Abstract
The pancreatic intraepithelial neoplasia (PanIN) nomenclature and classification system, used to describe the microscopic epithelial precursor lesions of pancreatic ductal adenocarcinoma, replaced at least 70 different diagnostic terms for the same entities. The average time taken for the genetic progression from an initiating mutation in a normal ductal epithelial cell, through the PanINs, to invasive ductal adenocarcinoma has recently been estimated to be 11.7 years. This chapter discusses the classification and microscopic features of PanIN, together with the differential diagnosis, including intraductal papillary mucinous neoplasia and cancerization of ducts.
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Campbell, F., Verbeke, C.S. (2013). Pancreatic Intraepithelial Neoplasia. In: Pathology of the Pancreas. Springer, London. https://doi.org/10.1007/978-1-4471-2449-8_8
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DOI: https://doi.org/10.1007/978-1-4471-2449-8_8
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