• P. N. Patsalos


Clonazepam (Fig. 1) corresponds chemically to 5-(2-chlorophenol)-1,3-dihydro-7-nitro-2H-1,4 benzodiazepin-2-one with an empirical formula of C15H10ClN3O3 and a molecular weight of 315.71.


Valproic Acid Empirical Formula Therapeutic Drug Monitoring Plasma Protein Binding Pharmacokinetic Interaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Lai AA, Levy RH, Cutler RE. Time-course of interaction between carbamazepine and clonazepam in normal man. Clin Pharmacol Ther. 1978;24:316–23.PubMedGoogle Scholar
  2. 2.
    Colucci R, Glue P, Banfield C, Reidenberg P, Meehan J, Radwanski E, Korduba C, Lin C, Dogterom P, Ebels T, Hendriks G, Jonkman JHG, Affrime M. Effect of felbamate on the pharmacokinetics of clonazepam. Am J Ther. 1996;3:294–7.PubMedCrossRefGoogle Scholar
  3. 3.
    Halasz P, Kalviainen R, Mazurkiewicz-Beldzinska M, Rosenow F, Doty P, Hebert D, Sullivan T. Adjunctive lacosamide for partial-onset seizures: efficacy and safety results from a randomized controlled trial. Epilepsia. 2009;50:443–53.PubMedCrossRefGoogle Scholar
  4. 4.
    Eriksson AS, Hoppu K, Nergardh A, Boreu L. Pharmacokinetic interactions between lamotrigine and other antiepileptic drugs in children with intractable epilepsy. Epilepsia. 1996;37:769–73.PubMedCrossRefGoogle Scholar
  5. 5.
    Perucca E, Baltes E, Ledent E. Levetiracetam: absence of pharmacokinetic interactions with other antiepileptic drugs (AEDs). Epilepsia. 2000;41(Suppl):150.Google Scholar
  6. 6.
    Khoo KC, Mendels J, Rothbart M, Garland WA, Colburn WA, Min BH, Lucek R, Carbone JJ, Boxenbaum HG, Kaplan SA. Influence of phenytoin and phenobarbital on the disposition of a single oral dose of clonazepam. Clin Pharmacol Ther. 1980;28:368–75.PubMedCrossRefGoogle Scholar
  7. 7.
    Nanda RN, Johnson RH, Keogh HJ, Lambie DG, Melville ID. Treatment of epilepsy with clonazepam and its effect on other anticonvulsants. J Neurol Neurosurg Psychiatry. 1977; 40:538–43.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  • P. N. Patsalos
    • 1
    • 2
  1. 1.UCL-Institute of Neurology Department of Clinical and Experimental EpilepsyLondonLondon
  2. 2.Epilepsy Society Chalfont Centre for EpilepsyBuckinghamshireUK

Personalised recommendations