottir DN, Thorlacius S, Thorleifsson G, Zheng SL, Sun J, Chang BL, Elmore JB, Breyer JP, McReynolds KM, Bradley KM, Yaspan BL, Wiklund F, Stattin P, Lindstrom S, Adami HO, McDonnell SK, Schaid DJ, Cunningham JM, Wang L, Cerhan JR, St Sauver JL, Isaacs SD, Wiley KE, Partin AW, Walsh PC, Polo S, Ruiz-Echarri M, Navarrete S, Fuertes F, Saez B, Godino J, Weijerman PC, Swinkels DW, Aben KK, Witjes JA, Suarez BK, Helfand BT, Frigge ML, Kristjansson K, Ober C, Jonsson E, Einarsson GV, Xu J, Gronberg H, Smith JR, Thibodeau SN, Isaacs WB, Catalona WJ, Mayordomo JI, Kiemeney LA, Barkardottir RB, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nat Genet. 2008;40:281–3.PubMedCentralPubMedGoogle Scholar
  13. 13.
    Thomas G, Jacobs KB, Yeager M, Kraft P, Wacholder S, Orr N, Yu K, Chatterjee N, Welch R, Hutchinson A, Crenshaw A, Cancel-Tassin G, Staats BJ, Wang Z, Gonzalez-Bosquet J, Fang J, Deng X, Berndt SI, Calle EE, Feigelson HS, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cussenot O, Valeri A, Andriole GL, Crawford ED, Tucker M, Gerhard DS, Fraumeni Jr JF, Hoover R, Hayes RB, Hunter DJ, Chanock SJ. Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet. 2008;40:310–5.PubMedGoogle Scholar
  14. 14.
    Eeles RA, Kote-Jarai Z, Al Olama AA, Giles GG, Guy M, Severi G, Muir K, Hopper JL, Henderson BE, Haiman CA, Schleutker J, Hamdy FC, Neal DE, Donovan JL, Stanford JL, Ostrander EA, Ingles SA, John EM, Thibodeau SN, Schaid D, Park JY, Spurdle A, Clements J, Dickinson JL, Maier C, Vogel W, Dork T, Rebbeck TR, Cooney KA, Cannon-Albright L, Chappuis PO, Hutter P, Zeegers M, Kaneva R, Zhang HW, Lu YJ, Foulkes WD, English DR, Leongamornlert DA, Tymrakiewicz M, Morrison J, Ardern-Jones AT, Hall AL, O’Brien LT, Wilkinson RA, Saunders EJ, Page EC, Sawyer EJ, Edwards SM, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Cooper CS, Southey MC, Lophatananon A, Liu JF, Kolonel LN, Le Marchand L, Wahlfors T, Tammela TL, Auvinen A, Lewis SJ, Cox A, FitzGerald LM, Koopmeiners JS, Karyadi DM, Kwon EM, Stern MC, Corral R, Joshi AD, Shahabi A, McDonnell SK, Sellers TA, Pow-Sang J, Chambers S, Aitken J, Gardiner RA, Batra J, Kedda MA, Lose F, Polanowski A, Patterson B, Serth J, Meyer A, Luedeke M, Stefflova K, Ray AM, Lange EM, Farnham J, Khan H, Slavov C, Mitkova A, Cao G, Easton DF. Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet. 2009;41:1116–21.PubMedCentralPubMedGoogle Scholar
  15. 15.
    Gudmundsson J, Sulem P, Gudbjartsson DF, Blondal T, Gylfason A, Agnarsson BA, Benediktsdottir KR, Magnusdottir DN, Orlygsdottir G, Jakobsdottir M, Stacey SN, Sigurdsson A, Wahlfors T, Tammela T, Breyer JP, McReynolds KM, Bradley KM, Saez B, Godino J, Navarrete S, Fuertes F, Murillo L, Polo E, Aben KK, van Oort IM, Suarez BK, Helfand BT, Kan D, Zanon C, Frigge ML, Kristjansson K, Gulcher JR, Einarsson GV, Jonsson E, Catalona WJ, Mayordomo JI, Kiemeney LA, Smith JR, Schleutker J, Barkardottir RB, Kong A, Thorsteinsdottir U, Rafnar T, Stefansson K. Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Nat Genet. 2009;41:1122–6.PubMedCentralPubMedGoogle Scholar
  16. 16.
    Ishak MB, Giri VN. A systematic review of replication studies of prostate cancer susceptibility genetic variants in high-risk men originally identified from genome-wide association studies. Cancer Epidemiol Biomarkers Prev. 2011;20:1599–610.PubMedGoogle Scholar
  17. 17.
    Armstrong B, Doll R. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer. 1975;15:617–31.PubMedGoogle Scholar
  18. 18.
    Shimizu H, Ross RK, Bernstein L, Yatani R, Henderson BE, Mack TM. Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County. Br J Cancer. 1991;63:963–6.PubMedCentralPubMedGoogle Scholar
  19. 19.
    Luo W, Birkett NJ, Ugnat AM, Mao Y. Cancer incidence patterns among Chinese immigrant populations in Alberta. J Immigr Health. 2004;6:41–8.PubMedGoogle Scholar
  20. 20.
    Zuccolo L, Harris R, Gunnell D, Oliver S, Lane JA, Davis M, Donovan J, Neal D, Hamdy F, Beynon R, Savovic J, Martin RM. Height and prostate cancer risk: a large nested case-control study (ProtecT) and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2008;17:2325–36.PubMedCentralPubMedGoogle Scholar
  21. 21.
    IARC. IARC monograph on the evaluation of the carcinogenic risk of chemicals to humans, Tobacco smoke and involuntary smoking, vol. 83. Lyon: IARC Press; 2004.Google Scholar
  22. 22.
    Gilbert R, Martin RM, Beynon R, Harris R, Savovic J, Zuccolo L, Bekkering GE, Fraser WD, Sterne JA, Metcalfe C. Associations of circulating and dietary vitamin D with prostate cancer risk: a systematic review and dose-response meta-analysis. Cancer Causes Control. 2011;22:319–40.PubMedGoogle Scholar
  23. 23.
