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Malignant Neoplasms of the Skin

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Occupational Cancers

Abstract

Malignant neoplasms of the skin comprise a group of cancers often less commonly considered occupational than many other types of cancers related to workplace exposures, such as mesothelioma, lung, or bladder cancer. One reason for this is that skin neoplasms are very common in the community and the main causal exposure, sunlight, is ubiquitous. Therefore, occupational risk factors may not be recognized when a case of skin cancer is diagnosed.

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References

  1. Pott P. Chirurgical observations relative to the cataract, the polypus of the nose, the cancer of the scrotum, the different kinds of ruptures and the mortification of the toes and feet. London: T.J. Carnegy; 1775. p. 63–8.

    Google Scholar 

  2. Southam AH, Wilson SR. Cancer of the scrotum: the etiology, clinical features, and treatment of the disease. Br Med J. 1922;2(3229):971–3.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Gallagher RP, Hill GB, Bajdik CD, et al. Sunlight exposure, pigmentary factors, and risk of nonmelanocytic skin cancer. 1. Basal cell carcinoma. Arch Dermatol. 1995;131:157–63.

    Article  CAS  PubMed  Google Scholar 

  4. McCormack CJ, Kelly JW, Dorevitch AP. Differences in age and body site distribution of the histological subtypes of basal cell carcinoma: possible indicator of differing causes. Arch Dermatol. 1997;133:593–6.

    Article  CAS  PubMed  Google Scholar 

  5. Stacey SM, Sulam P, Masson G, et al. New common variants affecting susceptibility to basal cell carcinoma. Nat Genet. 2009;41(8):909–14. Epub 2009 Jul 5.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Miki Y. Basal cell epithelioma among Japanese. Australas J Dermatol. 1968;9:304–13.

    Article  CAS  PubMed  Google Scholar 

  7. Shanmugaranam K, Labrooy EB. Skin cancer in Singapore. Washington, DC: National Cancer Institute; 1963. p. 127–40. Monograph 10.

    Google Scholar 

  8. Robinson JK. Risk of developing a basal cell carcinoma. A 5 year prospective study. Cancer. 1987;60(1):118–20.

    Article  CAS  PubMed  Google Scholar 

  9. Lindelof B, Sigurgeirsson B, Gabel H, et al. Incidence of skin cancer in 5356 patients following organ transplantation. Br J Dermatol. 2000;143:513–9.

    CAS  PubMed  Google Scholar 

  10. Euvrard S, Kanitakis J, Pouteil-Noble C, et al. Comparative epidemiologic study on premalignant and malignant epithelial cutaneous lesions developing after kidney and heart transplantation. J Am Acad Dermatol. 1995;33:222–9.

    Article  CAS  PubMed  Google Scholar 

  11. Glogau RG. The risk of progression to invasive disease. J Am Acad Dermatol. 2000;42(1 Pt 2):23–4.

    Article  CAS  PubMed  Google Scholar 

  12. Marks R, Rennie G, Selwood TS. Malignant transformation of solar keratoses to squamous cell carcinoma. Lancet. 1988;1(8589):795–7.

    Article  CAS  PubMed  Google Scholar 

  13. Australian Institute of Health and Welfare. http://www.aihw.gov.au/cancer/#incidence. Accessed 15 Feb 2012.

  14. Gandini S, Sera F, Cattaruzza MS, et al. Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure. Eur J Cancer. 2005;41:45–60.

    Article  PubMed  Google Scholar 

  15. Rhodes AR, Weinstock MA, Fitzpatrick TB, et al. Risk factors for cutaneous melanoma. A practical method of recognizing predisposed individuals. JAMA. 1987;258:3146–54.

    Article  CAS  PubMed  Google Scholar 

  16. Piepkorn M. Melanoma genetics: an update with focus on the CDKN2A p1 tumor suppressors. J Am Acad Dermatol. 2000;42:705–22.

