Description and Principles of Neuroactivation

  • Mark S. George
  • Howard A. Ring
  • Durval C. Costa
  • Peter J. Ell
  • Kypros Kouris
  • Peter H. Jarritt


Recent advances in our knowledge of the local patterns of brain functional activity began with the studies of Lassen (Lassen et al. 1978) who developed techniques to measure blood flow in circumscribed regions of the intact human brain with the aid of radioactive isotopes. Even in the early studies, which required carotid artery cannulation and which had poor resolution by modern standards, Lassen and his colleagues demonstrated specific repeatable patterns of cortical blood flow associated with particular states and tasks. More recently the development of positron emission tomography (PET) and single-photon emission tomography (SPET) has further revolutionized our ability to view the living, working human brain.


Positron Emission Tomography Cerebral Blood Flow Regional Cerebral Blood Flow Activation Task Cereb Blood Flow 
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  1. Andersen AR, Friberg HH, Schmidt JF, et al (1988) Quantitative measurements of cerebral blood flow using SPECT and 99mTc-D,L-HMPAO compared to xenon-133. J Cereb Blood Flow Metab 8:S69–S81PubMedCrossRefGoogle Scholar
  2. Andreasen NC (1988) Evaluation of brain imaging techniques in mental illness. Annual Rev Med 39:335–345CrossRefGoogle Scholar
  3. Batjer HH, Devous MD, Meyer MJ, et al (1988) Cerebrovascular haemodynamics in arteriovenous malformation complicated by normal perfusion pressure breakthrough. Neurosurgery 22:503– 509PubMedCrossRefGoogle Scholar
  4. Battisstin L, Pizzolato G, Dam M, et al (1989) Single-photon emission computed tomography studies with 99m-Tc-hexamethylpropyleneamine oxime in dementia: effects of acute administration of L-acetylcarnitine. Eur Neurol 29:261–265CrossRefGoogle Scholar
  5. Biersack HJ, Linke D, Brassel F, et al (1987) Technetium-99m HMPAO brain SPECT in epileptic patients before and during unilateral hemispheric anesthesia (Wada test): report of three cases. J Nucl Med 28:1763–1767PubMedGoogle Scholar
  6. Chollet F, Celsis P, Clanet M, et al (1989) SPECT study of cerebral blood flow reactivity after acetazolamide in patients with transient ischaemic attacks. Stroke 20:458–464PubMedCrossRefGoogle Scholar
  7. Costa DC, Ell PJ, Cullum ID, et al (1986) The in vivo distribution of 99Tcm-HMPAO in normal man. Nuclear Med Comm 7:647–658Google Scholar
  8. Dahl A, Russel D, Nyberg-Hansen R, et al (1989) Effect of nitroglycerin on cerebral circulation measured by transcranial Doppler and SPECT. Stroke 20:1733–1736PubMedCrossRefGoogle Scholar
  9. Delecluse F, Voordecker P, Raftopoulos C (1989) Vertebrobasilar insufficiency revealed by xenon-133 inhalation SPECT. Stroke 20:952–956PubMedCrossRefGoogle Scholar
  10. Ginsberg MD, Yoshii F, Vibulsresth S, et al (1987) Human task-specific somatosensory activation. Neurology 37:1301–1308PubMedGoogle Scholar
  11. Goldenberg G, Podreka I, Steiner M, et al (1987) Patterns of regional cerebral blood flow related to memorizing of high and low imagery words — an emission computer tomography study. Neuropsychologia 25:473–485PubMedCrossRefGoogle Scholar
  12. Goldenberg G, Podreka I, Uhl F, et al (1989) Cerebral correlates of imagining colours, faces and a map. I. SPECT of regional cerebral blood flow. Neuropsychologia 27:1315–1328PubMedCrossRefGoogle Scholar
  13. Lammertsma AA, Frackowiak RSJ, Hoffman JM, et al (1989) The C1502 build-up technique to measure regional cerebral blood-flow and volume of distribution of water. J Cereb Blood Flow Metab 9:461–470PubMedCrossRefGoogle Scholar
  14. Lang W, Lang M, Podreka I, et al (1988) DC-potential shifts and regional cerebral blood flow reveal frontal cortex involvement in human visuomotor learning. Exp Brain Res 71:353–364PubMedGoogle Scholar
  15. Lassen NA, Ingvar DH, Skinhoj E (1978) Brain function and blood flow. Sci Am 239:62–71PubMedCrossRefGoogle Scholar
  16. Lassen NA, Andersen AR, Friberg L, et al (1988) The retention of [99mTc]-D,L-HMPAO in the human brain after intracarotid bolus injection: a kinetic analysis. J Cereb Blood Flow Metab 8 [Suppl 1]:S13–S22PubMedCrossRefGoogle Scholar
  17. Luria AR (1980) Higher cortical functions in man, 2nd edn. Basic Books, New YorkGoogle Scholar
  18. Matsuda H, Higashi S, Asli IN, et al (1988) Evaluation of cerebral collateral circulation by technetium-99m HMPAO brain SPECT during Matas test: report of three cases. J Nucl Med 29:1724–1729PubMedGoogle Scholar
  19. Mazziotta JC, Phelps ME (1984) Human sensory stimulation and deprivation: positron emission tomographic results and strategies. Ann Neurol 15:S50–S60PubMedCrossRefGoogle Scholar
  20. Mazziotta JC, Phelps ME (1986) Positron emission tomography studies of the brain. In: Phelps M, Mazziotta J, Schelbert H (eds) Positron emission tomography and autoradiography: principles and applications for the brain and heart. Raven Press, New York, pp 493–579Google Scholar
  21. Petersen SE, Fox PT, Posner MI, et al (1988) Positron emission tomographic studies of the cortical anatomy of single-word processing. Nature 331:585–589PubMedCrossRefGoogle Scholar
  22. Risberg J (1987) Development of high-resolution two-dimensional measurement of regional cerebral blood flow. In: Wade J, Knezevic S, Maximilian VA, Mubrin Z, Prohvnic I (eds) Impact of functional imaging in neurology and psychiatry. Libbey, London, pp 35–43Google Scholar
  23. Risberg J (1989) Regional cerebral blood flow measurements with high temporal and spatial resolution. In: Ottson D, Rostene W (eds) Visualization of brain functions. Wenner-Gren International Symposium Series, vol 53. Macmillan Press, London, pp 153–158Google Scholar
  24. Roland PE, Friberg L (1985) Localization of cortical areas activated by thinking. J Neurophysiol 53:1219–1243Google Scholar
  25. Sharp PF, Smith FW, Gemmell HG, et al (1986) Technetium-99m-HMPAO stereoisomers as potential agents for imaging regional cerebral blood flow. J Nucl Med 27:171–177PubMedGoogle Scholar
  26. Stuss DT, Benson DF (1986) The frontal lobes. Raven Press, New YorkGoogle Scholar
  27. Talairach J, Szilka G (1967) Atlas of stereotaxic anatomy of the telencephalon. Masson & Cie, ParisGoogle Scholar
  28. Walker-Batson D, Wendt JS, Devous MD, et al (1988) A long-term follow-up case study of crossed aphasia assessed by single-photon emission tomography (SPECT), language, and neuropsychological testing. Brain Lang 33:311–322PubMedCrossRefGoogle Scholar
  29. Weinberger DR, Berman KF, Zee RF (1986) Physiologic dysfunction of prefrontal cortex in schizophrenia: I. Regional cerebral blood flow evidence. Arch Gen Psychiatry 43:114–124PubMedGoogle Scholar
  30. Woods SW, Hegeman IM, Zubal IG, et al (1991) Visual stimulation increases technetium-99m-HMPAO distribution in human visual cortex. J Nucl Med 32:210–215PubMedGoogle Scholar

