Abstract
The definition of secondary tumor is that it has a different histologic diagnosis from the first one. It has been known for a long time that both benign and malignant secondary neoplasms can occur in patients who have been treated successfully for a primary tumor. As the number of survivors of primary neoplasms increases, so does the incidence of malignancy later in life. A child cured of a malignant tumour has about a 10% chance of developing a second malignant neoplasm in the next 20 years. The development of secondary tumor is favoured by radiotherapy, genetic susceptibility and chemotherapy.
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Literature
Constine LS. Late effects of radiation therapy. Pediatrician 1991; 18: 37–48
Forte V, Shimotakahara S, Crysdale WS, Thorner P. Recurring giant-cell granuloma at the site of previous radiation therapy. J Otolaryngol 1990; 19: 285–7
Freeman C, Gledhill R, Chevalier LM, Whitehead VM, Esseltine DL. Osteogenic sarcoma following treatment with megavoltage radiation and chemotherapy for bone tumours in children. Med Pediatr Oncol 1980; 8: 375–82
Gutjahr P. EEG Befunde bei ALL Patienten 10 Jahre nach Bestrahlungund Cytostatikatherapie. Klin Ped 1990; 202: 153–6
Li FP. Second malignant tumours after cancer in childhood. Cancer 1977; 40: 1899–902
Meadows AT, D’Angio GJ, Mike V, et al. Patterns of second malignant neoplasms in children. Cancer 1977; 40: 1903–11
Meadows AT, Strong LC, Li FP, et al. Bone sarcoma as a second malignant neoplasm in children: influence of radiation and genetic predisposition. Cancer 1980; 46: 2603–6
Mike V, Meadows AT, D’Angio GJ. Incidence of second malignant neoplasms in children: results of an international study. Lancet 1982; 2: 1326–31
Mulvihill JJ, McKeen EA. Discussion: genetics of multiple primary tumors. A clinical etiologic approach illustrated by three patients. Cancer 1977; 40: 1867–71
Oberlin O, Bernard A, Flamant O, et al. Les secondes tumeurs malignes de l’enfant. Etude de 38 cas. Arch Fr Pediatr 1984; 41: 241–8
Penn I. Second malignant neoplasms associated with immunosupressive medications. Cancer 1976; 37: 1024–32
Pons A, Arlet J, Alibellis MJ. La dégénerescence maligne de la dysplasie fibreuse des os. Revue générale à propos de deux observations. Ann Radiol 1974; 17: 713–20
Smith J. Postradiation sarcoma of bone in Hodgkin’s disease. Skeletal Radiol 1987; 16: 524–32
Toorkey BC, Unni KK, Dahlin DC. Case report 714. Skeletal Radiol 1992; 21: 121–3
Tountas AA, Fornasier VL, Hardwood AR, Leung PMK. Postirradiation sarcoma of bone. A perspective. Cancer 1979; 43: 182–7
Tsuruta T, Ogihara Y. Malignant tumours arising in patients with congenital bone disease. Investigation by a questionnaire. Tap J Hum Genet 1984; 29: 31–7
Vanel D, Coffre C, Zemoura L, Oberlin O. Chondrosarcoma in children subsequent to other malignant tumours in different localtions. Skeletal Radiol 1984; 11: 96–101
Vanel D, Hagay C, Rebibo G, Oberlin O, Masselot J. Study of three radio-induced malignant fibrohistiocytomas of bone. Skeletal Radiol 1983; 9: 174–8
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© 1993 Springer-Verlag London Limited
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Adler, CP., Kozlowski, K. (1993). Secondary Malignant Neoplasms. In: Primary Bone Tumors and Tumorous Conditions in Children. Springer, London. https://doi.org/10.1007/978-1-4471-1951-7_37
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DOI: https://doi.org/10.1007/978-1-4471-1951-7_37
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