    Article  CAS  PubMed  Google Scholar 

  17. Wolff K, Goldsmith LA, Katz SI, et al. Chapter 124: cutaneous melanoma. Fitzpatrick’s Dermatology in General Medicine. 7th ed. United Kingdom: McGraw-Hill Medical, NY 2008.

    Google Scholar 

  18. Burns T, Breathnach S, Cox N, Griffiths C. Chapter 54: lentigos, melanocytic naevi and melanoma. Rook’s Textbook of Dermatology. 8th ed. Boston: Wiley and Blackwell Publishing UK 2010.

    Google Scholar 

  19. Schwartz RA, Bridges TM, Butani AK, Ehrlich A. Actinic keratosis: an occupational and environmental disorder. J Eur Acad Dermatol Venereol. 2008;22:606–15.

    Article  CAS  PubMed  Google Scholar 

  20. Baan R, Grosse Y, Straif K, et al. A review of human carcinogens – Part F : chemical agents and related occupations. Lancet Oncol. 2009;10:1143–4.

    Article  PubMed  Google Scholar 

  21. Boffetta P, Jourenkova N, Gustavson P. Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons. Cancer Causes Control. 1997;8:444–72.

    Article  CAS  PubMed  Google Scholar 

  22. Randem BG, Burstyn I, Langard S, Svane O, Jarvholm B, Kauppinen T, Bergdahl IA, Johansen C, Hansen J, Partanen T, Kromhout H, Ferro G, Boffetta P. Cancer incidence of Nordic asphalt workers. Scand J Work Environ Health. 2004;30(5):350–5.

    Article  PubMed  Google Scholar 

  23. Wong O, Raabe GK. A critical review of cancer epidemiology in the petroleum industry, with a meta-analysis of a combined database of more than 350,000 workers. Regul Toxicol Pharmacol. 2000;32:78–98.

    Article  CAS  PubMed  Google Scholar 

  24. Sorahan T. Mortality of UK oil refinery and petroleum distribution workers, 1951–2003. Occup Med. 2007;57:177–85.

    Article  Google Scholar 

  25. Gun RT, Pratt N, Ryan P, Roder D. Update of mortality and cancer incidence in the Australian petroleum industry cohort. Occup Environ Med. 2006;63:476–81.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  26. Chen Y, Parvez F, Gamble M, Islam T, et al. Arsenic exposure at low-to-moderate levels and skin lesions, arsenic metabolism, neurological functions, and biomarkers for respiratory and cardiovascular diseases: review of recent findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh. Toxicol Appl Pharmacol. 2009;239:184–92.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  27. Suárez B, López-Abente G, Martínez C, Navarro C, et al. Occupation and skin cancer: the results of the HELIOS-I multicenter case-control study. BMC Public Health. 2007;7:180.

    Article  PubMed Central  PubMed  Google Scholar 

  28. Calvert GM, Ward E, Schnorr TM, Fine LJ. Cancer risks among workers exposed to metalworking fluids: a systematic review. Am J Ind Med. 1998;33:282–92.

    Article  CAS  PubMed  Google Scholar 

  29. Costello S, Friesen MC, Christiani DC, Eisen EA. Metalworking fluids and malignant melanoma in autoworkers. Epidemiology. 2011;22:90–7.

    Article  PubMed  Google Scholar 

  30. Band PR, Le ND, Fang R, Astrakianakis G, Bert J, Keefe A, Krewski D. Cohort cancer incidence among pulp and paper mill workers in British Columbia. Scand J Work Environ Health. 2001;27(2):113–9.

    Article  CAS  PubMed  Google Scholar 

  31. Puntoni R, Ceppi M, Gennaro V, Ugolini D, et al. Occupational exposure to carbon black and risk of cancer. Cancer Causes Control. 2004;15(5):511–6.

    Article  PubMed  Google Scholar 

  32. Dennis LK, Lynch CF, Sandier DP, Alavanja MCR. Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural health study. Environ Health Perspect. 2010;118(6):812–7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  33. Young C. Solar ultraviolet radiation and skin cancer. Occup Med. 2009;59:82–8.