Copyright information

© Springer-Verlag London Limited 1991

Authors and Affiliations

  • Mark S. George
    • 1
    • 2
  • Howard A. Ring
    • 3
  • Durval C. Costa
    • 4
  • Peter J. Ell
    • 5
  • Kypros Kouris
    • 6
    • 7
  • Peter H. Jarritt
    • 8
  1. 1.Raymond Way Neuropsychiatry Research Group, Department of Clinical NeurologyInstitute of NeurologyLondonEngland
  2. 2.Department of Psychiatry and Behavioral SciencesMedical University of South CarolinaCharlestonUSA
  3. 3.Raymond Way Neuropsychiatry Research Group, Department of Clinical NeurologyInstitute of NeurologyLondonEngland
  4. 4.Institute of Nuclear MedicineUniversity College and Middlesex School of Medicine (UCMSM)LondonEngland
  5. 5.Institute of Nuclear MedicineUniversity College and Middlesex School of Medicine (UCMSM)LondonEngland
  6. 6.Institute of Nuclear MedicineUniversity College and Middlesex School of Medicine (UCMSM)LondonEngland
  7. 7.University of KuwaitKuwait CityKuwait
  8. 8.Institute of Nuclear MedicineUniversity College and Middlesex School of Medicine (UCMSM)LondonEngland

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