Activation Studies in Specific Disease States: Future Applications

  • Mark S. George
  • Howard A. Ring
  • Durval C. Costa
  • Peter J. Ell
  • Kypros Kouris
  • Peter H. Jarritt


In Chap. 9 we reviewed the exciting potential of SPET neuroactivation for understanding how the brain works in healthy controls. Despite this potential for studying normal brain function, SPET may possibly lag behind PET in this area over the next decade for several reasons. First, it is usually easier to label biologically active compounds with a radioactive carbon, nitrogen, fluoride or oxygen atom than it is to label them with single photon emitters such as 99mTc or 123I. Additionally, the shorter physical half-life of the tracers used in PET allow multiple images (6–10) to be taken of the same subject in a single activation session, thus increasing the statistical power to detect subtle functional changes. Of course, these are countered by the expense and relative non-availability of PET as we saw in Chaps. 1 and 2.


Regional Cerebral Blood Flow Transient Ischaemic Attack Activation Protocol Specific Disease State Radioactive Carbon 
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Copyright information

© Springer-Verlag London Limited 1991

Authors and Affiliations

  • Mark S. George
    • 1
    • 2
  • Howard A. Ring
    • 3
  • Durval C. Costa
    • 4
  • Peter J. Ell
    • 5
  • Kypros Kouris
    • 6
    • 7
  • Peter H. Jarritt
    • 8
  1. 1.Raymond Way Neuropsychiatry Research Group, Department of Clinical NeurologyInstitute of NeurologyLondonEngland
  2. 2.Department of Psychiatry and Behavioral SciencesMedical University of South CarolinaCharlestonUSA
  3. 3.Raymond Way Neuropsychiatry Research Group, Department of Clinical NeurologyInstitute of NeurologyLondonEngland
  4. 4.Institute of Nuclear MedicineUniversity College and Middlesex School of Medicine (UCMSM)LondonEngland
  5. 5.Institute of Nuclear MedicineUniversity College and Middlesex School of Medicine (UCMSM)LondonEngland
  6. 6.Institute of Nuclear MedicineUniversity College and Middlesex School of Medicine (UCMSM)LondonEngland
  7. 7.University of KuwaitKuwait CityKuwait
  8. 8.Institute of Nuclear MedicineUniversity College and Middlesex School of Medicine (UCMSM)LondonEngland

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