    Gilbert R, Metcalfe C, Oliver SE, Whiteman DC, Bain C, Ness A, Donovan J, Hamdy F, Neal DE, Lane JA, Martin RM. Life course sun exposure and risk of prostate cancer: population-based nested case-control study and meta-analysis. Int J Cancer. 2009;125:1414–23.PubMedCentralPubMedGoogle Scholar
  24. 24.
    Chen L, Davey Smith G, Evans DM, Cox A, Lawlor DA, Donovan J, Yuan W, Day IN, Martin RM, Lane A, Rodriguez S, Davis M, Zuccolo L, Collin SM, Hamdy F, Neal D, Lewis SJ. Genetic variants in the vitamin d receptor are associated with advanced prostate cancer at diagnosis: findings from the prostate testing for cancer and treatment study and a systematic review. Cancer Epidemiol Biomarkers Prev. 2009;18:2874–81.PubMedGoogle Scholar
  25. 25.
    Gong Z, Neuhouser ML, Goodman PJ, Albanes D, Chi C, Hsing AW, Lippman SM, Platz EA, Pollak MN, Thompson IM, Kristal AR. Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial. Cancer Epidemiol Biomarkers Prev. 2006;15:1977–83.PubMedGoogle Scholar
  26. 26.
    Freedland SJ, Platz EA. Obesity and prostate cancer: making sense out of apparently conflicting data. Epidemiol Rev. 2007;29:88–97.PubMedGoogle Scholar
  27. 27.
    Platz EA, Till C, Goodman PJ, Parnes HL, Figg WD, Albanes D, Neuhouser ML, Klein EA, Thompson Jr IM, Kristal AR. Men with low serum cholesterol have a lower risk of high-grade prostate cancer in the placebo arm of the prostate cancer prevention trial. Cancer Epidemiol Biomarkers Prev. 2009;18:2807–13.PubMedCentralPubMedGoogle Scholar
  28. 28.
    Martin RM, Vatten L, Gunnell D, Romundstad P. Blood pressure and risk of prostate cancer: Cohort Norway (CONOR). Cancer Causes Control. 2010;21:463–72.PubMedGoogle Scholar
  29. 29.
    Thompson IM, Goodman PJ, Tangen CM, Lucia MS, Miller GJ, Ford LG, Lieber MM, Cespedes RD, Atkins JN, Lippman SM, Carlin SM, Ryan A, Szczepanek CM, Crowley JJ, Coltman Jr CA. The influence of finasteride on the development of prostate cancer. N Engl J Med. 2003;349:215–24.PubMedGoogle Scholar
  30. 30.
    Bonovas S, Filioussi K, Tsantes A. Diabetes mellitus and risk of prostate cancer: a meta-analysis. Diabetologia. 2004;47:1071–8.PubMedGoogle Scholar
  31. 31.
    Kasper JS, Giovannucci E. A meta-analysis of diabetes mellitus and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2006;15:2056–62.PubMedGoogle Scholar
  32. 32.
    Siemiatycki J, Richardson L, Straif K, Latreille B, Lakhani R, Campbell S, Rousseau MC, Boffetta P. Listing occupational carcinogens. Environ Health Perspect. 2004;112:1447–59.PubMedCentralPubMedGoogle Scholar
  33. 33.
    Pukkala E, Martinsen JI, Lynge E, Gunnarsdottir HK, Sparen P, Tryggvadottir L, Weiderpass E, Kjaerheim K. Occupation and cancer – follow-up of 15 million people in five Nordic countries. Acta Oncol. 2009;48:646–790.PubMedGoogle Scholar
  34. 34.
    Pearce NE, Sheppard RA, Fraser J. Case-control study of occupation and cancer of the prostate in New Zealand. J Epidemiol Community Health. 1987;41:130–2.PubMedCentralPubMedGoogle Scholar
  35. 35.
    Brownson RC, Chang JC, Davis JR, Bagby Jr JR. Occupational risk of prostate cancer: a cancer registry-based study. J Occup Med. 1988;30:523–6.PubMedGoogle Scholar
  36. 36.
    Elghany NA, Schumacher MC, Slattery ML, West DW, Lee JS. Occupation, cadmium exposure, and prostate cancer. Epidemiology. 1990;1:107–15.PubMedGoogle Scholar
  37. 37.
    Hsing AW, McLaughlin JK, Zheng W, Gao YT, Blot WJ. Occupation, physical activity, and risk of prostate cancer in Shanghai, People’s Republic of China. Cancer Causes Control. 1994;5:136–40.PubMedGoogle Scholar
  38. 38.
    van der Gulden JW, Kolk JJ, Verbeek AL. Work environment and prostate cancer risk. Prostate. 1995;27:250–7.PubMedGoogle Scholar
  39. 39.
    Aronson KJ, Siemiatycki J, Dewar R, Gerin M. Occupational risk factors for prostate cancer: results from a case-control study in Montreal, Quebec, Canada. Am J Epidemiol. 1996;143:363–73.PubMedGoogle Scholar
  40. 40.
    Boffetta P, Kogevinas M, Westerholm P, Saracci R. Exposure to occupational carcinogens and social class differences in cancer occurrence. IARC Sci Publ. 1997 (138); 331–41.Google Scholar
  41. 41.
    Krstev S, Baris D, Stewart P, Dosemeci M, Swanson GM, Greenberg RS, Schoenberg JB, Schwartz AG, Liff JM, Hayes RB. Occupational risk factors and prostate cancer in U.S. blacks and whites. Am J Ind Med. 1998;34:421–30.PubMedGoogle Scholar
  42. 42.
    Seidler A, Heiskel H, Bickeboller R, Elsner G. Association between diesel exposure at work and prostate cancer. Scand J Work Environ Health. 1998;24:486–94.PubMedGoogle Scholar
  43. 43.
    Band PR, Le ND, Fang R, Threlfall WJ, Gallagher RP. Identification of occupational cancer risks in British Columbia. Part II: a population-based case-control study of 1516 Prostatic cancer cases. J Occup Environ Med. 1999;41:233–47.PubMedGoogle Scholar
  44. 44.
