The Corneal Disc

  • Fiona Roberts
  • Chee Koon Thum
Chapter

Abstract

Corneal transplantation is one of the most successful forms of homograft. This can be undertaken for a variety of diseases that cause corneal opacification, vascularisation, scarring and ulceration. Keratoplasty has transformed in recent years and although penetrating keratoplasty is still performed on a wide range of conditions techniques such as deep anterior lamellar keratoplasty for anterior pathology and Descemet’s membrane stripping with endothelial keratoplasty for posterior problems is now commonplace. The most common cause for keratoplasty used to be bullous keratopathy related to endothelial cell deficiency caused by anterior chamber lens implants. This has now decreased incidence and keratoconus is more common. There are also a host of infectious agents which cause keratitis including bacteria, fungi and parasites. Corneal dystrophies are uncommon but of pathological interest and can affect the anterior cornea and Bowman’s layer, the stroma and the endothelium. A significant number of specimens will result from repeat keratoplasty and the potential findings in these specimens include inflammation in relation to the host graft junction and endothelium, a retrocorneal fibrous membrane or simply loss of endothelial cells. The cornea may also be subject to mechanical trauma, burns and damage by heat and irradiation.

Keywords

Cholesterol Aspergillus Vasculitis Candida Cataract 

References

  1. 1.
    Patel NP, Kim T, Rapuano CJ, Cohen EJ, Laibson PR. Indications for and outcomes of repeat penetrating keratoplasty, 1989–1995. Ophthalmology. 2000;107:719–24.PubMedGoogle Scholar
  2. 2.
    Klintworth GK. Corneal dystrophies. Orphanet J Rare Dis. 2009;23:4–7.Google Scholar
  3. 3.
    Weiss JS, Moller HU, Lisch W, Kinoshita S, Aldave AJ, Belin MW, et al. The IC3D classification of the corneal dystrophies. Cornea. 2008;2:S1–83.Google Scholar
  4. 4.
    Poulaki V, Colby K. Genetics of anterior and stromal corneal dystrophies. Semin Ophthalmol. 2008;23:9–17.PubMedGoogle Scholar
  5. 5.
    Ramsay AS, Lee WR, Mohammed A. Changing indications for penetrating keratoplasty in the west of Scotland from 1970–1995. Eye. 1997;11:357–60.PubMedGoogle Scholar
  6. 6.
    Dobbins KR, Price FW, Whitson WE. Trends in the indications for penetrating keratoplasty in the mid-western United States. Cornea. 2000;19:813–6.PubMedGoogle Scholar
  7. 7.
    Baddon A, Jones M, Armitage J, Warwick R, Kaye S. A review of allograft ophthalmic tissue in eye surgery. Cell Tissue Bank. 2010;11:29–38.PubMedGoogle Scholar
  8. 8.
    Majo F, Rochat A, Nicolas M, Jaoudé GA, Barrandon Y. Oligopotent stem cells are distributed throughout the mammalian ocular surface. Nature. 2008;456(7219):250–4.PubMedGoogle Scholar
  9. 9.
    Dua HS, Azuara-Blanco A. Limbal stem cells of the corneal epithelium. Surv Ophthalmol. 2000;44:415–25.PubMedGoogle Scholar
  10. 10.
    Binder PS, Rock ME, Schmidt KC, Anderson JA. High-voltage electron microscopy of normal human cornea. Invest Ophthalmol Vis Sci. 1991;32:2234–43.PubMedGoogle Scholar
  11. 11.
    Marshall GA, Konstas AG, Lee WR. Immunogold localisation of extracellular matrix components in aged human cornea. I. Types I-IV collagen and laminin. Graefes Arch Clin Exp Ophthalmol. 1991;229:157–63.PubMedGoogle Scholar
  12. 12.
    Marshall GE, Konstas AG, Lee WR. Immunogold localisation of extracellular matrix components in aged human cornea. II. Collagen types V and VI. Graefes Arch Clin Exp Ophthalmol. 1991;229:164–71.PubMedGoogle Scholar
  13. 13.
    Kamai Y, Ushiki T. The three dimensional organisation of collagen fibres in the human cornea and sclera. Invest Ophthalmol Vis Sci. 1991;32:2244–58.Google Scholar
  14. 14.
    Freegard TJ. The physical basis of transparency of the normal cornea. Eye. 1997;11:465–71.PubMedGoogle Scholar
  15. 15.
    Hoppenreijs VP, Pels E, Vrensen GF, Treffers WF. Corneal endothelium and growth factors. Surv Ophthalmol. 1996;41:155–64.PubMedGoogle Scholar
  16. 16.
    Senoo T, Joyce NC. Cell cycle kinetics in corneal endothelium from old and young donors. Invest Ophthalmol Vis Sci. 2000;41:660–7.PubMedGoogle Scholar
  17. 17.
    Meek KM, Leonard DW, Connon CJ, Dennis S, Khan S. Transparency, swelling and scarring of the corneal stroma. Eye. 2003;17:927–36.PubMedGoogle Scholar
  18. 18.
    Jester JV. Corneal crystallins and the development of cellular transparency. Semin Cell Dev Biol. 2008;19:82–93.PubMedGoogle Scholar
  19. 19.
    Bourne WM, Hodge DO, McLaren JW. Estimation of corneal endothelial pump function in long-term contact lens wearers. Invest Ophthalmol Vis Sci. 1999;40:603–11.PubMedGoogle Scholar
  20. 20.
    Shimmura S, Tsubota K. Deep anterior lamellar keratoplasty. Curr Opin Ophthalmol. 2006;17:349–55.PubMedGoogle Scholar
  21. 21.
    Price MO, Price FW. Descemet’s stripping endothelial keratoplasty. Curr Opin Ophthalmol. 2007;18:290–4.PubMedGoogle Scholar
  22. 22.
    Lee JE, Oum BS, Choi HY, Lee SU, Lee JS. Evaluation of differentially expressed genes identified in keratoconus. Mol Vis. 2009;15:2480–7.PubMedGoogle Scholar
  23. 23.
    Armitage JW, Easty DL. Factors influencing the suitability of organ-cultured corneas for transplantation. Invest Ophthalmol Vis Sci. 1997;38:16–24.PubMedGoogle Scholar
  24. 24.
