Factors Affecting Clinical Progression and Mortality
Although much has been published on the surgical treatment of leg ischaemia, relatively little is known about claudication in general and the fate of the majority of patients with chronic leg ischaemia who never present to a specialist (usually surgical) department. In a review of the literature on the fate of the claudicant (Dormandy et al. 1989), it was concluded that on the scanty evidence available the prevalence of intermittent claudication in men below the age of 50 is approximately 1% to 1.5%, rising rapidly with age to over 5% in older men. In the few reports where men and women were studied at an early stage of the disease, their ratio was less than 2:1. However, in most studies looking at a more advanced stage, the ratio of men to women is much higher, ranging from 3:1 to 13:1. This would suggest that the prognosis of the local disease in women is much better than in men, a view supported by the recent PACK (Prevention of Atherosclerotic Complications by Ketanserin) analysis (Dormandy and Murray 1991).
KeywordsPlacebo Cholesterol Catheter Europe Smoke
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