    Charles LE, Loomis D, Shy CM, Newman B, Millikan R, Nylander-French LA, Couper D. Electromagnetic fields, polychlorinated biphenyls, and prostate cancer mortality in electric utility workers. Am J Epidemiol. 2003;157:683–91.PubMedGoogle Scholar
  45. 45.
    Zeegers MP, Friesema IH, Goldbohm RA, van den Brandt PA. A prospective study of occupation and prostate cancer risk. J Occup Environ Med. 2004;46:271–9.PubMedGoogle Scholar
  46. 46.
    Boers D, Zeegers MP, Swaen GM, Kant I, van den Brandt PA. The influence of occupational exposure to pesticides, polycyclic aromatic hydrocarbons, diesel exhaust, metal dust, metal fumes, and mineral oil on prostate cancer: a prospective cohort study. Occup Environ Med. 2005;62:531–7.PubMedCentralPubMedGoogle Scholar
  47. 47.
    Fritschi L, Glass DC, Tabrizi JS, Leavy JE, Ambrosini GL. Occupational risk factors for prostate cancer and benign prostatic hyperplasia: a case-control study in Western Australia. Occup Environ Med. 2007;64:60–5.PubMedCentralPubMedGoogle Scholar
  48. 48.
    Sass-Kortsak AM, Purdham JT, Kreiger N, Darlington G, Lightfoot NE. Occupational risk factors for prostate cancer. Am J Ind Med. 2007;50:568–76.PubMedGoogle Scholar
  49. 49.
    Ramanakumar AV, Nadon L, Siemiatycki J. Exposures in painting related occupations and risk of selected cancers: results from a case-control study in Montreal. Am J Ind Med. 2008;51:419–27.PubMedGoogle Scholar
  50. 50.
    IARC. Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures, vol. 92. Lyon: IARC; 2010.Google Scholar
  51. 51.
    van der Gulden JW. Metal workers and repairmen at risk for prostate cancer: a review. Prostate. 1997;30:107–16.PubMedGoogle Scholar
  52. 52.
    Stewart RE, Dennis LK, Dawson DV, Resnick MI. A meta-analysis of risk estimates for prostate cancer related to tire and rubber manufacturing operations. J Occup Environ Med. 1999;41:1079–84.PubMedGoogle Scholar
  53. 53.
    Alder N, Fenty J, Warren F, Sutton AJ, Rushton L, Jones DR, Abrams KR. Meta-analysis of mortality and cancer incidence among workers in the synthetic rubber-producing industry. Am J Epidemiol. 2006;164:405–20.PubMedGoogle Scholar
  54. 54.
    Girschik J, Glass D, Ambrosini GL, Fritschi L. Could mining be protective against prostate cancer? A study and literature review. Occup Environ Med. 2010;67:365–74.PubMedGoogle Scholar
  55. 55.
    Young E, Kreiger N, Purdham J, Sass-Kortsak A. Prostate cancer and driving occupations: could whole body vibration play a role? Int Arch Occup Environ Health. 2009;82:551–6.PubMedGoogle Scholar
  56. 56.
    IARC. IARC monograph on the evaluation of the carcinogenic risk of chemicals to humans, 98, vol. Painting, firefighting, and shiftwork. Lyon: IARC; 2010.Google Scholar
  57. 57.
    Ballard T, Lagorio S, De Angelis G, Verdecchia A. Cancer incidence and mortality among flight personnel: a meta-analysis. Aviat Space Environ Med. 2000;71:216–24.PubMedGoogle Scholar
  58. 58.
    Pukkala E, Aspholm R, Auvinen A, Eliasch H, Gundestrup M, Haldorsen T, Hammar N, Hrafnkelsson J, Kyyronen P, Linnersjo A, Rafnsson V, Storm H, Tveten U. Incidence of cancer among Nordic airline pilots over five decades: occupational cohort study. BMJ. 2002;325:567.PubMedCentralPubMedGoogle Scholar
  59. 59.
    Blettner M, Zeeb H, Auvinen A, Ballard TJ, Caldora M, Eliasch H, Gundestrup M, Haldorsen T, Hammar N, Hammer GP, Irvine D, Langner I, Paridou A, Pukkala E, Rafnsson V, Storm H, Tulinius H, Tveten U, Tzonou A. Mortality from cancer and other causes among male airline cockpit crew in Europe. Int J Cancer. 2003;106:946–52.PubMedGoogle Scholar
  60. 60.
    Potts CL. Cadmium proteinuria – the health of battery workers exposed to cadmium oxide dust. Ann Occup Hyg. 1965;8:55–61.PubMedGoogle Scholar
  61. 61.
    Feustel A, Wennrich R, Steiniger D, Klauss P. Zinc and cadmium concentration in prostatic carcinoma of different histological grading in comparison to normal prostate tissue and adenofibromyomatosis (BPH). Urol Res. 1982;10:301–3.PubMedGoogle Scholar
  62. 62.
    Ogunlewe JO, Osegbe DN. Zinc and cadmium concentrations in indigenous blacks with normal, hypertrophic, and malignant prostate. Cancer. 1989;63:1388–92.PubMedGoogle Scholar
  63. 63.
    Brys M, Nawrocka AD, Miekos E, Zydek C, Foksinski M, Barecki A, Krajewska WM. Zinc and cadmium analysis in human prostate neoplasms. Biol Trace Elem Res. 1997;59:145–52.PubMedGoogle Scholar
  64. 64.
    Waalkes MP. Cadmium carcinogenesis. Mutat Res. 2003;533:107–20.PubMedGoogle Scholar
  65. 65.
    IARC. Beryllium, cadmium, mercury, and exposures in the glass manufacturing industry, vol. 58. Lyon: IARC; 1993.Google Scholar
  66. 66.
    Sahmoun AE, Case LD, Jackson SA, Schwartz GG. Cadmium and prostate cancer: a critical epidemiologic analysis. Cancer Invest. 2005;23:256–63.PubMedGoogle Scholar
  67. 67.
    Verougstraete V, Lison D, Hotz P. Cadmium, lung and prostate cancer: a systematic review of recent epidemiological data. J Toxicol Environ Health B Crit Rev. 2003;6:227–55.PubMedGoogle Scholar
  68. 68.