    Article  Google Scholar 

  34. Hakansson N, Floderus B, Gustavsson P, Feychting M, Hallin N. Occupational sunlight exposure and cancer incidence among Swedish construction workers. Epidemiology. 2001;12:552–7.

    Article  CAS  PubMed  Google Scholar 

  35. Schmitt J, Seidler A, Diepgen TL, Bauer A. Occupational ultraviolet light exposure increases the risk for the development of cutaneous squamous cell carcinoma: a systematic review and meta-analysis. Br J Dermatol. 2011;164:291–307.

    Article  CAS  PubMed  Google Scholar 

  36. Bauer A, Diepgen TL, Schmitt J. Is occupational solar ultraviolet irradiation a relevant risk factor for basal cell carcinoma? A systematic review and meta-analysis of the epidemiological literature. Br J Dermatol. 2011;165:612–25.

    CAS  PubMed  Google Scholar 

  37. Kenborg L, Jørgensen AD, Budtz-Jørgensen E, Knudsen LE, Hansen J. Occupational exposure to the sun and risk of skin and lip cancer among male wage earners in Denmark: a population-based case–control study. Cancer Causes Control. 2010;21:1347–55.

    Article  PubMed  Google Scholar 

  38. Green A, Battistutta D, Hart V, Leslie D, Weedon D, Nambour Study Group. Skin cancer in sub-tropical Australian population: incidence and lack of association with occupation. Am J Epidemiol. 1996;144:1034–40.

    Article  CAS  PubMed  Google Scholar 

  39. Guénel P, Laforest L, Cyr D, Févotte J. Occupational risk factors, ultraviolet radiation, and ocular melanoma: a case-control study in France. Cancer Causes Control. 2001;12(5):451–9.

    Article  PubMed  Google Scholar 

  40. Ghissassi FE, Baan R, Straif K, et al. A review of human carcinogens – part D: radiation. Lancet Oncol. 2009;10:751–2.

    Article  PubMed  Google Scholar 

  41. Tokumaru O, Haruki K, Bacal K, Katagiri T, Yamamoto T, Sakurai Y. Incidence of cancer among female flight attendants: a meta-analysis. J Travel Med. 2006;13:127–32.

    Article  PubMed  Google Scholar 

  42. Buja A, Lange JH, Perissinotto E, Rausa G, et al. Cancer incidence among male military and civil pilots and flight attendants: an analysis on published data. Toxicol Ind Health. 2005;21:273–82.

    Article  PubMed  Google Scholar 

  43. Yoshinaga S, Hauptmann M, Sigurdson AJ, Doody MM, Freedman DM, Alexander BH, Linet MS, Ron E, Mabuchi K. Nonmelanoma skin cancer in relation to ionising radiation exposure among U.S. radiologic technologists. Int J Cancer. 2005;115:828–34.

    Article  CAS  PubMed  Google Scholar 

  44. Fink CA, Bates MN. Melanoma and ionizing radiation: is there a causal relationship? Radiat Res. 2005;164(5):701–10.

    Article  CAS  PubMed  Google Scholar 

  45. Linet MS, Kim KP, Miller DL, Kleinerman RA, et al. Historical review of occupational exposures and cancer risks in medical radiation workers. Radiat Res. 2010;174:793–808.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  46. Schernhammer ES, Razavi P, Li TY, Qureshi AA, Han J. Rotating night shifts and risk of skin cancer in the nurses’ health study. J Natl Cancer Inst. 2011;103:602–6.

    Article  PubMed Central  PubMed  Google Scholar 

  47. Lucas RM, McMichael AJ, Armstrong BK, Smith WT. Estimating the global disease burden due to ultraviolet radiation exposure. Int J Epidemiol. 2008;37(3):654–67.

