Clinical Presentation in Diffuse Low-Grade Gliomas
Diffuse low-grade gliomas (DLGG) are primary brain tumors that typically arise in adults. Seizures are the most common presenting symptom. Management decisions are determined by tumor size, location, imaging characteristics, and histopathological findings. Most DLGG ultimately progress to high-grade lesions, and the events leading to this transition are the subject of active investigation. MRI is the standard imaging modality for assessing the progression of these tumors. New advances in imaging technologies now allow for multimodal evaluation of their phenotype based on metabolism and improved prediction regarding anaplastic transformation. A typical case is presented along with discussion of commonly encountered neurological syndromes. Conventional imaging technologies as well as new areas are discussed briefly.
KeywordsSeizures Perfusion imaging Disconnection syndrome Spectroscopy Positron emission
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