    Sorahan T, Esmen NA. Lung cancer mortality in UK nickel-cadmium battery workers, 1947–2000. Occup Environ Med. 2004;61:108–16.PubMedCentralPubMedGoogle Scholar
  69. 69.
    Vinceti M, Venturelli M, Sighinolfi C, Trerotoli P, Bonvicini F, Ferrari A, Bianchi G, Serio G, Bergomi M, Vivoli G. Case-control study of toenail cadmium and prostate cancer risk in Italy. Sci Total Environ. 2007;373:77–81.PubMedGoogle Scholar
  70. 70.
    Chen YC, Pu YS, Wu HC, Wu TT, Lai MK, Yang CY, Sung FC. Cadmium burden and the risk and phenotype of prostate cancer. BMC Cancer. 2009;9:429.PubMedCentralPubMedGoogle Scholar
  71. 71.
    Blair A, Freeman LB. Epidemiologic studies in agricultural populations: observations and future directions. J Agromedicine. 2009;14:125–31.PubMedCentralPubMedGoogle Scholar
  72. 72.
    Acquavella J, Olsen G, Cole P, Ireland B, Kaneene J, Schuman S, Holden L. Cancer among farmers: a meta-analysis. Ann Epidemiol. 1998;8:64–74.PubMedGoogle Scholar
  73. 73.
    Van Maele-Fabry G, Willems JL. Occupation related pesticide exposure and cancer of the prostate: a meta-analysis. Occup Environ Med. 2003;60:634–42.PubMedCentralPubMedGoogle Scholar
  74. 74.
    Van Maele-Fabry G, Willems JL. Prostate cancer among pesticide applicators: a meta-analysis. Int Arch Occup Environ Health. 2004;77:559–70.PubMedGoogle Scholar
  75. 75.
    Van Maele-Fabry G, Libotte V, Willems J, Lison D. Review and meta-analysis of risk estimates for prostate cancer in pesticide manufacturing workers. Cancer Causes Control. 2006;17:353–73.PubMedGoogle Scholar
  76. 76.
    Mink PJ, Adami HO, Trichopoulos D, Britton NL, Mandel JS. Pesticides and prostate cancer: a review of epidemiologic studies with specific agricultural exposure information. Eur J Cancer Prev. 2008;17:97–110.PubMedGoogle Scholar
  77. 77.
    Jones DR, Sutton AJ, Abrams KR, Fenty J, Warren F, Rushton L. Systematic review and meta-analysis of mortality in crop protection product manufacturing workers. Occup Environ Med. 2009;66:7–15.PubMedGoogle Scholar
  78. 78.
    Blair A, Zahm SH, Pearce NE, Heineman EF, Fraumeni Jr JF. Clues to cancer etiology from studies of farmers. Scand J Work Environ Health. 1992;18:209–15.PubMedGoogle Scholar
  79. 79.
    Van Der Gulden JW, Vogelzang PF. Farmers at risk for prostate cancer. Br J Urol. 1996;77:6–14.Google Scholar
  80. 80.
    Keller-Byrne JE, Khuder SA, Schaub EA. Meta-analyses of prostate cancer and farming. Am J Ind Med. 1997;31:580–6.PubMedGoogle Scholar
  81. 81.
    Kogevinas M, Becher H, Benn T, Bertazzi PA, Boffetta P, Bueno-de-Mesquita HB, Coggon D, Colin D, Flesch-Janys D, Fingerhut M, Green L, Kauppinen T, Littorin M, Lynge E, Mathews JD, Neuberger M, Pearce N, Saracci R. Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols, and dioxins. An expanded and updated international cohort study. Am J Epidemiol. 1997;145:1061–75.PubMedGoogle Scholar
  82. 82.
    Koutros S, Alavanja MC, Lubin JH, Sandler DP, Hoppin JA, Lynch CF, Knott C, Blair A, Freeman LE. An update of cancer incidence in the Agricultural Health Study. J Occup Environ Med. 2010;52:1098–105.PubMedCentralPubMedGoogle Scholar
  83. 83.
    Waggoner JK, Kullman GJ, Henneberger PK, Umbach DM, Blair A, Alavanja MC, Kamel F, Lynch CF, Knott C, London SJ, Hines CJ, Thomas KW, Sandler DP, Lubin JH, Beane Freeman LE, Hoppin JA. Mortality in the agricultural health study. Am J Epidemiol. 1993–2007;173:71–83.Google Scholar
  84. 84.
    Alavanja MC, Samanic C, Dosemeci M, Lubin J, Tarone R, Lynch CF, Knott C, Thomas K, Hoppin JA, Barker J, Coble J, Sandler DP, Blair A. Use of agricultural pesticides and prostate cancer risk in the Agricultural Health Study cohort. Am J Epidemiol. 2003;157:800–14.PubMedGoogle Scholar
  85. 85.
    Weichenthal S, Moase C, Chan P. A review of pesticide exposure and cancer incidence in the Agricultural Health Study cohort. Environ Health Perspect. 2010;118:1117–25.PubMedCentralPubMedGoogle Scholar
  86. 86.
    Purdue MP, Hoppin JA, Blair A, Dosemeci M, Alavanja MC. Occupational exposure to organochlorine insecticides and cancer incidence in the Agricultural Health Study. Int J Cancer. 2007;120:642–9.PubMedCentralPubMedGoogle Scholar
  87. 87.
    Mahajan R, Blair A, Lynch CF, Schroeder P, Hoppin JA, Sandler DP, Alavanja MC. Fonofos exposure and cancer incidence in the Agricultural Health Study. Environ Health Perspect. 2006;114:1838–42.PubMedCentralPubMedGoogle Scholar
  88. 88.
    Lynch SM, Mahajan R, Beane Freeman LE, Hoppin JA, Alavanja MC. Cancer incidence among pesticide applicators exposed to butylate in the Agricultural Health Study (AHS). Environ Res. 2009;109:860–8.PubMedCentralPubMedGoogle Scholar
  89. 89.