    Chu W. The past twenty five years in eye banking. Cornea. 2000;19:754–65.PubMedGoogle Scholar
  25. 25.
    Nishimura JK, Hodge DO, Bourne WM. Initial endothelial cell density and chronic endothelial cell loss rate in corneal transplants with late endothelial failure. Ophthalmology. 1999;106:1962–5.PubMedGoogle Scholar
  26. 26.
    Miyata K, Drake J, Osakabe Y, Hosokawa Y. Effect of donor age on morphologic variation of cultured human corneal endothelial cells. Cornea. 2001;20:59–63.PubMedGoogle Scholar
  27. 27.
    Waring GO, Rodrigues MM. Patterns of pathologic response in the cornea. Surv Ophthalmol. 1987;31:262–6.PubMedGoogle Scholar
  28. 28.
    Holbach LM, Font RL, Shivitz IA, Jones DB. Bilateral keloid-like myofibroblastic proliferations of the cornea in children. Ophthalmology. 1990;97:1188–93.PubMedGoogle Scholar
  29. 29.
    Garana RM, Petroll WM, Chen W-T, Herman IM, Barry P, Andrews P, et al. Radial keratotomy. II. Role of the myofibroblast in corneal wound contraction. Invest Ophthalmol Vis Sci. 1992;33:3271–82.PubMedGoogle Scholar
  30. 30.
    Ingraham HJ, Guber D, Green WR. Radial keratotomy. Arch Ophthalmol. 1985;103:683–8.PubMedGoogle Scholar
  31. 31.
    Yamaguchi T, Tamaki K, Kaufman HE, Katz J, Shaw EL. Histologic study of a pair of human corneas after anterior radial keratotomy. Am J Ophthalmol. 1985;100:281–92.PubMedGoogle Scholar
  32. 32.
    Marmer RH. Radial keratotomy complications. Ann Ophthalmol. 1987;19:409–11.PubMedGoogle Scholar
  33. 33.
    Glasgow BJ, Brown HN, Aizuss DH, Mondino BJ, Foos RY. Traumatic dehiscence of incisions seven years after radial keratotomy. Am J Ophthalmol. 1988;106:692–5.Google Scholar
  34. 34.
    Spirack LD, Waring GO. Excimer laser in monkeys. Arch Ophthalmol. 1991;109:15.Google Scholar
  35. 35.
    SundarRaj N, Geiss 3rd MJ, Fantes F, Hanna K, Anderson SC, Thompson KP, et al. Healing of excimer ablated monkey corneas. An immunohistochemical evaluation. Arch Ophthalmol. 1990;108:1604–10.PubMedGoogle Scholar
  36. 36.
    Hanna KD, Pouliquen YM, Waring GO, Savodelli M, Fantes F, Thompson KP. Corneal wound healing in monkeys after repeated excimer laser photorefractive keratectomy. Arch Ophthalmol. 1992;110:1286–91.PubMedGoogle Scholar
  37. 37.
    Assil KK, Quantock AJ. Wound healing in response to keratorefractive surgery. Surv Ophthalmol. 1993;38:289–302.PubMedGoogle Scholar
  38. 38.
    Binder PS, Anderson JA, Rock ME, Vrabec MP. Human excimer laser keratectomy. Clinical and histopathologic correlations. Ophthalmology. 1994;101:979–89.PubMedGoogle Scholar
  39. 39.
    McDonnell JM, Garbus JJ, McDonnell PJ. Unsuccessful excimer laser photo-therapeutic keratectomy. Clinicopathologic correlation. Arch Ophthalmol. 1992;110:977–9.PubMedGoogle Scholar
  40. 40.
    Chan W-K, Hunt KE, Glasgow BJ, Mondino BJ. Corneal scarring after photorefractive keratoplasty. Am J Ophthalmol. 1996;121:570–1.PubMedGoogle Scholar
  41. 41.
    Ivarsen A, Fiedelius W, Hjortdal JO. Three-year changes in epithelial and stromal thickness after PRK or LASIK for high myopia. Invest Ophthalmol Vis Sci. 2009;50:2061–6.PubMedGoogle Scholar
  42. 42.
    Arevalo JF. Posterior segment complications after laser-assisted in situ keratomileusis. Curr Opin Ophthalmol. 2008;19:177–84.PubMedGoogle Scholar
  43. 43.
    Read RW, Chuck RSH, Rao NA, Smith RE. Traumatic Acremonium atrogriseum keratitis following laser assisted in situ keratomileusis. Arch Ophthalmol. 2000;118:418–21.PubMedGoogle Scholar
  44. 44.
    Abrosio R, Tervo T, Wilson SE. LASIK-associated dry eye and neurotropic epitheliopathy: pathophysiology and strategies for prevention and treatment. J Refract Surg. 2008;24:396–407.Google Scholar
  45. 45.
    Knorz MC. Flap and interface complications in LASIK. Curr Opin Ophthalmol. 2002;13:242–5.PubMedGoogle Scholar
  46. 46.
    Chau GK, Dilly SA, Sheard CE, Rostron CK. Deep lamellar keratoplasty on air with lyophilised tissue. Br J Ophthalmol. 1992;76:646–50.PubMedGoogle Scholar
  47. 47.
    Pillai S, Mahmood MA. Postoperative corneal edema secondary to a free fragment of Descemet’s membrane. Arch Ophthalmol. 1991;109(1):20.PubMedGoogle Scholar
  48. 48.
    Ruiz RS, Sattci OA. Spontaneous Descemet’s membrane tear and detachment. Arch Ophthalmol. 1991;109:20–1.PubMedGoogle Scholar
  49. 49.
    Kenney MC, Chwa M. Abnormal extracellular matrix in corneas with pseudophakic bullous keratopathy. Cornea. 1990;9:115–9.PubMedGoogle Scholar
  50. 50.
    Ljubimov AV, Burgeson RE, Butkowski RJ, Couchman JR, Wu RR, Ninomiya Y, et al. Extracellular matrix alterations in human corneas with bullous keratopathy. Invest Ophthalmol Vis Sci. 1996;37:997–1007.PubMedGoogle Scholar
  51. 51.
    Heon E, Greenberg A, Kopp KK, Rootman D, Vincent AL, Billingsley G, et al. VSX1: a gene for posterior polymorphous dystrophy and keratoconus. Hum Mol Genet. 2002;11:1029–36.PubMedGoogle Scholar
  52. 52.
