HIV Infection: A Cellular Approach

  • J. N. Weber

Abstract

The human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2) are RNA viruses which belong to the lentivirus group of the retrovirus family (Weiss, 1985). In common with other members of this group which infect animals (visna/maedi virus, equine infectious anaemia virus, caprine arthritis/encephalitis virus), HIV is a non-transforming virus (that is, not directly oncogenic) which replicates through the generation of a proviral DNA intermediate by the action of the retroviral enzyme RNA-directed DNA polymerase (reverse transcriptase, RT). HIV is a virus capable of causing lysis in infected cells. There is a visible cytopathic effect in vitro, which can be used for assays of HIV infectivity. In vivo, a persistent infection is established following integration of proviral DNA into the host genome. Infection lasts for the life of the cell, and after sufficient cells are infected, infection lasts for the life of the host. All retroviral infections appear to be persistent.

Keywords

Permeability Hepatitis Lymphoma Leukemia Dementia 

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Copyright information

© Springer-Verlag London Limited 1993

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  • J. N. Weber

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