    Christensen CH, Platz EA, Andreotti G, Blair A, Hoppin JA, Koutros S, Lynch CF, Sandler DP, Alavanja MC. Coumaphos exposure and incident cancer among male participants in the Agricultural Health Study (AHS). Environ Health Perspect. 2010;118:92–6.PubMedCentralPubMedGoogle Scholar
  90. 90.
    Rusiecki JA, Patel R, Koutros S, Beane-Freeman L, Landgren O, Bonner MR, Coble J, Lubin J, Blair A, Hoppin JA, Alavanja MC. Cancer incidence among pesticide applicators exposed to permethrin in the Agricultural Health Study. Environ Health Perspect. 2009;117:581–6.PubMedCentralPubMedGoogle Scholar
  91. 91.
    Mahajan R, Bonner MR, Hoppin JA, Alavanja MC. Phorate exposure and incidence of cancer in the Agricultural Health Study. Environ Health Perspect. 2006;114:1205–9.PubMedCentralPubMedGoogle Scholar
  92. 92.
    Koutros S, Beane Freeman LE, Berndt SI, Andreotti G, Lubin JH, Sandler DP, Hoppin JA, Yu K, Li Q, Burdette LA, Yuenger J, Yeager M, Alavanja MC. Pesticide use modifies the association between genetic variants on chromosome 8q24 and prostate cancer. Cancer Res. 2010;70:9224–33.PubMedCentralPubMedGoogle Scholar
  93. 93.
    Mills PK, Yang R. Prostate cancer risk in California farm workers. J Occup Environ Med. 2003;45:249–58.PubMedGoogle Scholar
  94. 94.
    Settimi L, Masina A, Andrion A, Axelson O. Prostate cancer and exposure to pesticides in agricultural settings. Int J Cancer. 2003;104:458–61.PubMedGoogle Scholar
  95. 95.
    Band PR, Abanto Z, Bert J, Lang B, Fang R, Gallagher RP, Le ND. Prostate cancer risk and exposure to pesticides in British Columbia farmers. Prostate. 2011;71:168–83.PubMedGoogle Scholar
  96. 96.
    Cockburn M, Mills P, Zhang X, Zadnick J, Goldberg D, Ritz B. Prostate cancer and ambient pesticide exposure in agriculturally intensive areas in California. Am J Epidemiol. 2011;173:1280–8.PubMedCentralPubMedGoogle Scholar
  97. 97.
    Sawada N, Iwasaki M, Inoue M, Itoh H, Sasazuki S, Yamaji T, Shimazu T, Tsugane S. Plasma organochlorines and subsequent risk of prostate cancer in Japanese men: a nested case-control study. Environ Health Perspect. 2010;118:659–65.PubMedCentralPubMedGoogle Scholar
  98. 98.
    Xu X, Dailey AB, Talbott EO, Ilacqua VA, Kearney G, Asal NR. Associations of serum concentrations of organochlorine pesticides with breast cancer and prostate cancer in U.S. adults. Environ Health Perspect. 2010;118:60–6.PubMedCentralPubMedGoogle Scholar
  99. 99.
    Ritchie JM, Vial SL, Fuortes LJ, Guo H, Reedy VE, Smith EM. Organochlorines and risk of prostate cancer. J Occup Environ Med. 2003;45:692–702.PubMedGoogle Scholar
  100. 100.
    Hardell L, Andersson SO, Carlberg M, Bohr L, van Bavel B, Lindstrom G, Bjornfoth H, Ginman C. Adipose tissue concentrations of persistent organic pollutants and the risk of prostate cancer. J Occup Environ Med. 2006;48:700–7.PubMedGoogle Scholar
  101. 101.
    Leon ME, Beane Freeman LE, Douwes J, Hoppin JA, Kromhout H, Lebailly P, Nordby KC, Schenker M, Schuz J, Waring SC, Alavanja MC, Annesi-Maesano I, Baldi I, Dalvie MA, Ferro G, Fervers B, Langseth H, London L, Lynch CF, McLaughlin J, Merchant JA, Pahwa P, Sigsgaard T, Stayner L, Wesseling C, Yoo KY, Zahm SH, Straif K, Blair A. AGRICOH: a consortium of agricultural cohorts. Int J Environ Res Public Health. 2011;8:1341–57.PubMedCentralPubMedGoogle Scholar
  102. 102.
    Cocco P. On the rumors about the silent spring. Review of the scientific evidence linking occupational and environmental pesticide exposure to endocrine disruption health effects. Cad Saude Publica. 2002;18:379–402.PubMedGoogle Scholar
  103. 103.
    IARC. Re-evaluation of Some organic chemicals, hydrazine and hydrogen peroxide, vol. 71. Lyon: IARC; 1999.Google Scholar
  104. 104.
    Bolognesi C. Genotoxicity of pesticides: a review of human biomonitoring studies. Mutat Res. 2003;543:251–72.PubMedGoogle Scholar
  105. 105.
    Klaunig JE, Xu Y, Isenberg JS, Bachowski S, Kolaja KL, Jiang J, Stevenson DE, Walborg Jr EF. The role of oxidative stress in chemical carcinogenesis. Environ Health Perspect. 1998;106 Suppl 1:289–95.PubMedCentralPubMedGoogle Scholar
  106. 106.
    Prins GS. Endocrine disruptors and prostate cancer risk. Endocr Relat Cancer. 2008;15:649–56.PubMedCentralPubMedGoogle Scholar
  107. 107.
    Prince MM, Ruder AM, Hein MJ, Waters MA, Whelan EA, Nilsen N, Ward EM, Schnorr TM, Laber PA, Davis-King KE. Mortality and exposure response among 14,458 electrical capacitor manufacturing workers exposed to polychlorinated biphenyls (PCBs). Environ Health Perspect. 2006;114:1508–14.PubMedCentralPubMedGoogle Scholar
  108. 108.
    Gustavsson P, Hogstedt C. A cohort study of Swedish capacitor manufacturing workers exposed to polychlorinated biphenyls (PCBs). Am J Ind Med. 1997;32:234–9.PubMedGoogle Scholar
  109. 109.
    Yassi A, Tate RB, Routledge M. Cancer incidence and mortality in workers employed at a transformer manufacturing plant: update to a cohort study. Am J Ind Med. 2003;44:58–62.PubMedGoogle Scholar
  110. 110.
