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Therapeutic Antibodies to Microorganisms

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Therapeutic Antibodies

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Abstract

Immunoglobulin preparations against microorganisms are used currently for the prevention and treatment of a wide variety of infections. Initially, intramuscular immunoglobulin (IM IgG) preparations were given, but there has been renewed interest following the development of intravenous immunoglobulin (IVIG) preparations (Yap 1992). The use of antibody preparations for the prevention and treatment of various infectious diseases has a long history (Table 8.1), dating back to 1891, when sheep serum was used by Von Behring and Kitasato for the successful treatment of diphtheria in a child (Behring 1893). This work had followed the experimental use of equine antitoxin raised against diphtheria toxin and was a landmark in the history of antibody therapy because it was the first time that passive immunization had ever been performed successfully in humans.

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  1. P. L. Yap
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Editors and Affiliations

  1. Department of Chemical Pathology, St Bartholomew’s Hospital Medical College, Charterhouse Square, London, EC1M 7BQ, UK

    John Landon MD, FRCP

  2. Joint Academic Unit of Obstetrics, Gynaecology and Reproductive Physiology, St Bartholomew’s Hospital Medical College, West Smithfield, London, EC1A 7BE, UK

    Tim Chard MD, FRCOG

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© 1995 Springer-Verlag London Limited

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Yap, P.L. (1995). Therapeutic Antibodies to Microorganisms. In: Landon, J., Chard, T. (eds) Therapeutic Antibodies. Springer, London. https://doi.org/10.1007/978-1-4471-1937-1_8

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  • DOI: https://doi.org/10.1007/978-1-4471-1937-1_8

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