Stroke investigators have made great progress in defining the neurochemical consequences of brain ischemia, as well as providing a scientific foundation for the medical and surgical therapies of secondary stroke prevention. Nevertheless, it is striking that relatively little is known of the initiating process of the clinical event constituting stroke. This process, lacking precise characterization, is typically referred to as ’hypoperfusion’ or ’embolization’. Current neurodiagnostic technology has blurred, rather than clarified, this distinction. An example of this phenomenon comes from the landmark North American Symptomatic Carotid Endarterectomy Trial, in which the efficacy of surgical removal of symptomatic carotid plaques appeared to be directly related to the degree of hemodynamic compromise produced by these lesions (NASCET Collaborators 1991). Yet angiography performed in the first hours after stroke commonly shows possible embolic occlusion distal to carotid stenosis (del Zoppo et al. 1992).
KeywordsTissue Factor Carotid Stenosis Tissue Factor Expression Stroke Risk Factor Tissue Factor mRNA
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- Ameriso SF, Sager P, Fisher M (1992) Atrial fibrillation, congestive heart failure, and the middle cerebral artery: an ultrasound analysis. J Neuroimag 2: 190–194Google Scholar
- Benveniste EN (1992) Inflammatory cytokines within the central nervous system: sources, function, and mechanisms of action. Am J Physiol 263 (Cell Physiol) 32: C1–C16Google Scholar
- Eddleston M, de la Torre JC, Oldstone MBA, Loskutoff DJ,Edgington TS, Mackman N (1993) Astrocytes are the primary source of tissue factor in the murine central nervous system. J Clin Invest 92: 349–358Google Scholar
- Love PE, Santoro SA (1990) Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus ( SLE) and in non-SLE disorders. Ann Intern Med 112: 682–698Google Scholar
- Sandset PM, Warn-Cramer BJ, Maki SL, Rapaport SI (1992) Immunodepletion of extrinsic pathway inhibitor sensitizes rabbits to endotoxin-induced intravascular coagulation and the generalized Shwartzman reaction. Blood 78: 1496–1502Google Scholar