    Ruder AM, Hein MJ, Nilsen N, Waters MA, Laber P, Davis-King K, Prince MM, Whelan E. Mortality among workers exposed to polychlorinated biphenyls (PCBs) in an electrical capacitor manufacturing plant in Indiana: an update. Environ Health Perspect. 2006;114:18–23.PubMedCentralPubMedGoogle Scholar
  111. 111.
    Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. GLOBOCAN 2008, cancer incidence and mortality worldwide: IARC cancer base no. 10 [internet]. Lyon: International Agency for Research on cancer; 2010.Google Scholar
  112. 112.
    Richiardi L, Bellocco R, Adami HO, Torrang A, Barlow L, Hakulinen T, Rahu M, Stengrevics A, Storm H, Tretli S, Kurtinaitis J, Tyczynski JE, Akre O. Testicular cancer incidence in eight northern European countries: secular and recent trends. Cancer Epidemiol Biomarkers Prev. 2004;13:2157–66.PubMedGoogle Scholar
  113. 113.
    Chia VM, Quraishi SM, Devesa SS, Purdue MP, Cook MB, McGlynn KA. International trends in the incidence of testicular cancer, 1973–2002. Cancer Epidemiol Biomarkers Prev. 2010;19:1151–9.PubMedCentralPubMedGoogle Scholar
  114. 114.
    Richiardi L, Tamimi R, Adami HO. Testicular cancer. In: Adami HO, Hunter D, Trichopoulos D, editors. Textbook of cancer epidemiology. 2nd ed. New York: Oxford University Press; 2008. p. 555–72.Google Scholar
  115. 115.
    Sonne SB, Almstrup K, Dalgaard M, Juncker AS, Edsgard D, Ruban L, Harrison NJ, Schwager C, Abdollahi A, Huber PE, Brunak S, Gjerdrum LM, Moore HD, Andrews PW, Skakkebaek NE, Rajpert-De Meyts E, Leffers H. Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte. Cancer Res. 2009;69:5241–50.PubMedCentralPubMedGoogle Scholar
  116. 116.
    Cook MB, Akre O, Forman D, Madigan MP, Richiardi L, McGlynn KA. A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer – experiences of the mother. Int J Epidemiol. 2009;38:1532–42.PubMedCentralPubMedGoogle Scholar
  117. 117.
    Cook MB, Akre O, Forman D, Madigan MP, Richiardi L, McGlynn KA. A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer–experiences of the son. Int J Epidemiol. 2010;39:1605–18.PubMedCentralPubMedGoogle Scholar
  118. 118.
    Sharpe RM, Skakkebaek NE. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet. 1993;341:1392–5.PubMedGoogle Scholar
  119. 119.
    Henderson BE, Benton B, Jing J, Yu MC, Pike MC. Risk factors for cancer of the testis in young men. Int J Cancer. 1979;23:598–602.PubMedGoogle Scholar
  120. 120.
    Sharpe RM. The ‘oestrogen hypothesis’ – where do we stand now? Int J Androl. 2003;26:2–15.PubMedGoogle Scholar
  121. 121.
    Sharpe RM, Skakkebaek NE. Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects. Fertil Steril. 2008;89:e33–8.PubMedGoogle Scholar
  122. 122.
    Martin OV, Shialis T, Lester JN, Scrimshaw MD, Boobis AR, Voulvoulis N. Testicular dysgenesis syndrome and the estrogen hypothesis: a quantitative meta-analysis. Environ Health Perspect. 2008;116:149–57.PubMedCentralPubMedGoogle Scholar
  123. 123.
    Skakkebaek NE, Rajpert-De Meyts E, Main KM. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod. 2001;16:972–8.PubMedGoogle Scholar
  124. 124.
    Akre O, Richiardi L. Does a testicular dysgenesis syndrome exist? Hum Reprod. 2009;24:2053–60.PubMedGoogle Scholar
  125. 125.
    Peng X, Zeng X, Peng S, Deng D, Zhang J. The association risk of male subfertility and testicular cancer: a systematic review. PLoS One. 2009;4:e5591.PubMedCentralPubMedGoogle Scholar
  126. 126.
    Lerro CC, McGlynn KA, Cook MB. A systematic review and meta-analysis of the relationship between body size and testicular cancer. Br J Cancer. 2010;103:1467–74.PubMedCentralPubMedGoogle Scholar
  127. 127.
    Pettersson A, Richiardi L, Nordenskjold A, Kaijser M, Akre O. Age at surgery for undescended testis and risk of testicular cancer. N Engl J Med. 2007;356:1835–41.PubMedGoogle Scholar
  128. 128.
    Richiardi L, Pettersson A, Akre O. Genetic and environmental risk factors for testicular cancer. Int J Androl. 2007;30:230–40. discussion 40–1.PubMedGoogle Scholar
  129. 129.
    Turnbull C, Rapley EA, Seal S, Pernet D, Renwick A, Hughes D, Ricketts M, Linger R, Nsengimana J, Deloukas P, Huddart RA, Bishop DT, Easton DF, Stratton MR, Rahman N. Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer. Nat Genet. 2010;42:604–7.PubMedCentralPubMedGoogle Scholar
  130. 130.
    Kanetsky PA, Mitra N, Vardhanabhuti S, Li M, Vaughn DJ, Letrero R, Ciosek SL, Doody DR, Smith LM, Weaver J, Albano A, Chen C, Starr JR, Rader DJ, Godwin AK, Reilly MP, Hakonarson H, Schwartz SM, Nathanson KL. Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. Nat Genet. 2009;41:811–5.PubMedCentralPubMedGoogle Scholar
  131. 131.
    Rapley EA, Turnbull C, Al Olama AA, Dermitzakis ET, Linger R, Huddart RA, Renwick A, Hughes D, Hines S, Seal S, Morrison J, Nsengimana J, Deloukas P, Rahman N, Bishop DT, Easton DF, Stratton MR. A genome-wide association study of testicular germ cell tumor. Nat Genet. 2009;41:807–10.PubMedCentralPubMedGoogle Scholar
  132. 132.