    Kaas-Hansen M. The histopathological changes of keratoconus. Acta Ophthalmol. 1993;71:411–4.Google Scholar
  53. 53.
    Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998;42:297–319.PubMedGoogle Scholar
  54. 54.
    Radner W, Zehetmayer M, Skorpik C, Mallinger R. Altered organization of collagen in the apex of keratoconus corneas. Ophthalmic Res. 1998;30:327–32.PubMedGoogle Scholar
  55. 55.
    Krachmer JH, Feder RS, Belin MW. Keratoconus and related non-inflammatory corneal thinning disorders. Surv Ophthalmol. 1984;28:293–322.PubMedGoogle Scholar
  56. 56.
    Pouliquen Y. Doyne lecture keratoconus. Eye (Lond). 1987;1(Pt 1):1–14.Google Scholar
  57. 57.
    Bron AJ. Keratoconus. Cornea. 1988;7(3):163–9. Review.PubMedGoogle Scholar
  58. 58.
    Zimmerman DR, Fischer RW, Winterhalter KH. Comparative studies of collagens in normal and keratoconus corneas. Exp Eye Res. 1988;46:431–42.Google Scholar
  59. 59.
    Kenney MC, Chwa M, Alba A, Saghizadeh M, Huang ZS, Brown DJ. Localization of TIMP-1, TIMP-2, TIMP-3, gelatinase A and gelatinase B in pathological human corneas. Curr Eye Res. 1998;17:238–46.PubMedGoogle Scholar
  60. 60.
    Collier SA, Madigan MC, Penfold PL. Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) and MMP-2 in normal and keratoconus corneas. Curr Eye Res. 2000;21:662–8.PubMedGoogle Scholar
  61. 61.
    Kim WJ, Rabinowitz YS, Meisler DM, Wilson SE. Keratocyte apoptosis associated with keratoconus. Exp Eye Res. 1999;69:475–81.PubMedGoogle Scholar
  62. 62.
    Brookes NH, Niederer RL, Hickey D, McGhee CN, Sherwin T. Recurrence of keratoconic pathology in penetrating keratoplasty buttons originally transplanted for keratoconus. Cornea. 2009;28:688–93.PubMedGoogle Scholar
  63. 63.
    Lim L, Pesudovs K, Coster DJ. Penetrating keratoplasty for keratoconus: visual outcome and success. Ophthalmology. 2000;107:1125–31.PubMedGoogle Scholar
  64. 64.
    Bains RA, Stern RM, Tokarewicz AC, Willis RN, Heathcote JG. Posterior stromal changes following acute corneal hydrops in keratoconus. Can J Ophthalmol. 1994;29:22–4.PubMedGoogle Scholar
  65. 65.
    Tuft SJ, Gregory WM, Buckley RJ. Acute corneal hydrops in keratoconus. Ophthalmology. 1994;101:1738–44.PubMedGoogle Scholar
  66. 66.
    Meghpara B, Nakamura H, Vemuganti GK, Murthy SI, Sugar J, Yue BY, Edward DP. Histopathologic and immunohistochemical studies in keratoglobus. Arch Ophthalmol. 2009;127:1029–35.PubMedGoogle Scholar
  67. 67.
    Liesegang TJ. Biology and molecular aspects of herpes simplex and varicella-zoster virus infections. Ophthalmology. 1992;99:781–99.PubMedGoogle Scholar
  68. 68.
    Liesegang TJ. Herpes simplex virus epidemiology and ocular importance. Cornea. 2001;20:1–13.PubMedGoogle Scholar
  69. 69.
    Holbach LM, Asano N, Naumann GO. Infection of the corneal endothelium in herpes simplex keratitis. Am J Ophthalmol. 1998;126:592–4.PubMedGoogle Scholar
  70. 70.
    Biswas S, Suresh P, Bonshek RE, Corbitt G, Tullo AB, Ridgway AE. Graft failure in human donor corneas due to transmission of herpes simplex virus. Br J Ophthalmol. 2000;84:701–5.PubMedGoogle Scholar
  71. 71.
    Leigh JF, Acharya N, Cevalios V, Margolis TP. Does asymptomatic shedding of herpes simplex virus on the ocular surface lead to false-positive diagnostic PCR results? Br J Ophthalmol. 2008;92:435–6.PubMedGoogle Scholar
  72. 72.
    Hamrah P, Pavan-Langston D, Dana R. Herpes simplex keratitis and dendritic cells at the crossroads: lessons from the past and a view into the future. Int Ophthalmol Clin. 2009;49:53–62.PubMedGoogle Scholar
  73. 73.
    Hendricks RL. An immunologist’s view of herpes simplex keratitis: Thygeson Lecture. Cornea. 1997;16:503–6.PubMedGoogle Scholar
  74. 74.
    Silva-Araujo A, Tavares AM, Lemos MM, Soares MI, Castro-Correia J, Salgado-Borges J. Primary lipid keratopathy: a morphological and biochemical assessment. Br J Ophthalmol. 1993;77:248–50.PubMedGoogle Scholar
  75. 75.
    Holbach LM, Font RL, Wilhelmus KR. Recurrent herpes simplex keratitis with concurrent epithelial and stromal involvement. Immunohistochemical and ultrastructural observations. Arch Ophthalmol. 1991;109:692–5.PubMedGoogle Scholar
  76. 76.
    Mauriello Jr JA, McLean IW, Riddle PJ. Granulomatous reaction to Bowman’s layer in herpetic keratitis and band keratopathy. Can J Ophthalmol. 1995;30:203–7.PubMedGoogle Scholar
  77. 77.
    Amano S, Oshika T, Kaji Y, Numaga J, Matsubara M, Araie M. Herpes simplex virus in the trabeculum of an eye with corneal endotheliitis. Am J Ophthalmol. 1999;127:721–2.PubMedGoogle Scholar
  78. 78.
    Riley GP, Harrall RL, Watson PG, Cawston TE, Hazleman BL. Collagenase MMP-1 and TIMP-1 in destructive corneal disease associated with rheumatoid arthritis. Eye. 1995;9:703–18.PubMedGoogle Scholar
  79. 79.
