• P. N. Patsalos


Felbamate (Fig. 1) corresponds chemically to 2-phenyl-1,3-propanediol dicarbamate with an empirical formula of C11H14N2O4 and a molecular weight of 238.24.


Valproic Acid Antiepileptic Drug Therapeutic Drug Monitoring Renal Excretion Plasma Protein Binding 
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  1. 1. 
    Wagner ML, Graves NM, Marienau K, Holmes GB, Remmel RP, Leppik IE. Discontinuation of phenytoin and carbamazepine in patients receiving felbamate. Epilepsia. 1991;32:398–406PubMedCrossRefGoogle Scholar
  2. 2. 
    Glue P, Banfield CR, Perhach JL, Mather GG, Racha JK, Levy RH. Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation. Clin Pharmacokinet. 1997;33:214–24.PubMedCrossRefGoogle Scholar
  3. 3. 
    Hussein G, Troupin AS, Montouris G. Gabapentin interaction with felbamate. Neurology. 1996;47:1106.PubMedCrossRefGoogle Scholar
  4. 4. 
    Colucci R, Glue P, Holt B, Babfield C, Reidenberg P, Meechan JW, Pai S, Nomeir A, Lim J, Lin CC, Affrime MB. Effect of felbamate on the pharmacokinetics of lamotrigine. J Clin Pharmacol. 1996;36:634–8.PubMedCrossRefGoogle Scholar
  5. 5. 
    Hulsman JARJ, Rentmeester TW, Banfield CR, Reidenberg P, Colucci RD, Meehan JW, Radwanski E, Mojavarian P, Lin CC, Nezamis J, Affrime MB, Glue P. Effects of felbamate on the pharmacokinetics of the monohydroxy and dihydroxy metabolites of oxcarbazepine. Clin Pharmacol Ther. 1995;58:383–9.PubMedCrossRefGoogle Scholar
  6. 6. 
    Kelley MT, Walson PD, Cox S, Dusci LJ. Population pharmacokinetics of felbamate in children. Ther Drug Monit. 1997;19:29–36.CrossRefGoogle Scholar
  7. 7. 
    Wagner ML, Graves NM, Leppik IE, Remmel RP, Shmaker RC, Ward D, Perhach JL. The effect of felbamate on valproic acid disposition. Clin Pharmacol Ther. 1994;56:494–502.PubMedCrossRefGoogle Scholar
  8. 8. 
    Reidenberg P, Glue P, Banfield C, Colucci R, Meehan J, Rey E, Radwanski E, Nomeir A, Lim J, Lin C, Guillaume M, Affrime MB. Pharmacokinetic interaction studies between felbamate and vigabatrin. Br J Clin Pharmacol. 1995;40:157–60.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  • P. N. Patsalos
    • 1
    • 2
  1. 1.UCL-Institute of Neurology Department of Clinical and Experimental EpilepsyLondonLondon
  2. 2.Epilepsy Society Chalfont Centre for EpilepsyBuckinghamshireUK

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