    Mills PK, Newell GR, Johnson DE. Testicular cancer associated with employment in agriculture and oil and natural gas extraction. Lancet. 1984;1:207–10.PubMedGoogle Scholar
  133. 133.
    Zhang ZF, Vena JE, Zielezny M, Graham S, Haughey BP, Brasure J, Marshall JR. Occupational exposure to extreme temperature and risk of testicular cancer. Arch Environ Health. 1995;50:13–8.PubMedGoogle Scholar
  134. 134.
    Hardell L, Ohlson CG, Fredrikson M. Occupational exposure to polyvinyl chloride as a risk factor for testicular cancer evaluated in a case-control study. Int J Cancer. 1997;73:828–30.PubMedGoogle Scholar
  135. 135.
    Andersson E, Nilsson R, Toren K. Testicular cancer among Swedish pulp and paper workers. Am J Ind Med. 2003;43:642–6.PubMedGoogle Scholar
  136. 136.
    Hardell L, Malmqvist N, Ohlson CG, Westberg H, Eriksson M. Testicular cancer and occupational exposure to polyvinyl chloride plastics: a case-control study. Int J Cancer. 2004;109:425–9.PubMedGoogle Scholar
  137. 137.
    Guo J, Pukkala E, Kyyronen P, Lindbohm ML, Heikkila P, Kauppinen T. Testicular cancer, occupation and exposure to chemical agents among Finnish men in 1971–1995. Cancer Causes Control. 2005;16:97–103.PubMedGoogle Scholar
  138. 138.
    Langner I, Schmeisser N, Mester B, Behrens T, Gottlieb A, Ahrens W. Case-control study of male germ cell tumors nested in a cohort of car-manufacturing workers: findings from the occupational history. Am J Ind Med. 2010;53:1006–18.PubMedGoogle Scholar
  139. 139.
    Pearce N, Sheppard RA, Howard JK, Fraser J, Lilley BM. Time trends and occupational differences in cancer of the testis in New Zealand. Cancer. 1987;59:1677–82.PubMedGoogle Scholar
  140. 140.
    Haughey BP, Graham S, Brasure J, Zielezny M, Sufrin G, Burnett WS. The epidemiology of testicular cancer in upstate New York. Am J Epidemiol. 1989;130:25–36.PubMedGoogle Scholar
  141. 141.
    Hayes RB, Brown LM, Pottern LM, Gomez M, Kardaun JW, Hoover RN, O’Connell KJ, Sutzman RE, Javadpour N. Occupation and risk for testicular cancer: a case-control study. Int J Epidemiol. 1990;19:825–31.PubMedGoogle Scholar
  142. 142.
    Swerdlow AJ, Douglas AJ, Huttly SR, Smith PG. Cancer of the testis, socioeconomic status, and occupation. Br J Ind Med. 1991;48:670–4.PubMedCentralPubMedGoogle Scholar
  143. 143.
    Van den Eeden SK, Weiss NS, Strader CH, Daling JR. Occupation and the occurrence of testicular cancer. Am J Ind Med. 1991;19:327–37.PubMedGoogle Scholar
  144. 144.
    UK Testicular Cancer Study Group. Social, behavioural and medical factors in the aetiology of testicular cancer: results from the UK study. Br J Cancer. 1994;70:513–20.Google Scholar
  145. 145.
    Rhomberg W, Schmoll HJ, Schneider B. High frequency of metalworkers among patients with seminomatous tumors of the testis: a case-control study. Am J Ind Med. 1995;28:79–87.PubMedGoogle Scholar
  146. 146.
    Knight JA, Marrett LD, Weir HK. Occupation and risk of germ cell testicular cancer by histologic type in Ontario. J Occup Environ Med. 1996;38:884–90.PubMedGoogle Scholar
  147. 147.
    Hobbesland A, Kjuus H, Thelle DS. Study of cancer incidence among 8530 male workers in eight Norwegian plants producing ferrosilicon and silicon metal. Occup Environ Med. 1999;56:625–31.PubMedCentralPubMedGoogle Scholar
  148. 148.
    Pollan M, Gustavsson P, Cano MI. Incidence of testicular cancer and occupation among Swedish men gainfully employed in 1970. Ann Epidemiol. 2001;11:554–62.PubMedGoogle Scholar
  149. 149.
    Whorton MD, Moore DN, Seward JP, Noonan KA, Mendelsohn ML. Cancer incidence rates among Lawrence Livermore National Laboratory (LLNL) employees: 1974–1997. Am J Ind Med. 2004;45:24–33.PubMedGoogle Scholar
  150. 150.
    Walschaerts M, Muller A, Auger J, Bujan L, Guerin JF, Le Lannou D, Clavert A, Spira A, Jouannet P, Thonneau P. Environmental, occupational and familial risks for testicular cancer: a hospital-based case-control study. Int J Androl. 2007;30:222–9.PubMedGoogle Scholar
  151. 151.
    Garland FC, Gorham ED, Garland CF, Ducatman AM. Testicular cancer in US Navy personnel. Am J Epidemiol. 1988;127:411–4.PubMedGoogle Scholar
  152. 152.
    Tarone RE, Hayes HM, Hoover RN, Rosenthal JF, Brown LM, Pottern LM, Javadpour N, O’Connell KJ, Stutzman RE. Service in Vietnam and risk of testicular cancer. J Natl Cancer Inst. 1991;83:1497–9.PubMedGoogle Scholar
  153. 153.
    Foley S, Middleton S, Stitson D, Mahoney M. The incidence of testicular cancer in Royal Air Force personnel. Br J Urol. 1995;76:495–6.PubMedGoogle Scholar
  154. 154.
    Young HA, Maillard JD, Levine PH, Simmens SJ, Mahan CM, Kang HK. Investigating the risk of cancer in 1990–1991 US Gulf War veterans with the use of state cancer registry data. Ann Epidemiol. 2010;20:265–72 e1.PubMedGoogle Scholar
  155. 155.
    Gray GC, Coate BD, Anderson CM, Kang HK, Berg SW, Wignall FS, Knoke JD, Barrett-Connor E. The postwar hospitalization experience of U.S. veterans of the Persian Gulf War. N Engl J Med. 1996;335:1505–13.PubMedGoogle Scholar
  156. 156.
