Abstract
There are six types of serous cystic neoplasm, all of which are included in this chapter. The macroscopic and microscopic features of microcystic and macrocystic serous cystadenomas are discussed in detail. The features of solid serous adenoma, von Hippel-Lindau-associated serous cystic neoplasm, mixed serous-neuroendocrine neoplasm, and serous cystadenocarcinoma are also included, together with those of the recently described “serous cystadenoma with subtotal cystic degeneration.” A detailed section on differential diagnosis discusses the morphology and immunohistochemical profiles of the different diagnostic entities.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bosman FT, Carneiro F, Hruban RH, Theise ND. WHO classification of tumours of the digestive system. Lyon: IARC; 2010. p. 280, chapter 12.
Khashab MA, Shin EJ, Amateau S, Canto MI, Hruban RH, Fishman EK, et al. Tumor size and location correlate with behavior of pancreatic serous cystic neoplasms. Am J Gastroenterol. 2011;106:1521–6.
Hashimoto M, Watanabe G, Miura Y, Matsuda M, Takeuchi K, Mori M. Macrocystic type of serous cystadenoma with a communication between the cyst and pancreatic duct. J Gastroenterol Hepatol. 2001;16:836–8.
Tripodi SA, Civitelli S, Schurfeld K, Cintorino M. Microcystic adenoma of the pancreas (glycogen-rich cystadenoma) with stromal amyloid deposits. Histopathology. 2000;37:147–9.
Perez-Ordonez B, Naseem A, Lieberman PH, Klimstra DS. Solid serous adenoma of the pancreas. The solid variant of serous cystadenoma? Am J Surg Pathol. 1996;20:1401–5.
Panarelli NC, Park KJ, Hruban RH, Klimstra DS. Microcystic serous cystadenoma of the pancreas with subtotal cystic degeneration: another neoplastic mimic of pancreatic pseudocyst. Am J Surg Pathol. 2012;36:726–31.
Blandamura S, Parenti A, Famengo B, Canesso A, Moschino P, Pasquali C, et al. Three cases of pancreatic serous cystadenoma and endocrine tumour. J Clin Pathol. 2007;60:278–82.
Strobel O, Z’graggen K, Schmitz-Winnenthal FH, Friess H, Kappeler A, Zimmermann A, et al. Risk of malignancy in serous cystic neoplasms of the pancreas. Digestion. 2003;68:24–33.
Malleo G, Bassi C, Rossini R, Manfredi R, Butturini G, Massignani M, et al. Growth pattern of serous cystic neoplasms of the pancreas: observational study with long-term magnetic resonance surveillance and recommendations for treatment. Gut. 2012;61:746–51.
Del Chiaro M, Verbeke C, Salvia R, Klöppel G, Werner J, McKay C, Friess H, Manfredi R, van Cutsem E, Löhr M, Segersvard R and the European Study Group on Cystic Tumours of the Pancreas. European experts consensus statement on cystic tumours of the pancreas. Dig Liv Dis. 2013 [Epub ahead of print].
Further Reading
Hruban RH, Pitman MB, Klimstra DS. Tumors of the pancreas, Atlas of tumor pathology, 4th series, Fascicle 6. Washington, D.C.: Armed Forces Institute of Pathology; 2007. p. 33–50, chapter 4.
Terris B, Fukushima N, Hruban RH. Serous neoplasms of the pancreas. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. WHO classification of tumours of the digestive system. Lyon: IARC; 2010. p. 296–9, chapter 12.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag London
About this chapter
Cite this chapter
Campbell, F., Verbeke, C.S. (2013). Serous Cystic Neoplasia. In: Pathology of the Pancreas. Springer, London. https://doi.org/10.1007/978-1-4471-2449-8_15
Download citation
DOI: https://doi.org/10.1007/978-1-4471-2449-8_15
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-4471-2448-1
Online ISBN: 978-1-4471-2449-8
eBook Packages: MedicineMedicine (R0)