Influence of Wear Particles on Local and Systemic Immune System

  • Emmanuel GibonEmail author
  • Stuart B. Goodman


Decreasing periprosthetic osteolysis due to wear particles is a current challenge and an on-going research endeavor to prolong the longevity of joint replacements. The aim of this chapter is to provide the reader keys to the understanding of how the immune system interacts with metallic and non metallic wear particles and other byproducts from joint replacements. The local and systemic immune system is involved in a complex network of chemokines, cytokines, and different cell types which in the end leads to inflammation and a foreign body reaction.


Wear debris Immune reactions Cytokines Cells 


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Copyright information

© Springer-Verlag London 2012

Authors and Affiliations

  1. 1.Department of Orthopaedic SurgeryStanford University School of MedicineStanfordUSA
  2. 2.Department of Orthopaedic SurgeryBichat Teaching Hospital, Paris School of Medicine, Paris VII UniversityParisFrance
  3. 3.Department of Orthopaedic SurgeryStanford University School of MedicineRedwood CityUSA

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