    Knoke JD, Gray GC, Garland FC. Testicular cancer and Persian Gulf War service. Epidemiology. 1998;9:648–53.PubMedGoogle Scholar
  157. 157.
    Macfarlane GJ, Biggs AM, Maconochie N, Hotopf M, Doyle P, Lunt M. Incidence of cancer among UK Gulf war veterans: cohort study. BMJ. 2003;327:1373.PubMedCentralPubMedGoogle Scholar
  158. 158.
    Zhu K, Devesa SS, Wu H, Zahm SH, Jatoi I, Anderson WF, Peoples GE, Maxwell LG, Granger E, Potter JF, McGlynn KA. Cancer incidence in the U.S. military population: comparison with rates from the SEER program. Cancer Epidemiol Biomarkers Prev. 2009;18:1740–5.PubMedCentralPubMedGoogle Scholar
  159. 159.
    Frost G, Brown T, Harding AH. Mortality and cancer incidence among British agricultural pesticide users. Occup Med (Lond). 2011;61:303–10.Google Scholar
  160. 160.
    MacFarlane E, Benke G, Del Monaco A, Sim MR. Cancer incidence and mortality in a historical cohort of Australian pest control workers. Occup Environ Med. 2009;66:818–23.PubMedGoogle Scholar
  161. 161.
    Fleming LE, Bean JA, Rudolph M, Hamilton K. Cancer incidence in a cohort of licensed pesticide applicators in Florida. J Occup Environ Med. 1999;41:279–88.PubMedGoogle Scholar
  162. 162.
    Dich J, Wiklund K, Holm LE. Testicular cancer in pesticide applicators in Swedish agriculture. Scand J Work Environ Health. 1996;22:66.PubMedGoogle Scholar
  163. 163.
    Wiklund K, Dich J, Holm LE, Eklund G. Risk of cancer in pesticide applicators in Swedish agriculture. Br J Ind Med. 1989;46:809–14.PubMedCentralPubMedGoogle Scholar
  164. 164.
    Wiklund K, Dich J. Cancer risks among male farmers in Sweden. Eur J Cancer Prev. 1995;4:81–90.PubMedGoogle Scholar
  165. 165.
    Fleming LE, Bean JA, Rudolph M, Hamilton K. Mortality in a cohort of licensed pesticide applicators in Florida. Occup Environ Med. 1999;56:14–21.PubMedCentralPubMedGoogle Scholar
  166. 166.
    Kristensen P, Andersen A, Irgens LM, Laake P, Bye AS. Incidence and risk factors of cancer among men and women in Norwegian agriculture. Scand J Work Environ Health. 1996;22:14–26.PubMedGoogle Scholar
  167. 167.
    Zhong Y, Rafnsson V. Cancer incidence among Icelandic pesticide users. Int J Epidemiol. 1996;25:1117–24.PubMedGoogle Scholar
  168. 168.
    MacFarlane E, Benke G, Del Monaco A, Sim MR. Causes of death and incidence of cancer in a cohort of Australian pesticide-exposed workers. Ann Epidemiol. 2010;20:273–80.PubMedGoogle Scholar
  169. 169.
    Cook MB, Trabert B, McGlynn KA. Organochlorine compounds and testicular dysgenesis syndrome: human data. Int J Androl. 2011;34:e68–85.PubMedCentralPubMedGoogle Scholar
  170. 170.
    Hardell L, van Bavel B, Lindstrom G, Carlberg M, Dreifaldt AC, Wijkstrom H, Starkhammar H, Eriksson M, Hallquist A, Kolmert T. Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer. Environ Health Perspect. 2003;111:930–4.PubMedCentralPubMedGoogle Scholar
  171. 171.
    Biggs ML, Davis MD, Eaton DL, Weiss NS, Barr DB, Doody DR, Fish S, Needham LL, Chen C, Schwartz SM. Serum organochlorine pesticide residues and risk of testicular germ cell carcinoma: a population-based case-control study. Cancer Epidemiol Biomarkers Prev. 2008;17:2012–8.PubMedCentralPubMedGoogle Scholar
  172. 172.
    McGlynn KA, Quraishi SM, Graubard BI, Weber JP, Rubertone MV, Erickson RL. Persistent organochlorine pesticides and risk of testicular germ cell tumors. J Natl Cancer Inst. 2008;100:663–71.PubMedGoogle Scholar
  173. 173.
    Purdue MP, Engel LS, Langseth H, Needham LL, Andersen A, Barr DB, Blair A, Rothman N, McGlynn KA. Prediagnostic serum concentrations of organochlorine compounds and risk of testicular germ cell tumors. Environ Health Perspect. 2009;117:1514–9.PubMedCentralPubMedGoogle Scholar
  174. 174.
    Kristensen P, Andersen A, Irgens LM, Bye AS, Vagstad N. Testicular cancer and parental use of fertilizers in agriculture. Cancer Epidemiol Biomarkers Prev. 1996;5:3–9.PubMedGoogle Scholar
  175. 175.
    Rodvall Y, Dich J, Wiklund K. Cancer risk in offspring of male pesticide applicators in agriculture in Sweden. Occup Environ Med. 2003;60:798–801.PubMedCentralPubMedGoogle Scholar
  176. 176.
    Moller H. Work in agriculture, childhood residence, nitrate exposure, and testicular cancer risk: a case-control study in Denmark. Cancer Epidemiol Biomarkers Prev. 1997;6:141–4.PubMedGoogle Scholar
  177. 177.
    Kardaun JW, Hayes RB, Pottern LM, Brown LM, Hoover RN. Testicular cancer in young men and parental occupational exposure. Am J Ind Med. 1991;20:219–27.PubMedGoogle Scholar

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© Springer-Verlag London 2014

Authors and Affiliations

  1. 1.Cancer Epidemiology Unit, Department of Medical SciencesUniveristy of Turin, and CPO-PiemonteTorinoItaly
  2. 2.MRC Integrative Epidemiology Unit, School of Social and Community MedicineUniversity of BristolBristolUK

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