Macrovascular Disease: Pathobiology of Endothelial Function, Renal Artery Remodeling, and Plaque

  • Yoshiki Matsuo
  • Amir LermanEmail author


Atherosclerotic renal vascular disease (ARVD) is the most common cause of renal artery stenosis. Endothelial dysfunction is a systemic disorder and a critical element in the pathogenesis of atherosclerotic lesions. Endothelial dysfunction leads to ARVD, and in turn, ARVD exacerbates systemic endothelial function, establishing a vicious circle. Intravascular ultrasound demonstrates that renal artery plaques have a wide variety of atherosclerotic phenotypes including vulnerable plaque features. The plaque characteristics of the renal artery are associated with the mode of arterial remodeling. With a more detailed understanding of the pathophysiology of the renal atherosclerotic plaque, the treatment strategies for atherosclerotic renal artery disease will continue to develop.


Endothelial dysfunction Renal artery plaque Remodeling Intravascular ultrasound Atherosclerosis Renal artery stenosis 


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© Springer-Verlag London 2014

Authors and Affiliations

  1. 1.Department of Cardiovascular DiseasesMayo ClinicRochesterUSA

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