Management of Conn’s Syndrome

  • Vasilis A. Constantinides
  • Fausto PalazzoEmail author


Aldosterone is the major mineralocorticoid steroid hormone. It is synthesized from cholesterol and secreted from the zona glomerulosa of the adrenal cortex


Atrial Natriuretic Peptide Primary Aldosteronism Adrenal Vein Adrenal Adenoma Zona Glomerulosa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Further Reading

  1. Burton TJ, Mackenzie IS, Balan K, et al. Evaluation of the sensitivity and specificity of 11C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn’s adenomas. J Clin Endocrinol Metab. 2012;97(1):100–9.PubMedCrossRefGoogle Scholar
  2. Conn JW. Presidential address. I. Painting background. II. Primary aldosteronism, a new clinical syndrome. J Lab Clin Med. 1955;45(1):3–17.PubMedGoogle Scholar
  3. Gallay BJ, Ahmad S, Xu L, et al. Screening for primary aldosteronism without discontinuing hypertensive medications: plasma aldosterone-renin ratio. Am J Kidney Dis. 2001;37(4):699–705.PubMedCrossRefGoogle Scholar
  4. Giacchetti G, Ronconi V, Lucarelli G, et al. Analysis of screening and confirmatory tests in the diagnosis of primary aldosteronism: need for a standardized protocol. J Hypertens. 2006;24(4):737–45.PubMedCrossRefGoogle Scholar
  5. Mattsson C, Young Jr WF. Primary aldosteronism: diagnostic and treatment strategies. Nat Clin Pract Nephrol. 2006;2(4):198–208; quiz, 1 p following 30.PubMedCrossRefGoogle Scholar
  6. Milliez P, Girerd X, Plouin PF, et al. Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism. J Am Coll Cardiol. 2005;45(8):1243–8.PubMedCrossRefGoogle Scholar
  7. Montori VM, Young Jr WF. Use of plasma aldosterone concentration-to-plasma renin activity ratio as a screening test for primary aldosteronism. A systematic review of the literature. Endocrinol Metab Clin North Am. 2002;31(3):619–32, xi.PubMedCrossRefGoogle Scholar
  8. Rossi GP, Bernini G, Caliumi C, et al. A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients. J Am Coll Cardiol. 2006;48(11):2293–300.PubMedCrossRefGoogle Scholar
  9. Schwartz GL, Turner ST. Screening for primary aldosteronism in essential hypertension: diagnostic accuracy of the ratio of plasma aldosterone concentration to plasma renin activity. Clin Chem. 2005;51(2):386–94.PubMedCrossRefGoogle Scholar
  10. Young WF, Stanson AW, Thompson GB, et al. Role for adrenal venous sampling in primary aldosteronism. Surgery. 2004;136(6):1227–35.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  1. 1.Department of Thyroid and Endocrine SurgeryImperial College NHS TrustLondonUK

Personalised recommendations