Description and Principles of Neuroactivation
Recent advances in our knowledge of the local patterns of brain functional activity began with the studies of Lassen (Lassen et al. 1978) who developed techniques to measure blood flow in circumscribed regions of the intact human brain with the aid of radioactive isotopes. Even in the early studies, which required carotid artery cannulation and which had poor resolution by modern standards, Lassen and his colleagues demonstrated specific repeatable patterns of cortical blood flow associated with particular states and tasks. More recently the development of positron emission tomography (PET) and single-photon emission tomography (SPET) has further revolutionized our ability to view the living, working human brain.
KeywordsPositron Emission Tomography Cerebral Blood Flow Regional Cerebral Blood Flow Activation Task Cereb Blood Flow
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- Costa DC, Ell PJ, Cullum ID, et al (1986) The in vivo distribution of 99Tcm-HMPAO in normal man. Nuclear Med Comm 7:647–658Google Scholar
- Luria AR (1980) Higher cortical functions in man, 2nd edn. Basic Books, New YorkGoogle Scholar
- Mazziotta JC, Phelps ME (1986) Positron emission tomography studies of the brain. In: Phelps M, Mazziotta J, Schelbert H (eds) Positron emission tomography and autoradiography: principles and applications for the brain and heart. Raven Press, New York, pp 493–579Google Scholar
- Risberg J (1987) Development of high-resolution two-dimensional measurement of regional cerebral blood flow. In: Wade J, Knezevic S, Maximilian VA, Mubrin Z, Prohvnic I (eds) Impact of functional imaging in neurology and psychiatry. Libbey, London, pp 35–43Google Scholar
- Risberg J (1989) Regional cerebral blood flow measurements with high temporal and spatial resolution. In: Ottson D, Rostene W (eds) Visualization of brain functions. Wenner-Gren International Symposium Series, vol 53. Macmillan Press, London, pp 153–158Google Scholar
- Roland PE, Friberg L (1985) Localization of cortical areas activated by thinking. J Neurophysiol 53:1219–1243Google Scholar
- Stuss DT, Benson DF (1986) The frontal lobes. Raven Press, New YorkGoogle Scholar
- Talairach J, Szilka G (1967) Atlas of stereotaxic anatomy of the telencephalon. Masson & Cie, ParisGoogle Scholar