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Preparing the Endometrium to Maximize Success: The Dynamics of Artificial Cycles

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Principles of Oocyte and Embryo Donation

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Abstract

In vitro fertilization (IVF) was developed for women with diseased or absent Fallopian tubes. Rapidly however, the clinical successes witnessed in IVF opened in their wake the doors to the until-then uncharted realm of oocyte exchanges. Together with its variant for male factor infertility – intracytoplasmic sperm injection (ICSI) – IVF is now called the assisted reproductive technology (ART). Logically, therefore, we refer to oocyte donation – with either IVF or ICSI – as donor-egg ART (DE-ART).

Using donated oocytes for women whose ovaries have failed – in DE-ART – implied however that endometrial receptivity may be attained through the prescribed use of exogenous hormones. At the outset, at a time when results of general IVF were relatively meager, the need to rely solely on artificially prepared endometrium in recipients tarnished any prospect that DE-ART would be successful. Hence, the improbable and rapid unraveling that placed the results of DE-ART not only at par but most often above those of the corresponding regular ART programs was certainly a surprise

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Authors and Affiliations

  1. Division Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Université Paris Descartes – Hôpital Cochin, 53 Ave de l’Observatoire, Paris, 75014, France

    Dominique de Ziegler M.D.

  2. Department of Obstetrics and Gynecology, Université Paris Descartes – Hôpital Cochin, 53 Ave de l’Observatoire, Paris, 75014, France

    Isabelle Streuli M.D., Anne Marszalek M.D., Vanessa Gayet M.D. & Charles Chapron M.D.

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  1. Dominique de Ziegler M.D.
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  2. Isabelle Streuli M.D.
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  3. Anne Marszalek M.D.
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  4. Vanessa Gayet M.D.
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  5. Charles Chapron M.D.
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Correspondence to Dominique de Ziegler M.D. .

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  1. , Center for Women’s Reproductive Care, Columbia University, 1790 Broadway, New York, 10019, New York, USA

    Mark V. Sauer

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de Ziegler, D., Streuli, I., Marszalek, A., Gayet, V., Chapron, C. (2013). Preparing the Endometrium to Maximize Success: The Dynamics of Artificial Cycles. In: Sauer, M. (eds) Principles of Oocyte and Embryo Donation. Springer, London. https://doi.org/10.1007/978-1-4471-2392-7_9

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