The job of the cerebral vascular system is to deliver sufficient fuel and metabolites to meet the metabolic needs of all parts of the brain. Clearly, lack of blood flow - ischemia - is the underlying mechanism of brain infarctions: infarction accounts for 80% of all strokes. The metabolic needs of different brain regions vary, and demand also depends on the level of metabolic activity of a given area. Roy and Sherrington (1890) (Friedland and Iadecola 1991) first studied the ability of the vascular system to change local regional blood flow in response to changes in neuronal activity. More recently, PET scan studies have confirmed that increased activity and glucose metabolism in a local region is usually accompanied by increased regional blood flow to that region.
KeywordsSugar Ischemia Lism
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