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International Yearbook of Nephrology 1993 pp 45–52Cite as

Light-Chain Deposition Disease: Diagnosis, Prognosis and Therapy

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Abstract

Light-chain deposition disease (LCDD) is a systemic disease characterized by monotypic light-chain (LC) deposits. Although various organs may be affected, it is usually heralded by renal involvement. Diagnosis is made on immunohistologic findings: deposits are reactive with one anti-light-chain antiserum (kappa or lambda) and lack amyloid characteristics. LCDD is always associated with B-cell dyscrasias, but in one third of reported cases the lymphoplasmacytic proliferation does not fit the usual criteria for malignancy. In this article we review the prominent pathological and clinical features that are currently important to consider in the clinical care of patients with LCDD.

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Author information

Authors and Affiliations

  1. Département de Néphrologie, Hôpital Necker, 149, rue de Sèvres, 75015, Paris, France

    Dominique Chauveau & Dominique Ganeval

Authors
  1. Dominique Chauveau
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  2. Dominique Ganeval
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Editor information

Editors and Affiliations

  1. Department of Nephrology, University of Naples, Naples, Italy

    Vittorio E. Andreucci

  2. Middlesex School of Medicine, The Rayne Institute, University College, London, UK

    Leon G. Fine

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© 1992 Springer-Verlag London Limited

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Chauveau, D., Ganeval, D. (1992). Light-Chain Deposition Disease: Diagnosis, Prognosis and Therapy. In: Andreucci, V.E., Fine, L.G. (eds) International Yearbook of Nephrology 1993. Springer, London. https://doi.org/10.1007/978-1-4471-1948-7_3

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  • DOI: https://doi.org/10.1007/978-1-4471-1948-7_3

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1950-0

  • Online ISBN: 978-1-4471-1948-7

  • eBook Packages: Springer Book Archive

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