    Messmer EM, Foster CS. Vasculitic peripheral ulcerative keratitis. Surv Ophthalmol. 1999;43:379–96.PubMedGoogle Scholar
  80. 80.
    Zaher SS, Sandinha T, Roberts F, Ramaesh K. Herpes simplex keratitis misdiagnosed as rheumatoid arthritis-related peripheral ulcerative keratitis. Cornea. 2005;24:1015–7.PubMedGoogle Scholar
  81. 81.
    Guyer DR, Barraquer J, McDonnell PJ, Green WR. Terrien’s marginal degeneration: clinicopathologic case reports. Graefes Arch Clin Exp Ophthalmol. 1987;225:19–27.PubMedGoogle Scholar
  82. 82.
    Mondino BJ. Inflammatory disease of the peripheral cornea. Ophthalmology. 1988;95:463–72.PubMedGoogle Scholar
  83. 83.
    Pouliquen Y, Dhermy P, Renard G, Goichat-Nonnat L, Foster G, Salvoidelli M. Terrien’s disease: clinical and ultrastructural studies. Eye. 1989;3:791–802.PubMedGoogle Scholar
  84. 84.
    Gottsch JD, Liu SH, Minkovitz JB, Goodman DF, Srinivasan M, Stark WJ. Autoimmunity to a cornea-associated stromal antigen in patients with Mooren’s ulcer. Invest Ophthalmol Vis Sci. 1995;36:1541–7.PubMedGoogle Scholar
  85. 85.
    Acharya NR, Srinivasan M, Kundu A, Lietman TM, Whitchewr JP, Cunningham Jr ET. Mooren’s ulcer following extracapsular cataract extraction. Eur J Ophthalmol. 2008;18:351–5.PubMedGoogle Scholar
  86. 86.
    Lopez JS, Price FW, Whitcup SM, Li Q, de Smet M, Chan CC. Immunohistochemistry of Terrien’s and Mooren’s corneal degeneration. Arch Ophthalmol. 1991;109:988–92.PubMedGoogle Scholar
  87. 87.
    Diaz-Valle D, Benitez del Castillo JM, Castillo A, Sayagues O, Banares A, Garcia-Sanchez J. Immunologic and clinical evaluation of post-surgical necrotizing sclerocorneal ulceration. Cornea. 1998;17:371–5.PubMedGoogle Scholar
  88. 88.
    Williams KA, Brereton HM, Aggarwal R, Sykes PJ, Turner DR, Russ GR, et al. Use of DNA polymorphism and polymerase chain reaction to examine the survival of a human stem cell allograft. Am J Ophthalmol. 1995;120:342–50.PubMedGoogle Scholar
  89. 89.
    Erdem U, Kerimoglu H, Gundogan FC, Dagli S. Treatment of Mooren’s ulcer with topical administration of interferon alfa 2a. Ophthalmology. 2007;114:446–9.PubMedGoogle Scholar
  90. 90.
    Vail A, Gore SM, Bradley BA, Easty DL, Rogers CA, Armitage WJ. Conclusions of the corneal transplant follow up study. Collaborating Surgeons. Br J Ophthalmol. 1997;81:631–6.PubMedGoogle Scholar
  91. 91.
    Patel DV, McGhee CN. Acanthamoeba keratitis: a comprehensive photographic reference of common and uncommon signs. Clin Experiment Ophthalmol. 2009;37:232–8.PubMedGoogle Scholar
  92. 92.
    Niederkorn JY. Immune mechanisms of corneal allograft rejection. Curr Eye Res. 2007;32:1005–16.PubMedGoogle Scholar
  93. 93.
    Kuffova L, Holan V, Lumsden L, Forrester JV, Filipec M. Cell sub-populations in failed human corneal grafts. Br J Ophthalmol. 1999;83:1364–9.PubMedGoogle Scholar
  94. 94.
    Daya SM, Bell RW, Habib NE, Powell-Richards A, Dua HS. Clinical and pathologic findings in human keratolimbal allograft rejection. Cornea. 2000;19:443–50.PubMedGoogle Scholar
  95. 95.
    Gabison EE, Huet E, Baudouin C, Menashi S. Direct epithelial-stromal interaction in corneal wound healing: role of EMMPRIN/CD147 in MMPs induction and beyond. Prog Retin Eye Res. 2009;28:19–33.PubMedGoogle Scholar
  96. 96.
    Kompa S, Langefeld S, Kirchhof B, Schrage N. Corneal biopsy in keratitis performed with the microtrephine. Graefes Arch Clin Exp Ophthalmol. 1999;237:915–9.PubMedGoogle Scholar
  97. 97.
    Bullington RH, Lanier JD, Font RL. Non tuberculous mycobacterial keratitis. Arch Ophthalmol. 1992;110:519–20.PubMedGoogle Scholar
  98. 98.
    Ford JG, Huang AJW, Pflugfelder SC, Alfonso EC, Foster RK, Miller D. Nontuberculous mycobacterial keratitis in South Florida. Ophthalmology. 1998;105:1652–8.PubMedGoogle Scholar
  99. 99.
    Affra RC, Avni I, Ishibashi Y, Robin J, Kaufman H. Calcofluor and ink-potassium hydroxide preparations for identifying fungi. Am J Ophthalmol. 1985;100:719–23.Google Scholar
  100. 100.
    Sharma S, Kunimoto DY, Gopinathan U, Athmanathan S, Garg P, Rao GN. Evaluation of corneal scarping smear examination methods in the diagnosis of bacterial and fungal keratitis: a survey of eight years of laboratory experience. Cornea. 2002;21:643–7.PubMedGoogle Scholar
  101. 101.
    Kumar M, Mishra NK, Shukla PK. Sensitive and rapid polymerase chain reaction based diagnosis of mycotic keratitis through single stranded conformation polymorphism. Am J Ophthalmol. 2005;140:851–7.PubMedGoogle Scholar
  102. 102.
    Lee SH, Teng SCG. Amniotic membrane transplantation for persistent epithelial defects with ulceration. Am J Ophthalmol. 1997;123:303–12.PubMedGoogle Scholar
  103. 103.
    Chen HJ, Pires RT, Tseng SC. Amniotic membrane transplantation for severe neurotrophic corneal ulcers. Br J Ophthalmol. 2000;84:826–33.PubMedGoogle Scholar
  104. 104.
