Anaplastic Thyroid Cancer



Anaplastic, or undifferentiated, thyroid cancer is one of the most aggressive solid tumors with an extremely poor prognosis. It is believed that around 50 % of anaplastic thyroid cancers arise from a prior or coexistent differentiated thyroid carcinoma. The loss of the tumor suppressor gene p53 is an important step in this process.


Thyroid Cancer Thyroid Carcinoma Clinical Target Volume Local Control Rate Medullary Thyroid Cancer 
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Further Reading

  1. Ain KB, Egorin MJ, DeSimone PA. Treatment of anaplastic thyroid carcinoma with paclitaxel: phase 2 trial using ninety-six-hour infusion. Collaborative Anaplastic Thyroid Cancer Health Intervention Trials (CATCHIT) Group. Thyroid. 2000;10(7):587–94.PubMedCrossRefGoogle Scholar
  2. Bhatia A, Rao A, Ang KK, et al. Anaplastic thyroid cancer: clinical outcomes with conformal radiotherapy. Head Neck. 2010;32(7):829–36.PubMedGoogle Scholar
  3. Haigh PI, Ituarte PH, Wu HS, et al. Completely resected anaplastic thyroid carcinoma combined with adjuvant chemotherapy and irradiation is associated with prolonged survival. Cancer. 2001;91(12):2335–42.PubMedCrossRefGoogle Scholar
  4. Lim SM, Shin SJ, Chung WY, et al. Treatment outcome of patients with anaplastic thyroid cancer: a single center experience. Yonsei Med J. 2012;53(2):352–7.PubMedCrossRefGoogle Scholar
  5. Mooney CJ, Nagaiah G, Fu P, et al. A phase II trial of fosbretabulin in advanced anaplastic thyroid carcinoma and correlation of baseline serum-soluble intracellular adhesion molecule-1 with outcome. Thyroid. 2009;19(3):233–40.PubMedCrossRefGoogle Scholar
  6. Nagaiah G, Hossain A, Mooney CJ, et al. Thyroid cancer: a review of epidemiology pathogenesis, and treatment. J Oncol. 2011;2011:542358.PubMedCrossRefGoogle Scholar
  7. Patel KN, Shaha AR. Poorly differentiated and anaplastic thyroid cancer. Cancer Control. 2006;13(2):119–28.PubMedGoogle Scholar
  8. Tennvall J, Lundell G, Wahlberg P, et al. Anaplastic thyroid carcinoma: three protocols combining doxorubicin, hyperfractionated radiotherapy and surgery. Br J Cancer. 2002;86:1848–53.PubMedCrossRefGoogle Scholar
  9. ZYBRESTAT(TM) (CA4P) improves overall survival in a phase 2/3 trial (FACT Study) of patients with Anaplastic Thyroid Cancer (ATC). OXiGENE press release of Phase 2/3 results Sept 2010 posted at

Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  1. 1.Department of OncologyQueen Elizabeth Hospital Cancer CentreBirmingham, West MidlandsUK

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