Pathogenesis of Prosthetic Joint Infections

  • Rihard TrebšeEmail author
  • Jurij Štalc


Every wound is contaminated, but not all wounds end with a ­prosthetic joint infection (PJI). The pathogenic process involves bacterial ­adhesion steps that are fundamental in the early stage of PJI development and the consecutive biofilm formation. Biofilm development is an essential step in establishment of a chronic PJI. Due to its physical and chemical proprieties, it serves as a basic structure that protects bacteria from environmental influences like host immune defenses and antibiotics. To understand the diagnostic ­principles and treatment modes, it is imperative to understand the basics of the pathogenesis of PJI.


Pathogenesis Interactions Biofilm Bacteria Host 


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© Springer-Verlag London 2012

Authors and Affiliations

  1. 1.Department for Bone infections and Adult reconstructionsOrthopaedic Hospital ValdoltraAnkaranSlovenia

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