    Reiss GR, Campbell JR, Bourne WM. Infectious crystalline keratopathy. Surv Ophthalmol. 1986;31:69–72.PubMedGoogle Scholar
  105. 105.
    Christakopoulos CE, Prause JA, Heegard S. Infectious crystalline keratopathy histopathological characteristics. Acta Ophthalmol Scand. 2003;81:659–61.PubMedGoogle Scholar
  106. 106.
    Ormerod DL, Ruoff KL, Meisler DM, Wasson PJ, Kintner JC, Dunn SP, et al. Infectious crystalline keratopathy. Ophthalmology. 1991;98:159–69.PubMedGoogle Scholar
  107. 107.
    Butler TKH, Dua HS, Edwards R, Lowe JS. In vitro model of infectious crystalline keratopathy: tissue architecture determines pattern of microbial spread. Invest Ophthalmol Vis Sci. 2001;42:1243–6.PubMedGoogle Scholar
  108. 108.
    Illingworth CD, Cook SD. Acanthamoeba keratitis. Surv Ophthalmol. 1998;42:493–508.PubMedGoogle Scholar
  109. 109.
    Hammersmith KM. Diagnosis and management of Acanthamoeba keratitis. Curr Opin Ophthalmol. 2009;17:327–31.Google Scholar
  110. 110.
    Dart JK, Saw VP, Kilvington S. Acanthamoeba keratitis: diagnosis and treatment update 2009. Am J Ophthalmol. 2009;148:487–99.PubMedGoogle Scholar
  111. 111.
    Verani JR, Lorick SA, Yoder JS, Beach MJ, Braden CR, Roberts JM, Acanthamoeba keratitis investigation team, et al. National outbreak of Acanthamoeba keratitis associated with use of a contact lens solution, United States. Emerg Infect Dis. 2009;15:1236–42.PubMedGoogle Scholar
  112. 112.
    Clarke DW, Niederkorn JY. The pathophysiology of Acanthamoeba keratitis. Trends Parasitol. 2006;22:176–9.Google Scholar
  113. 113.
    Kanavi M, Javadi M, Yazdani S, Mirdehghanm S. Sensitivity and specificity of confocal scan in the diagnosis of infectious keratitis. Cornea. 2007;26:782–6.PubMedGoogle Scholar
  114. 114.
    Davis MJ, Packop KH, Epstein RJ, Grostern RJ, Cohen JA. Acanthamoeba endophthalmitis following penetrating keratoplasty for Acanthamoeba keratitis. Arch Ophthalmol. 2010;128:505–6.PubMedGoogle Scholar
  115. 115.
    Dua HS, Azuara-Blanco A, Hossain M, Lloyd J. Non-acanthameba amebic keratitis. Cornea. 1998;17:675–7.PubMedGoogle Scholar
  116. 116.
    Rumelt S, Cohen I, Rehany U. Spontaneous corneal graft ulcerative perforation due to mixed Acanthamoeba and herpes simplex eratitis: a clinicopathologic study. Cornea. 2000;19:240–2.PubMedGoogle Scholar
  117. 117.
    Font RL, Samaha AN, Keener MJ, Chevez-Barrios P, Goosey JD. Corneal microsporidiosis. Report of case, including electron microscopic observations. Ophthalmology. 2000;107:1769–75.PubMedGoogle Scholar
  118. 118.
    Rauz S, Tuft S, Dart JK, Bonshek R, Luthert P, Curry A. Ultrastructural examination of two cases of stromal microsporidial keratitis. J Med Microbiol. 2004;53:775–81.PubMedGoogle Scholar
  119. 119.
    Kennedy SM, Shankland GS, Lee WR, Sekundo W. Keratitis due to the fungus Acremonium (Cephalosporium). Eye. 1994;8:692–4.PubMedGoogle Scholar
  120. 120.
    Alfonso JF, Baamonde MB, Santos MJ, Astudillo A, Fernandez-Vega L. Acremonium fungal infection in 4 patients after laser in situ keratomileusis. J Cataract Refract Surg. 2004;30:262–7.PubMedGoogle Scholar
  121. 121.
    Sridhar MS, Gopinthan U, Garg P, Sharma S, Rao GN. Ocular nocardia infections with special emphasis on the cornea. Surv Ophthalmol. 2001;45:361–78.PubMedGoogle Scholar
  122. 122.
    Rhem MN, Wilhelmus KR, Font RL. Infectious crystalline keratopathy caused by Candida parapsilosis. Cornea. 1996;15:543–5.PubMedGoogle Scholar
  123. 123.
    Kumar M, Arova R, Sanga L, Sota DS. Black corneal ulcer. Cornea. 1997;16:590–1.PubMedGoogle Scholar
  124. 124.
    Ritterband DC, Shah M, Seedor JA. Colletrichium graminocola: a new corneal pathogen. Cornea. 1997;16:362–4.PubMedGoogle Scholar
  125. 125.
    Wagoner MD, Badr IA, Hidayat AA. Chrysosporium parvum keratomycosis. Cornea. 1999;18:616–20.PubMedGoogle Scholar
  126. 126.
    Alexandrakis G, Palma LA, Miller D, Alfonso EC. Capnocytophagia keratitis. Ophthalmology. 2000;107:1503–6.PubMedGoogle Scholar
  127. 127.
    Bullock JD. An outbreak of fusarium keratitis associated with contact lens use in the northeastern United States. Cornea. 2008;27:973–4.PubMedGoogle Scholar
  128. 128.
    Malecha MA. Fungal keratitis caused by scopulariopsis brevicaulis treated successfully with natamycin. Cornea. 2004;23:201–3.PubMedGoogle Scholar
  129. 129.
    Browning DJ, Proia AD. Ocular rosacea. Surv Ophthalmol. 1986;31:145–58.PubMedGoogle Scholar
  130. 130.
    Cameron JA. Shield ulcers and plaques of the cornea in vernal keratoconjunctivitis. Ophthalmology. 1995;102:985–93.PubMedGoogle Scholar
  131. 131.
    Aitken DA, Beirouty ZA, Lee WR. Ultrastructural study of the corneal epithelium in the recurrent erosion syndrome. Br J Ophthalmol. 1995;79:282–9.PubMedGoogle Scholar
  132. 132.
