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Surgery for Primary Hyperparathyroidism

  • R. James England
  • Hisham Mehanna
Chapter

Abstract

Primary hyperparathyroidism (PHPT) is the third most common endocrine disorder affecting 0.3 % of the population and up to 1–3 % of postmenopausal women (Jessica et al. 2011).

PHPT is diagnosed by a raised serum (corrected) calcium associated with an inappropriately unsuppressed PTH level. It arises from oversecretion of PTH due to parathyroid gland(s) overactivity.

Primary HPT may be treated conservatively or surgically. Only approximately one-tenth of diagnosed patients end up undergoing parathyroidectomy.

Inherited forms of HPT: Germline mutations leading to loss of heterozygosity in tumor suppressor genes in multiple endocrine neoplasia (MEN)1 and CDC73, combined with a second mutation in somatic cells, can lead to parathyroid tumor development (Jessica et al. 2011).

Keywords

Parathyroid Gland Primary Hyperparathyroidism Parathyroid Adenoma Thyroid Lobe Minimally Invasive Parathyroidectomy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Bilezikian JP, Khan AA, Potts Jr JT, Third International Workshop on the Management of Asymptomatic Primary Hyperthyroidism. Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the third international workshop. J Clin Endocrinol Metabol. 2009;94(2):335–9.CrossRefGoogle Scholar
  2. Jessica MK-F, Sandra S, Donald A, Jibran S, Aneal K. Primary hyperparathyroidism: an overview. Int J Endocrinol. 2011;2011:251410.Google Scholar
  3. Schaapveld M, Jorna FH, Aben KK, Haak HR, Plukker JT, Links TP. Incidence and prognosis of parathyroid gland carcinoma: a population-based study in the Netherlands estimating the preoperative diagnosis. Am J Surg. 2011;202(5):509–7.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  1. 1.Department of ENT/Head and Neck SurgeryHull and East Yorkshire Hospitals NHS Trust, Castle Hill HospitalEast Riding of YorkshireUK
  2. 2.Department of Head and Neck Surgery, School of Cancer Sciences, Institute of Head and Neck Studies and EducationUniversity of BirminghamBirminghamUK

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