The Molecular Biology of Apolipoprotein B
An elevated level of circulating cholesterol is a most important risk factor for atherosclerosis. Cholesterol is carried in the plasma as low-density lipoprotein (LDL). LDL is an oily droplet, containing a core of hydrophobic cholesteryl esters and a surface monolayer of phospholipid and free cholesterol at the surface. The particle is stabilized and made soluble in the water of the blood by the presence at its surface of a huge protein apolipoprotein (apo) B (Scott 1989a).
KeywordsLipoprotein Particle Primer Extension Analysis Basic Peptide Thrombin Cleavage Site Lipoprotein Assembly
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- Higuchi K, Hospattankar AV, Law SW, Meglin N, Cortright J, Brewer HB Jr (1988) Human apolipoprotein B (apoB) mRNA: identification of two distinct apoB mRNAs, an mRNA with the apoB-100 sequence and an apoB mRNA containing a premature in-frame translational stop codon, in both liver and intestine. Proc Natl Acad Sci USA 85:1772–1776PubMedCrossRefGoogle Scholar