    Garrana RM, Zieske JD, Assouline M, Gipson IK. Matrix metalloproteinases in epithelia from human recurrent corneal erosion. Invest Ophthalmol Vis Sci. 1999;40:1266–70.PubMedGoogle Scholar
  133. 133.
    Ramamurthi S, Rahman MQ, Dutton GN, Ramaesh K. Pathogenesis, clinical features and management of recurrent corneal erosions. Eye. 2006;20:635–44.PubMedGoogle Scholar
  134. 134.
    Szentmary N, Seitz B, Langebucher A, Schlotzer-Schrehardt U, Hofmann-Rummelt C, Naumann GO. Histologic and ultrastructural changes in corneas with granular and macular dystrophy after excimer laser phototherapeutic keratectomy. Cornea. 2006;25:257–63.PubMedGoogle Scholar
  135. 135.
    Charles NC, Young JA, Kumar A, Grossniklaus HE, Palay DA, Bowers J, Green WR. Band-shaped and whorled microcystic dystrophy of the corneal epithelium. Ophthalmology. 2000;107:1761–4.PubMedGoogle Scholar
  136. 136.
    Lisch W, ButtenerA OF, Boddeker Im Engel H, Lisch C, Ziegler A, Grzeschik K. Lisch corneal dystrophy is genetically distinct from Meesmann corneal dystrophy and maps to Xp22.3. Am J Ophthalmol. 2000;130:461–8.PubMedGoogle Scholar
  137. 137.
    Small KW, Mullen L, Barletta J, Graham K, Glasgow B, Stern G, et al. Mapping of Reis-Bücklers’ corneal dystrophy to chromosome 5q. Am J Ophthalmol. 1996;121:384–90.PubMedGoogle Scholar
  138. 138.
    Lohse E, Stock EL, Jones JCR, Braude LS, O’Grady RB, Roth SI. Reis-Buckler’s corneal dystrophy. Immunofluorescent and electron microscopic studies. Cornea. 1989;8:200–9.PubMedGoogle Scholar
  139. 139.
    Kuchle MWR, Green WR, Volcker HE, Barraquer J. Re evaluation of corneal dystrophies of Bowman’s layer and the anterior stroma (Reis-Buckler’s and Thiel-Benke types): a light and electron microscopic study of eight corneas and a review of the literature. Cornea. 1995;14:333–54.PubMedGoogle Scholar
  140. 140.
    Streeten BW, Qi Y, Klintworth GK, Eagle RC, Bennett K. Immunolocalization of beta ig-h3 protein in 5q31-linked corneal dystrophies and normal corneas. Arch Ophthalmol. 1999;117:67–75.PubMedGoogle Scholar
  141. 141.
    Gear HC, Ramaesh K, Roberts F. Recurrence of Thiel-Behnke corneal dystrophy: an electron microscopic study. Br J Ophthalmol. 2005;89:518.PubMedGoogle Scholar
  142. 142.
    Santo RM, Yamaguchi T, Kanai A, Okisaka S, Nakajima A. Clinical and histopathological features of corneal dystrophies in Japan. Ophthalmology. 1995;102:557–67.PubMedGoogle Scholar
  143. 143.
    Konishi M, Yamada M, Nakamura Y, Mashima Y. Varied appearance of cornea of patients with corneal dystrophy associated with R124H mutation in the BIGH3 gene. Cornea. 1999;18:424–9.PubMedGoogle Scholar
  144. 144.
    Kocak-Altintas AG, Kocak-Midillioglu I, Akarsu AN, Duman S. BIGH3 gene analysis in the differential diagnosis of corneal dystrophies. Cornea. 2001;20:64–8.PubMedGoogle Scholar
  145. 145.
    Matta CS, Tabbara KF, Cameron JA, Hidayat AA, al-Rajhi AA. Climatic droplet keratopathy with corneal amyloidosis. Ophthalmology. 1991;98:192–5.PubMedGoogle Scholar
  146. 146.
    Suesskind D, Auw-Haedrich C, Schorderet DF, Munier FL, Loeffler KU. Keratoepithelium in secondary corneal amyloidosis. Graefes Arch Clin Exp Ophthalmol. 2006;244:725–31.PubMedGoogle Scholar
  147. 147.
    Lyons CJ, McCartney AC, Kirkness CM, Ficker LA, Steele AD, Rice NS. Granular corneal dystrophy. Visual results and pattern of recurrence after lamellar or penetrating keratoplasty. Ophthalmology. 1994;101:1812–7.PubMedGoogle Scholar
  148. 148.
    Akhtar S, Meek KM, Ridgway AE, Bonshek RE, Bron AJ. Deposits and proteoglycan changes in primary and recurrent granular dystrophy of the cornea. Arch Ophthalmol. 1999;117:310–21.PubMedGoogle Scholar
  149. 149.
    Holland EJ, Daya SM, Stone EM, Folberg R, Dobler AA, Cameron JD, et al. Avellino corneal dystrophy. Clinical manifestations and natural history. Ophthalmology. 1992;99:1564–8.PubMedGoogle Scholar
  150. 150.
    Lucarelli MJ, Adamis AP. Avellino corneal dystrophy. Arch Ophthalmol. 1994;112:418–9.PubMedGoogle Scholar
  151. 151.
    Folberg R, Stone EM, Sheffield VC, Mathers WD. The relationship between granular, lattice type I, and Avellino corneal dystrophies. A histopathologic study. Arch Ophthalmol. 1994;112:1080–5.PubMedGoogle Scholar
  152. 152.
    Edward DP, Thonar EJ, Srinivasan M, Yue BJ, Tso MO. Macular dystrophy of the cornea. A systemic disorder of keratan sulfate metabolism. Ophthalmology. 1990;97:1194–200.PubMedGoogle Scholar
  153. 153.
    Klintworth GK, Reed J, Stainer GA, Binder PS. Recurrence of macular corneal dystrophy within grafts. Am J Ophthalmol. 1983;95:60–72.PubMedGoogle Scholar
  154. 154.
    Akova YA, Kirkness CM, McCartney AC, Ficker LA, Rice NSC, Steele AD, Mc G. Recurrent macular corneal dystrophy following penetrating keratoplasty. Eye. 1990;4:698–705.PubMedGoogle Scholar
  155. 155.
