Abstract
At the beginning of the study of the changes produced by the acquired immune deficiency syndrome (AIDS) in the nervous system, all complications were thought to be due exclusively to opportunistic infections. Indeed, the early paper by Snider et al (1983) conveyed this impression by describing known organisms as the cause of almost all abnormalities. Also the ‘subacute encephalitis’, characterized by ‘subtle cognitive changes accompanied by malaise, lethargy...’, was found to be an opportunistic infection as intranuclear inclusions of cytomegalovirus were found within some of the microglial nodules. A relationship between viral infection and lymphomas, already found in patients undergoing organ transplants (Hanto et al, 1981), was confirmed in AIDS patients, all of whom have positive serology for the Epstein—Barr virus (EBV) (Fauci et al, 1984). The role of EBV was subsequently confirmed by Shaerer et al (1985), who documented the evolution of an EBV-stimulated polyclonal to a monoclonal B-cell proliferation and eventually to monoclonal B-cell lymphoma.
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Scaravilli, F., Gray, F., Mikol, J., Sinclair, E. (1993). Pathology of the Nervous System. In: Scaravilli, F. (eds) The Neuropathology of HIV Infection. Springer, London. https://doi.org/10.1007/978-1-4471-1957-9_6
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