    Article  PubMed  Google Scholar 

  48. Van der Leun JC, de Gruijl FR. Climate change and skin cancer. Photochem Photobiol Sci. 2002;1:324–6.

    Article  PubMed  Google Scholar 

  49. Kalia S, Haiducu ML. The burden of skin disease in the United States and Canada. Dermatol Clin. 2012;30:5–18.

    Article  CAS  PubMed  Google Scholar 

  50. Fritschi L, Driscoll T. Cancer due to occupation in Australia. Aust NZ J Public Health. 2006;30:213–9.

    Article  Google Scholar 

  51. Rushton L, Bagga S, Bevan R, Brown TP. Occupation and cancer in Britain. Br J Cancer. 2010;102(9):1428–37.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  52. McNamee R, Carder M, Chen Y, Agius R. Measurement of trends in incidence of work-related skin and respiratory diseases, UK 1996–2005. Occup Environ Med. 2008;65:808–14.

    Article  CAS  PubMed  Google Scholar 

  53. Turner S, Forman S, McNamee R, Carder M, Agius R. Investigating skin cancer case reporting to The Health and Occupation Reporting (THOR) network. Occup Environ Med. 2011;68:A38.

    Article  Google Scholar 

  54. Stocks SJ, Turner S, McNamee R, Carder M, Hussey L, Agius RM. Occupation and work-related ill-health in UK construction workers. Occup Med. 2011;61:407–15.

    Article  CAS  Google Scholar 

  55. LeBlanc WG Ph.D, Vidal L, Kirsner RS, Lee DJ. Reported skin cancer screening of US adult workers. J Am Acad Dermatol. 2008;59:55–63.

    Article  PubMed Central  PubMed  Google Scholar 

  56. Kütting B, Drexler H. UV-induced skin cancer at workplace and evidence-based prevention. Int Arch Occup Environ Health. 2010;83:843–54.

    Article  PubMed  Google Scholar 

  57. Giles P, Wright J. Measured solar ultraviolet radiation exposures of outdoor workers in Queensland in the building and construction industry. Photochem Photobiol. 2003;78:342–8.

    Article  Google Scholar 

  58. Glanz K, Buller DB, Saraiya M. Reducing ultraviolet radiation exposure among outdoor workers: state of the evidence and recommendations. Environ Health. 2007;6:22. doi:10.1186/1476-069X-6-22.

    Article  PubMed Central  PubMed  Google Scholar 

  59. Salas R, Mayer JA, Hoerster KD. Sun-protective behaviours of California farmworkers. J Occup Environ Med. 2005;47:1244–9.

    Article  PubMed  Google Scholar 

  60. Buller DB, Andersen PA, Walkosz BJ, Scott MD. Randomized trial testing a worksite sun protection program in an outdoor recreation industry. Health Educ Behav. 2005;32:514–35.

    Article  PubMed  Google Scholar 

  61. Mayer JA, Slymen DJ, Clapp EJ, Pichon LC. Promoting sun safety among US postal service letter carriers: impact of a 2-year intervention. Am J Public Health. 2007;97:559–65.

    Article  PubMed Central  PubMed  Google Scholar 

  62. Stock ML, Gerrard M, Gibbons FX. Sun protection intervention for highway workers: long-term efficacy of UV photography and skin cancer information on men’s protective cognitions and behaviour. Ann Behav Med. 2009;38:225–36.

    Article  PubMed Central  PubMed  Google Scholar 

  63. Lomas A, Leonardi-Bee J, Bath-Hextall F. A systematic review of worldwide incidence of non-melanoma skin cancer. Br J Dermatol. 2012;166:1069–80.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Malcolm R. Sim BMedSc, MBBS, MSc, PhD, FAFOEM .

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Sim, M.R., Tan, S.S.H., Nixon, R.L. (2014). Malignant Neoplasms of the Skin. In: Anttila, S., Boffetta, P. (eds) Occupational Cancers. Springer, London. https://doi.org/10.1007/978-1-4471-2825-0_21

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  • DOI: https://doi.org/10.1007/978-1-4471-2825-0_21

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