    Iwamoto M, Nawa Y, Maumenee IH, Young-Ramsaran J, Matalon R, Green WR. Ocular histopathology and ultrastructure of Morquio syndrome (systemic mucopolysaccharidosis IV A). Graefes Arch Clin Exp Ophthalmol. 1990;228:342–9.PubMedGoogle Scholar
  156. 156.
    Waring GO, Malaty A, Grossniklaus H, Kaj H. Climatic proteoglycan stromal keratopathy(a new corneal degeneration). Am J Ophthalmol. 1995;120:330–41.PubMedGoogle Scholar
  157. 157.
    Weiss JS, Rodrigues MM, Kruth HS, Rajagopalan S, Rader DJ, Kachadoorian H. Panstromal Schynder’s corneal dystrophy. Ultrastructural and histochemical studies. Ophthalmology. 1992;99:1072–81.PubMedGoogle Scholar
  158. 158.
    Weiss JS. Schnyder crystalline dystrophy sine crystals. Recommendation for a revision of nomenclature. Ophthalmology. 1996;103:465–73.PubMedGoogle Scholar
  159. 159.
    Winder AF, Alexander R, Garner A, Johnston D, Vallance D, McCreanor G, et al. The pathology of Tangier disease (familial high density lipoprotein deficiency). J Clin Pathol. 1996;49:407–10.PubMedGoogle Scholar
  160. 160.
    Hidayat AA, Margo CE, Mauriello JA, North I. Lipofuscinosis of the cornea. A clinicopathologic study of three cases. Ophthalmology. 1992;99:1796–804.PubMedGoogle Scholar
  161. 161.
    Barchiesi BJ, Eckel RH, Ellis PP. The cornea and disorders of lipid metabolism. Surv Ophthalmol. 1991;36:1–22.PubMedGoogle Scholar
  162. 162.
    Koster H, Savoldelli M, Dumon MF, Du Bourg L, Clerc M, Pouliquen Y. A fish-eye-like familial condition with massive corneal clouding and dyslipoproteinaemia. Cornea. 1992;11:452–64.PubMedGoogle Scholar
  163. 163.
    Winder AF, Owen JS, Pritchard PH, Lloyd-Jones D, Vallance DT, White P, et al. A first British case of fish-eye disease presenting at age 75 years: double heterozygote for defined and new mutations affecting LCAT structure and expression. J Clin Pathol. 1999;52:228–30.PubMedGoogle Scholar
  164. 164.
    Adamis AP, Filatov V, Tripathi BJ, Tripathi RC. Fuchs endothelial dystrophy of the cornea. Surv Ophthalmol. 1993;38:149–68.PubMedGoogle Scholar
  165. 165.
    Borderie VM, Baudrimont M, Vallee A, Ereau TL, Gray F, Laroche L. Corneal endothelial cell apoptosis in patients with Fuchs’ dystrophy. Invest Ophthalmol Vis Sci. 2000;41:2501–5.PubMedGoogle Scholar
  166. 166.
    Olsen T, Ehlers N, Favini E. Long term results of corneal grafting in Fuchs’ endothelial dystrophy. Acta Ophthalmol (Copenh). 1984;62:445–52.Google Scholar
  167. 167.
    Mullaney PB, Risco JM, Teichmann K, Millar L. Congenital hereditary endothelial dystrophy associated with glaucoma. Ophthalmology. 1995;102:186–92.PubMedGoogle Scholar
  168. 168.
    Laganowski HC, Sherrard ES, Kerr Muir MG, Buckley RJ. Distinguishing features of the iridocorneal endothelial syndrome and posterior polymorphous dystrophy: value of specular microscopy. Br J Ophthalmol. 1991;75:212–6.PubMedGoogle Scholar
  169. 169.
    Callaghan M, Hand CK, Kennedy SM. Homozygosity mapping and linkage analysis demonstrate that autosomal recessive congenital hereditary endothelial dystrophy (CHED) and autosomal dominant CHED are genetically distinct. Br J Ophthalmol. 1999;83:115–9.PubMedGoogle Scholar
  170. 170.
    Toma NM, Ebenezer ND, Inglehearn CF, Plant C, Ficker LA, Bhattacharya SS. Linkage of congenital hereditary endothelial dystrophy to chromosome 20. Hum Mol Genet. 1995;4:2395–8.PubMedGoogle Scholar
  171. 171.
    Vithana EN, Morgan PE, Sundaresan P, Ebenezer ND, Tan DT, Mohamed MD, et al. Mutations in sodium-borate cotransporter SLC4A11 cause recessive congenital hereditary endothelial dystrophy (CHED2). Nat Genet. 2006;38:755–7.PubMedGoogle Scholar
  172. 172.
    McCartney ACE, Kirkness CM. Comparison between posterior polymorphous dystrophy and congenital hereditary endothelial dystrophy of the cornea. Eye. 1988;2:63–70.PubMedGoogle Scholar
  173. 173.
    Sekundo W, Marshall GE, Lee WR, Kirkness CM. Immunoelectron labelling of matrix components in congenital hereditary endothelial dystrophy. Graefes Arch Clin Exp Ophthalmol. 1994;232:337–46.PubMedGoogle Scholar
  174. 174.
    Sekundo WS, Lee WR, Kirkness CM, Aitken DA, Fleck B. An ultrastructural investigation of an early manifestation of the posterior polymorphous dystrophy of the cornea. Ophthalmology. 1994;101:1422–31.PubMedGoogle Scholar
  175. 175.
    Levy SG, Moss J, Noble BA, McCartney ACE. Early-onset posterior polymorphous dystrophy. Arch Ophthalmol. 1996;114:1265–8.PubMedGoogle Scholar
  176. 176.
    Jirsova K, Merjava S, Martincova R, Gwilliam R, Ebenezer N, Liskova P, Filipec M. Immunohistochemical characterization of cytokeratins in the abnormal corneal endothelium of posterior polymorphous corneal dystrophy patients. Exp Eye Res. 2007;84:680–6.PubMedGoogle Scholar
  177. 177.
    Molia LM, Lanier JD, Font RL. Posterior polymorphous dystrophy associated with posterior amyloid degeneration of the cornea. Am J Ophthalmol. 1999;127:86–8.PubMedGoogle Scholar
  178. 178.
