Soft Tissue and Bone and Joint Cytology
Cytology is often used as a first stage in the diagnosis of any superficial mass, although core biopsy or excision biopsy may be more appropriate depending on the clinical scenario. Aspiration cytology is straight forward in most cases, and it can be extremely useful for the initial assessment of a range of soft tissue tumors. Although cytology is mainly used for the diagnosis of soft tissue tumors in specialist centers, it is appropriate for any general cytologist to have a reasonable knowledge of the typical findings of any soft tissue lesion as these can be found in deep locations, often within organs, and their nature is not immediately apparent to the aspirator. This chapter outlines the diagnostic features of the cytological appearance of soft tissue and bone tumors, and it also describes the microscopic appearance that helps diagnose a range of joint diseases.
KeywordsSoft Tissue Tumor Malignant Peripheral Nerve Sheath Tumor Soft Tissue Lesion Granular Cell Tumor Epithelioid Sarcoma
Useful Resources and Suggested Reading
- Costa MJ, Campman SC, Davis RL, Howell LP. Fine-needle aspiration cytology of sarcoma: retrospective review of diagnostic utility and specificity. Diagn Cytopathol. 2002;15:1–4.Google Scholar
- Fletcher CDM, Unni KK, Mertens F. Pathology and genetics of tumours of soft tissue and bone (WHO blue book). Lyon: IARC Press; 2002.Google Scholar
- Tissue pathways for bone and soft tissue specimens. London: The Royal College of Pathologists 2011. www.rcpath.org/publications-media/publications/datasets.
- Weiss S, Goldblum J, Folpe AL, editors. Enzinger and Weiss’s soft tissue pathology. 5th ed. Philadelphia: Mosby; 2008.Google Scholar