    Boruchoff SA, Weiner MJ, Albert DM. Recurrence of posterior polymorphous corneal dystrophy after penetrating keratoplasty. Am J Ophthalmol. 1990;109:323–8.PubMedGoogle Scholar
  179. 179.
    Sekundo WS, Lee WR, Aitken DA, Kirkness CM. Multirecurrence of corneal posterior polymorphous dystrophy: an ultrastructural study. Cornea. 1994;13:509–15.PubMedGoogle Scholar
  180. 180.
    Schmid E, Lisch W, Philipp W, Lechner S, Gottinger W, Schlotzer-Schrehardt U, et al. A new, X-linked endothelial corneal dystrophy. Am J Ophthalmol. 2006;141:478–87.PubMedGoogle Scholar
  181. 181.
    Lee WR, Marshall GE, Kirkness CM. Corneal endothelial cell abnormalities in an early stage of the iridocorneal endothelial syndrome. Br J Ophthalmol. 1994;78:624–31.PubMedGoogle Scholar
  182. 182.
    Hemady RK, Patel A, Blum S, Nirankari VS. Bilateral iridocorneal endothelial syndrome: case report and review of the literature. Cornea. 1994;13:368–72.PubMedGoogle Scholar
  183. 183.
    Alvarado JG, Murphy CG, Maglio M, Hetherington J. Pathogenesis of Chandler’s syndrome, essential iris atrophy and the Cogan-Reese syndrome. 1 Alterations of the corneal endothelium. Invest Ophthalmol Vis Sci. 1986;27:853–72.PubMedGoogle Scholar
  184. 184.
    Hirst LW, Bancroft J, Yamauchi K, Green WR. Immunohistochemical pathology of the corneal endothelium in the iridocorneal endothelial syndrome. Invest Ophthalmol Vis Sci. 1995;36:820–7.PubMedGoogle Scholar
  185. 185.
    Sharif KW, Casey TA, Casey R, Hoe WK. Penetrating keratoplasty for bilateral acute corneal calcification. Cornea. 1992;11:155–62.PubMedGoogle Scholar
  186. 186.
    Schlötzer-Schrehardt U, Zagorski Z, Holbach LM, Hofmann-Rummelt C, Naumann GO. Corneal stromal calcification after topical steroid-phosphate therapy. Arch Ophthalmol. 1999;117:1414–8.PubMedGoogle Scholar
  187. 187.
    Kaiser PK, Pireda R, Albert DM, Shore JW. “Black cornea” after long-term epinephrine use. Arch Ophthalmol. 1992;110:1273–5.PubMedGoogle Scholar
  188. 188.
    Sekundo W, Seifert P, Seitz B, Loeffler KU. Long term ultrastructural changes in human corneas after tattooing with non metallic substances. Br J Ophthalmol. 1999;83:219–24.PubMedGoogle Scholar
  189. 189.
    Lang GK, Green WR, Maumenee AE. Clinicopathologic studies of keratoplasty eyes obtained post mortem. Am J Ophthalmol. 1986;101:28–40.PubMedGoogle Scholar
  190. 190.
    Loeffler KU. Iris melanocytes on the posterior corneal surface in congenital glaucoma. Cornea. 1991;10:70–4.Google Scholar
  191. 191.
    Garner A, Kirkness CM. Corneal gammopathy. Cornea. 1988;7(1):44–9.PubMedGoogle Scholar
  192. 192.
    Bourne WM, Kyle RA, Brubaker RF, Griepp PR. Incidence of the corneal crystals in the monoclonal gammopathies. Am J Ophthalmol. 1989;107:192–3.PubMedGoogle Scholar
  193. 193.
    Steuhl K-P, Knorr M, Rohrbach JM, Lisch W, Kaisering E, Thiel HJ. Paraproteinaemic corneal deposits in plasma cell myeloma. Am J Ophthalmol. 1994;111:312–8.Google Scholar
  194. 194.
    Sekundo W, Seifert P. Monoclonal corneal gammopathy: topographic considerations. Ger J Ophthalmol. 1996;5:262–7.PubMedGoogle Scholar
  195. 195.
    Schelonka LP, Ogawa GSH, O’Brien TP, Green WR. Acute unilateral immunoprotein deposition in IgM monoclonal gammopathy. Arch Ophthalmol. 2000;118:125–6.PubMedGoogle Scholar
  196. 196.
    Menegay M, Lee D, Tabbara KF, Cafaro TA, Urrets-Zavalia JA, Serra HM, Bhattacharya SK. Proteomic analysis of climatic keratopathy droplets. Invest Ophthalmol Vis Sci. 2008;49:2829–37.PubMedGoogle Scholar
  197. 197.
    Kaji Y, Nagai R, Amano S, Takazawa Y, Fukayama M, Oshika T. Advanced glycation end product deposits in climatic droplet keratopathy. Br J Ophthalmol. 2007;91:85–8.PubMedGoogle Scholar
  198. 198.
    Norman BC, Oliver J, Cheeks L, Hull DS, Birnbaum D, Green K. Corneal endothelial permeability after anterior chamber silicone oil. Ophthalmology. 1990;97:1671–7.PubMedGoogle Scholar
  199. 199.
    Foulks GN, Hatchell DL, Proia AD, Klintworth GK. Histopathology of silicone oil keratopathy in humans. Cornea. 1991;10:29–37.PubMedGoogle Scholar
  200. 200.
    Wagoner MD. Chemical injuries of the eye: current concepts in pathophysiology and therapy. Surv Ophthalmol. 1997;41:275–313.PubMedGoogle Scholar
  201. 201.
    Yang LL, Lambert SR, Lynn MJ, Stulting RD. Long term results of corneal graft survival in infants and children with Peters anomaly. Ophthalmology. 1999;106:833–48.PubMedGoogle Scholar
  202. 202.
    Hansen LH, Prause JU, Ehlers N, Hegaard S. Primary corneal myxoma. Acta Ophthalmol Scand. 2004;82:224–7.PubMedGoogle Scholar
  203. 203.
    Sehu KW, Lee WR, editors. Ophthalmic pathology: an illustrated guide for clinicians. Malden: Blackwell Publishing Ltd; 2008. ISBN 9780727917799.Google Scholar

Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  • Fiona Roberts
    • 1
  • Chee Koon Thum
    • 2
  1. 1.Southern General HospitalGlasgowUK
  2. 2.Western General HospitalEdinburghUK

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